[1]王 珺,周媛媛,孙中毅,等.iRoot BP Plus应用于年轻恒牙血运重建术对患者牙根发育及龈沟液血管内皮生长因子、碱性成纤维细胞生长因子、白细胞介素-8、白细胞介素-1β水平的影响[J].陕西医学杂志,2024,(4):531-535.[doi:DOI:10.3969/j.issn.1000-7377.2024.04.021]
　WANG Jun,ZHOU Yuanyuan,SUN Zhongyi,et al.Effect of iRoot BP Plus application in young permanent teeth revascularization surgery on root development and levels of VEGF,bFGF,IL-8 and IL-1β in gingival crevicular fluid[J].,2024,(4):531-535.[doi:DOI:10.3969/j.issn.1000-7377.2024.04.021]
点击复制

iRoot BP Plus应用于年轻恒牙血运重建术对患者牙根发育及龈沟液血管内皮生长因子、碱性成纤维细胞生长因子、白细胞介素-8、白细胞介素-1β水平的影响
分享到：

《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
期数:
2024年4期
页码:
531-535
栏目:
临床研究
出版日期:
2024-04-05

文章信息/Info

Title:
Effect of iRoot BP Plus application in young permanent teeth revascularization surgery on root development and levels of VEGF,bFGF,IL-8 and IL-1β in gingival crevicular fluid
作者:
王 珺; 周媛媛; 孙中毅; 郑艳佳
(佳木斯市中心医院口腔科,黑龙江 佳木斯 154002)
Author(s):
WANG Jun; ZHOU Yuanyuan; SUN Zhongyi; ZHENG Yanjia
(Department of Stomatology,Jiamusi Central Hospital,Jiamusi 154002,China)
关键词:
年轻恒牙;  血运重建术;  iRoot BP Plus;  牙根发育;  血管内皮生长因子;  碱性成纤维细胞生长因子;  白细胞介素-8;  白细胞介素-1β
Keywords:
Young permanent teeth;  Revascularization surgery;  IRoot BP Plus;  Root development;  Vascular endothelial growth factor;  Basic fibroblast growth factor;  Interleukin-8;  Interleukin-1β
分类号:
R 782.1
DOI:
DOI:10.3969/j.issn.1000-7377.2024.04.021
文献标志码:
A
摘要:
目的:探讨iRoot BP Plus应用于年轻恒牙血运重建术对牙根发育及龈沟液血管内皮生长因子(VEGF)、碱性成纤维细胞生长因子(bFGF)、白细胞介素-8(IL-8)、白细胞介素-1β(IL-1β)水平的影响。方法:选取88例年轻恒牙血运重建术患儿作为研究对象,按照随机数字表法将其分为对照组(44例,44颗牙)和试验组(44例,44颗牙)。对照组使用无机三氧化物聚合物(MTA)作为填充材料,试验组选择iRoot BP Plus作为填充材料,两组术后均随访1年。比较两组随访1年后的疗效、牙根发育情况,术前、随访1年后的牙根长度、根管壁厚度、咬合功能、咀嚼功能、疼痛程度、牙周指数,术前、术后1周的龈沟液VEGF、bFGF、IL-8、IL-1β水平及随访期间的不良反应发生情况。结果:随访1年后,试验组总有效率及牙根发育Ⅰ型患儿占比分别为95.45%、47.73%,高于对照组的79.55%、25.00%(均P<0.05)。与术前比较,随访1年后,两组牙根长度、根管壁厚度增加,试验组高于对照组(均P<0.05); 两组咬合功能、咀嚼功能、视觉模拟评分法(VAS)、牙周袋深度(PD)、牙龈指数(GI)、龈沟出血指数(SBI)、菌斑指数(PLI)评分降低,试验组低于对照组(均P<0.05)。与术前比较,术后1周,两组龈沟液VEGF、bFGF水平升高,试验组高于对照组(均P<0.05); 两组龈沟液IL-8、IL-1β水平降低,试验组低于对照组(均P<0.05)。随访期间,试验组不良反应总发生率为4.55%,低于对照组的22.73%(P<0.05)。结论:与MTA比较,iRoot BP Plus应用于年轻恒牙血运重建术中可调节患儿龈沟液VEGF、bFGF、IL-8、IL-1β水平,减轻炎症,促进牙根生长发育,并可减轻患儿疼痛程度,改善咬合功能、咀嚼功能及牙周状况,进而有利于提高疗效,且具有较好的安全性。
Abstract:
