[1]任妙,马庆芳.PRF牙髓血运重建术联合二联抗生素糊剂治疗年轻恒牙牙髓坏死临床价值研究[J].陕西医学杂志,2026,(2):248-252.[doi:DOI:10.3969/j.issn.1000-7377.2026.02.019]
　REN Miao,MA Qingfang.Clinical value of PRF pulpal revascularization combined with double-antibiotic paste in the treatment of pulpal necrosis of immature permanent teeth[J].,2026,(2):248-252.[doi:DOI:10.3969/j.issn.1000-7377.2026.02.019]
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PRF牙髓血运重建术联合二联抗生素糊剂治疗年轻恒牙牙髓坏死临床价值研究

《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
期数:
2026年2期
页码:
248-252
栏目:
药物与临床
出版日期:
2026-02-05

文章信息/Info

Title:
Clinical value of PRF pulpal revascularization combined with double-antibiotic paste in the treatment of pulpal necrosis of immature permanent teeth
作者:
任妙1; 马庆芳2
（1.杭州口腔医院，浙江 杭州 310006；2.浙江大学医学院附属邵逸夫医院，浙江 杭州 310016）
Author(s):
REN Miao1; MA Qingfang2
(1.Hangzhou Stomatology Hospital,Hangzhou 310006,China;2.Sir Run Run Shaw Hospital,Zhejiang University School of Medicine,Hangzhou 310016,China)
关键词:
牙髓坏死; 年轻恒牙; 富血小板纤维蛋白; 牙髓血运重建术; 二联抗生素糊剂; 炎症反应
Keywords:
Pulpal necrosis; Immature permanent teeth; Platelet-rich fibrin; Pulpal revascularization; Double-antibiotic paste; Inflammatory response
分类号:
R 781.3
DOI:
DOI:10.3969/j.issn.1000-7377.2026.02.019
文献标志码:
A
摘要:
目的：探讨富血小板纤维蛋白（PRF）牙髓血运重建术联合二联抗生素糊剂治疗年轻恒牙牙髓坏死的临床价值。方法：选取90例年轻恒牙牙髓坏死患者，随机分两组，各45例，即对照组（常规牙髓血运重建术联合二联抗生素糊剂）和观察组（PRF牙髓血运重建术联合二联抗生素糊剂）。评估两组患者临床疗效、不良反应、牙髓活力。比较两组患者治疗前后根管壁厚度、牙根长度、咬合力、牙周指标及血清炎症因子水平变化。结果：两组总有效率、牙髓活力阳性率、总不良反应率比较无统计学差异（均P＞0.05）。经治疗，根管壁厚度、咬合力、牙根长度改善程度比较，观察组优于对照组；观察组龈沟出血指数（SBI）、菌斑指数（PLI）、牙周探诊深度（PD）及血清白细胞介素-1β（IL-1β）、IL-8、肿瘤坏死因子-α（TNF-α）水平低于对照组（均P＜0.05）。结论：PRF牙髓血运重建术联合二联抗生素糊剂治疗年轻恒牙牙髓坏死效果较好，可降低炎症反应，促进牙根发育和根管壁增厚，提高牙齿咬合力。
Abstract:
Objective:To investigate the clinical value of platelet-rich fibrin (PRF) pulpal revascularization combined with double-antibiotic paste in the treatment of pulpal necrosis of immature permanent teeth.Methods：Ninety patients with pulpal necrosis of immature permanent teeth were selected and randomly divided into two groups of 45 cases each,namely the control group (conventional pulpal revascularization combined with double-antibiotic paste) and the observation group (PRF pulpal revascularization combined with double-antibiotic paste).The clinical efficacy,adverse reactions and pulpal vitality of the two groups were evaluated.Root-canal-wall thickness,root length,occlusal force,periodontal indices and serum inflammatory factor levels before and after treatment were compared between the two groups.Results:No statistically significant differences were found between the two groups in total effective rate,positive rate of pulpal vitality or total adverse-reaction rate (all P>0.05).After treatment,the improvements in root-canal-wall thickness,occlusal force and root length in the observation group were superior to those in the control group; the sulcus bleeding index (SBI),plaque index (PLI),periodontal probing depth (PD) and serum levels of interleukin-1β (IL-1β),IL-8 and tumour necrosis factor-α (TNF-α) in the observation group were lower than those in the control group (all P<0.05).Conclusion:PRF pulpal revascularization combined with double-antibiotic paste demonstrates favourable efficacy in the treatment of pulpal necrosis of immature permanent teeth,reducing inflammatory response,promoting root development and root-canal-wall thickening,and increasing tooth occlusal force.

参考文献/References:

