[1]陈永华,谢健龙,吴 琴,等.DNA损伤反应和极光激酶家族在肿瘤发生与发展中的作用及关系研究进展[J].陕西医学杂志,2024,(11):1576-1579.[doi:DOI:10.3969/j.issn.1000-7377.2024.11.030]
　CHEN Yonghua,XIE Jianlong,WU Qin,et al.Research progress on the role and relationship between DNA damage response and aurora kinase family in tumorigenesis and development[J].,2024,(11):1576-1579.[doi:DOI:10.3969/j.issn.1000-7377.2024.11.030]
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DNA损伤反应和极光激酶家族在肿瘤发生与发展中的作用及关系研究进展
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
期数:
2024年11期
页码:
1576-1579
栏目:
综 述
出版日期:
2024-11-05

文章信息/Info

Title:
Research progress on the role and relationship between DNA damage response and aurora kinase family in tumorigenesis and development
作者:
陈永华1; 谢健龙2; 吴 琴2; 赵颖海3
(1.广东医科大学附属医院病理诊断与研究中心,广东 湛江 524001; 2.广东医科大学附属医院胸外科,广东 湛江 524001; 3.广东医科大学病理系,广东 湛江 524023)
Author(s):
CHEN Yonghua; XIE Jianlong; WU Qin; ZHAO Yinghai
(Department of Pathological Diagnosis and Research Center,Affiliated Hospital of Guangdong Medical University,Zhanjiang 524001,China)
关键词:
肿瘤;  DNA损伤反应;  极光激酶家族;  p53;  细胞周期蛋白依赖性激酶
Keywords:
Tumor;  DNA damage response;  Aurora kinase;  p53;  Cyclin-dependent kinase
分类号:
R 730.2
DOI:
DOI:10.3969/j.issn.1000-7377.2024.11.030
文献标志码:
A
摘要:
DNA是遗传信息的载体,其结构的稳定性对维持生命至关重要。当内源性或外源性因素引起DNA损伤时,细胞会启动DNA损伤反应(DDR)机制进行修复,从而使细胞停留在分裂间期或死亡。但在肿瘤细胞中,往往存在DDR抑制或突变,导致肿瘤细胞恶性增殖。极光激酶(AURK)家族是一类与有丝分裂过程密切相关的蛋白激酶。研究发现,AURK家族在肿瘤细胞中出现异常表达,并且与DDR相关分子p53和细胞周期蛋白依赖性激酶(CDKs)存在密切联系。因此,现就DDR和AURK家族在肿瘤发生与发展中的作用以及两者在肿瘤中的关系进行综述。
Abstract:
DNA is the carrier of genetic information,and the stability of its structure is essential for the maintenance of life.When DNA damage is caused by endogenous or exogenous factors,the cell will initiate the DNA damage response(DDR)mechanism to repair it,thus allowing the cell to stay in interphase or die.However,in tumour cells,DDR inhibition or mutations are often present,leading to malignant proliferation of tumour cells.Aurora kinase(AURK)family is a class of protein kinases that are closely related to the mitotic process.It has been found that that the AURK family is abnormally expressed in cancer cells and has a close relationship with DDR-related molecules such as p53 and cyclin-dependent kinases(CDKs).Therefore,this article reviews the roles of DDR and AURK family in tumourigenesis and development and the relationship between the two in cancer.

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备注/Memo

备注/Memo:
基金项目:广东省自然科学基金资助项目(2017A030313688)
更新日期/Last Update: 2024-11-04