Objective:To investigate the effect of iRoot BP Plus application in young permanent teeth revascularization surgery on root development and levels of vascular endothelial growth factor(VEGF),basic fibroblast growth factor(bFGF),interleukin-8(IL-8),and interleukin-1β(L-1β)in gingival crevicular fluid.Methods:88 young permanent tooth revascularization children were selected as the study subjects and randomly divided into the control group(44 cases,44 teeth)and the experimental group(44 cases,44 teeth)using a random number table method.The control group used mineral trioxide aggregate(MTA)as the filling material,while the experimental group chose iRoot BP Plus as the filling material.Both groups were followed up for 1 year after surgery.The efficacy and root development after 1 year of followed up,the root length,root canal wall thickness,occlusal function,chewing function,level of pain,periodontal index before surgery and after 1 year of followed up,and the levels of VEGF,bFGF,IL-8,IL-1β in gingival crevicular fluid before and 1 week after surgery and incidence of complications during followed up of two groups were ompared.Results:After 1 year of followed up,the total effective rate and the proportion of children with type Ⅰ root development in the experimental group were 95.45% and 47.73% respectively,higher than the control group's 79.55% and 25.00%(all P<0.05).Compared with before surgery,after 1 year of followed up,the root length and root canal wall thickness of the two groups increased,with the experimental group being higher(all P<0.05); the scores of occlusal function,chewing function,visual analogue scale(VAS),periodontal pocket depth(PD),Gingival Index(GI),Sulcus Bleeding Index(SBI),and plaque index(PLI)decreased in both groups,with the experimental group showing lower(all P<0.05).Compared with before surgery,the levels of VEGF and bFGF in the gingival crevicular fluid of the two groups increased after 1 week after surgery,the experimental group was higher(all P<0.05); the levels of IL-8 and IL-1β in gingival crevicular fluid decreased in both groups,the experimental group was lower(all P<0.05).During the followed up period,the total incidence of complications in the experimental group was 4.55%,lower than the 22.73% in the control group(P<0.05).Conclusion:Compared with MTA,iRoot BP Plus could regulate the levels of VEGF,bFGF,IL-8,and IL-1β in the gingival crevicular fluid of young permanent teeth during revascularization surgery of childrens,reduce inflammation,promote root growth and development,reduce children pain,improve occlusal function,chewing function and periodontal condition,with safety.

