[1]张文娟,王琰琰,周静祎,等.微小RNA-181c-5p和Kruppel样因子6在子宫内膜样腺癌组织中的表达及其与患者临床病理特征关系研究[J].陕西医学杂志,2024,(4):552-555.[doi:DOI:10.3969/j.issn.1000-7377.2024.04.026]
　ZHANG Wenjuan,WANG Yanyan,ZHOU Jingyi,et al.Expression of miR-181c-5p and Kruppel-like transcription factor 6 and its relationship with clinicopathological features in endometrioid carcinoma tissues[J].,2024,(4):552-555.[doi:DOI:10.3969/j.issn.1000-7377.2024.04.026]
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微小RNA-181c-5p和Kruppel样因子6在子宫内膜样腺癌组织中的表达及其与患者临床病理特征关系研究
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
期数:
2024年4期
页码:
552-555
栏目:
临床病理
出版日期:
2024-04-05

文章信息/Info

Title:
Expression of miR-181c-5p and Kruppel-like transcription factor 6 and its relationship with clinicopathological features in endometrioid carcinoma tissues
作者:
张文娟; 王琰琰; 周静祎; 关雪岩
(锦州医科大学附属第一医院妇产科,辽宁 锦州 121000)
Author(s):
ZHANG Wenjuan; WANG Yanyan; ZHOU Jingyi; GUAN Xueyan
(Department of Obstetrics and Gynecology,First Affiliated Hospital of Jinzhou Medical University,Jinzhou 121000,China)
关键词:
肿瘤;  子宫内膜样腺癌;  微小RNA-181c-5p;  Kruppel样因子6;  相关性;  预后
Keywords:
Neoplasm;  Endometrioid carcinoma;  miR-181c-5p;  KLF-6;  Correlation;  Prognosis
分类号:
R 737.33
DOI:
DOI:10.3969/j.issn.1000-7377.2024.04.026
文献标志码:
A
摘要:
目的:检测子宫内膜样腺癌组织中微小RNA-181c-5p(miR-181c-5p)和Kruppel样因子6(KLF6)的表达,探讨其相关性及临床意义。方法:选择49例子宫内膜样腺癌行手术治疗的患者作为观察组,选择49例增生期子宫内膜组织作为对照组。应用实时荧光定量PCR法检测术后组织中miR-181c-5p的表达,应用免疫组化方法检测KLF6的表达。应用线性相关分析观察miR-181c-5p和KLF6的关系,应用K-M生存分析观察miR-181c-5p和KLF6与术后生存时间的关系。结果:观察组miR-181c-5p表达量明显低于对照组(P<0.05),KLF6的阳性率明显低于对照组(P<0.05)。观察组miR-181c-5p与KLF6表达与肿瘤肌层浸润深度、宫颈管累犯及病理分级密切相关(均P<0.05),且两者具有正相关性,两者的表达与术后生存时间相关(均P<0.05)。结论:子宫内膜样腺癌中miR-181c-5p和KLF6均异常表达且具有正相关性,联合检测miR-181c-5p和KLF6的表达对判断肿瘤预后可能有一定价值。
Abstract:
Objective:To detect the expression of microRNA-181c-5p(miR-181c-5p)and Kruppel like factor 6(KLF6)in endometrioid carcinoma,explore their correlation and clinical significance.Methods:49 cases of endometrioid carcinoma were selected as the observation group,and 49 cases of normal proliferative endometrial tissue were selected as the control group.The expression of miR-181c-5p was detected by RT-qPCR method.KLF6 was detected by immunohistochemistry method.Linear correlation analysis was used to observe the relationship between miR-181c-5p and KLF6,and K-M survival analysis was used to observe the relationship between miR-181c-5p and KLF6 and survival time.Results:Expression of miR-181c-5p was significantly lower in the observation group than that in the control group(P<0.05).Positive rate of KLF6 was significantly lower in the observation group than that in the control group(P<0.05).The expressions of miR-181c-5p and KLF6 were closely related to the depth of tumor invasion,cervical canal recidivism and pathological grade in observation group(all P<0.05).Positive correlation was found between miR-181c-5p and KLF6(P<0.05).The expression of miR-181c-5p and KLF6 were correlated with survival time(all P<0.05).Conclusion:Abnormal expression and positive correlation are found between miR-181c-5p and KLF6 in endometrioid carcinoma.Combined detection of miR-181c-5p and KLF6 may have a certain value in judging the prognosis on endometrial carcinoma.

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备注/Memo

备注/Memo:
基金项目:辽宁省科技计划联合计划(基金)项目(2023-MSLH-056); 辽宁省锦州市指导性科技计划项目(JZ2023B072)
更新日期/Last Update: 2024-04-07