[1]YILMAZ M,AKSU S,KARAHAN F,et al.Association between serum cytokine levels with pulp necrosis and apical periodontitis in sickle cell disease[J].Sci Rep,2025,15(1):41149.
[2]王珺,周媛媛,孙中毅,等.iRoot BP Plus应用于年轻恒牙血运重建术对患者牙根发育及龈沟液血管内皮生长因子、碱性成纤维细胞生长因子、白细胞介素-8、白细胞介素-1β水平的影响[J].陕西医学杂志,2024,53(4):531-535.
[3]应晓敏,朱国红,崔婷.PRF牙髓血运重建术治疗年轻恒牙牙髓坏死伴根尖病疗效观察[J].中国美容医学,2025,34(9):167-170.
[4]王珏,包炯.比较三联/二联抗生素糊剂用于年轻恒牙牙髓血运重建疗效及bFGF、VEGF水平变化研究[J].口腔医学,2022,42(8):723-726.
[5]王晓颖,王变红,王艳华.牙髓血运重建术治疗年轻恒牙外伤继发性牙髓坏死疗效观察[J].中国美容医学,2024,33(10):150-153.
[6]陆瑾慧,钱军,刘鹤,等.富血小板纤维蛋白应用于年轻恒牙牙髓血运重建术的临床研究[J].北京大学学报（医学版）,2018,50(4):672-679.
[7]李娇娇,黎淑芳.富血小板纤维蛋白应用于牙髓再生的研究进展[J].医学综述,2018,24(1):107-111.
[8]何继红,胡娟,王莹莹,等.铒激光联合血运重建对牙髓坏死的年轻恒牙根管壁厚度及炎性因子水平的影响[J].口腔材料器械杂志,2025,34(1):38-42.
[9]SAOUD T M A,RICUCCI D,LIN L M,et al.Regeneration and repair in endodontics-a special issue of the regenerative endodontics-a new era in clinical endodontics[J].Dent J (Basel),2016,4(1):3.
[10]郑建英,张霞.超声下根管中药失活剂联合次氯酸钠荡洗治疗儿童乳牙牙髓炎临床研究[J].陕西中医,2021,42(10):1426-1428.
[11]SAKO H,OMORI K,SHINODA-ITO Y,et al.Histopathological study of regenerative endodontic therapy on an immature mandibular second premolar with pulp necrosis:A case report[J].Cureus,2025,17(10):e95647.
[12]ARIFIN F A,MATSUDA Y,NATSIR N,et al.Comparison of oral health-related quality of life among endodontic patients with irreversible pulpitis and pulp necrosis using the oral health-related endodontic patient’s quality of life scale[J].Odontology,2025,113(2):844-856.
[13]李杨,李虎,赵梦珺,等.牙髓血运重建术和氢氧化钙根管封药方法治疗年轻恒牙牙髓坏死的效果[J].影像科学与光化学,2022,40(6):1576-1580.
[14]郝志庭,高水仙,曹溪溪.Vitapex、MTA联合氢氧化钙糊剂在年轻恒牙牙髓坏死牙髓血运重建中的效果[J].中国现代医学杂志,2024,34(24):75-80.
[15]刘虹秀,单轶,包春艳,等.Nd:YAP激光与三联抗生素糊剂在年轻恒牙牙髓血运重建术中消毒效果的对比分析[J].中国美容医学,2024,33(9):130-134.
[16]邓雪莲,刘泉,覃聪琦,等.富血小板纤维蛋白牙髓血运重建术在年轻恒牙根尖周病中的应用效果及对牙髓活力、根管钙化的影响[J].西部医学,2025,37(10):1534-1538.
[17]陈蕾,温涛,李雅彬.富血小板纤维蛋白在牙体牙髓治疗中的应用进展[J].中华老年口腔医学杂志,2020,18(1):52-56.
[18]王菲菲,王洁,张丽杰,等.牙髓血运重建术联合二联抗生素糊剂治疗年轻恒牙牙髓坏死临床评价[J].中国药业,2020,29(24):76-79.
[19]刘海鹏,孙丽娜,马宁.TAP、DAP、氢氧化钙对牙周成纤维细胞的毒性作用[J].临床口腔医学杂志,2018,34(11):652-655.
[20]刘燕,何敏,吴於芝.富血小板纤维蛋白牙髓血运重建术联合二联抗生素糊剂治疗年轻恒牙牙髓坏死价值研究[J].创伤与急危重病医学,2020,8(1):45-47.
[21]王小黎,徐丽,张容秀,等.Vitapex对年轻恒牙牙髓血运重建术疗效的影响[J].中华全科医学,2020,18(5):727-729,756.
[22]付钰,束明阳,杨波.即刻种植联合富血小板纤维蛋白固定种植体在前牙缺失治疗中的疗效及对患者龈沟液骨桥蛋白的影响[J].陕西医学杂志,2024,53(1):51-54.
[23]BHAVSAR B A,JAIN V,KUMARI A,et al.Evaluate the antimicrobial properties of double antibiotic paste (DAP) and morinda citrifolia and propolis paste (MCP) used in regenerative endodontics:An in vitro study[J].J Pharm Bioallied Sci,2025,17(1):703-705.
[24]李媛,高瞻,王荣耀,等.富血小板纤维蛋白复合白蛋白凝胶的基础与临床研究进展[J].空军军医大学学报,2025(10):1390-1395.
[25]从兆霞,韩婧,刘媛,等.运用富血小板血浆或富血小板纤维蛋白与传统的血凝块作为支架重建牙髓血运比较的Meta分析[J].中华生物医学工程杂志,2021,27(2):150-155.
[26]解碧晶,张钰涓.PRF及MTA材料支架和iRoot BP Plus支架在年轻恒牙再生性牙髓治疗中的应用[J].海南医学,2022,33(7):898-901.
[27]吴桂堂,周黎黎.富血小板纤维蛋白应用于年轻恒牙急性牙髓炎治疗的临床效果观察[J].浙江医学,2022,44(7):742-744.
[28]买布拜木·买买提依明,玛衣努尔·艾赛提,帕吾孜叶·帕尔哈提,等.富血小板纤维蛋白用于牙髓坏死的年轻恒牙患儿血管再生情况的随访分析[J].口腔医学,2025,45(3):175-179,184.

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备注/Memo

备注/Memo:
国家自然科学基金资助项目（81870765）
更新日期/Last Update: 2026-02-04