参考文献/References:

[1] 李文静,李浩渤,刘从娜,等.不同生物活性支架治疗年轻恒牙再生牙髓活力的比较[J].中国组织工程研究,2021,25(4):499-503.
[2] CEHRELI Z C,UNVERDI G E,BALLIKAYA E.Deciduous tooth pulp autotransplantation for the regenerative endodontic treatment of permanent teeth with pulp necrosis:A case series[J].J Endod,2022,48(5):669-674.
[3] HUANG Y,TANG X,CEHRELI Z C,et al.Autologous transplantation of deciduous tooth pulp into necrotic young permanent teeth for pulp regeneration in a dog model[J].J Int Med Res,2019,47(10):5094-5105.
[4] 王珏,包炯.比较三联/二联抗生素糊剂用于年轻恒牙牙髓血运重建疗效及bFGF、VEGF水平变化研究[J].口腔医学,2022,42(8):723-726.
[5] 刘帆,宋楠,冯瑶,等.iRoot BP与MTA治疗年轻恒牙意外露髓的近期及远期效果对比分析[J].川北医学院学报,2021,36(7):846-849.
[6] 严飞,姚宁.iRoot BP Plus与MTA行年轻恒牙血运重建术的效果对比分析[J].口腔医学,2022,42(3):230-234.
[7] 曹采方.牙周病学[M].2版.北京:人民卫生出版社,2003:15-23.
[8] 孙明,王蔚文.临床疾病诊断及疗效判定标准[M].北京:中国科学技术文献出版社,2010:123-126.
[9] 严广斌.视觉模拟评分法[J].中华关节外科杂志:电子版,2014,8(2):273.
[10] 尹秋蓉,张旭凤,吴芸菲.热牙胶垂直加压法与iRoot SP冷侧压法行C形根管充填治疗恒牙根尖周炎疗效及对疼痛和预后的影响[J].河北医学,2022,28(6):983-988.
[11] 卢艳红,王静,吴晓光.iRoot BP Plus在年轻恒牙活髓切断术中的临床效果及美观性观察[J].中国美容医学,2022,31(10):141-144.
[12] 郑建英,张霞.超声下根管中药失活剂联合次氯酸钠荡洗治疗儿童乳牙牙髓炎临床研究[J].陕西中医,2021,42(10):1426-1428.
[13] 马雪飞,周瑾,吴佩玲.两种材料用于年轻恒牙直接盖髓的临床疗效[J].临床口腔医学杂志,2021,37(10):595-597.
[14] 邱勇棋.牙周源性牙周牙髓联合病变根管治疗后牙周治疗时机选择及效果观察[J].陕西医学杂志,2018,47(3):353-355.
[15] 赵燕霞,张沛.年轻恒牙活髓切断术中应用盖髓剂iRoot BP Plus疗效观察[J].中华实用诊断与治疗杂志,2021,35(10):1029-1032.
[16] 杜小沛,张婷婷,韩宇,等.iRoot SP配合不同根管充填方法在牙体牙髓病治疗中的应用[J].临床口腔医学杂志,2021,37(7):430-433.
[17] 叶琴,刘慧,刘玉秀,等.三氧化物凝聚体在年轻恒牙根尖诱导成形术中的应用[J].中国美容医学,2020,29(3):112-114.
[18] 杨光,尹雪莲,马东杰,等.三氧化聚合物MTA在年轻恒牙活髓保存术后的治疗效果及对牙髓干细胞体外增殖分化的影响[J].湖南师范大学学报(医学版),2020,17(1):15-18.
[19] 陈卫卫,任志明,赵连生.生物陶瓷iRoot BP Plus活髓切断即刻修复术治疗年轻恒牙冠折的效果及对疼痛症状的影响[J].临床和实验医学杂志,2021,20(4):440-443.
[20] 张小芳,刘朝进,李祖进,等.iRoot BP Plus用于外伤露髓年轻恒牙活髓切断术对牙齿变色率及根管钙化的影响[J].口腔材料器械杂志,2022,31(4):301-304.
[21] 张艳梅,操小马,王艳平.Nd:YAG激光照射联合iRoot BP Plus材料行直接盖髓术治疗龋源性牙髓炎对患者炎症水平及牙髓活力的影响[J].临床和实验医学杂志,2023,22(2):202-206.
[22] 孟红军,王守儒.养阴清火方治疗慢性牙周炎疗效及对患者TNF-α、IL-1β、IL-6影响的研究[J].陕西中医,2018,39(12):1731-1734.
[23] 张海龙,陈雪,王敬,等.IRoot BP Plus和三氧化矿物凝聚体用于活髓切断术治疗年轻恒牙冠折露髓的临床研究[J].中国医刊,2022,57(1):109-112.
[24] 孟丹婕,杨英泽,周一闻,等.iRoot BP Plus用于恒牙深龋选择性去龋后间接牙髓治疗的临床疗效评估[J].临床口腔医学杂志,2023,39(10):617-620.
[25] 王雪,王诗维.iRoot BP Plus在根管内血运重建术中的效果研究[J].实用临床医药杂志,2021,25(4):15-18.

备注/Memo

备注/Memo:
基金项目:黑龙江省卫生健康委员会科研项目(20220808011164)
更新日期/Last Update: 2024-04-07