[1]杨世伟,杨添淞,冯楚文,等.磷酸酶及张力蛋白同源物诱导激酶/帕金森病蛋白介导的线粒体自噬对患者心肌损伤产生影响的研究进展[J].陕西医学杂志,2024,(4):569-572.[doi:DOI:10.3969/j.issn.1000-7377.2024.04.030]
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磷酸酶及张力蛋白同源物诱导激酶/帕金森病蛋白介导的线粒体自噬对患者心肌损伤产生影响的研究进展
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
期数:
2024年4期
页码:
569-572
栏目:
综 述
出版日期:
2024-04-05

文章信息/Info

作者:
杨世伟1杨添淞2冯楚文2王辰庚1赵鑫宇1兰闻禹1张 红1李书霖2
(1.黑龙江中医药大学研究生院,黑龙江 哈尔滨 150040; 2.黑龙江中医药大学附属第一医院,黑龙江 哈尔滨 150040)
关键词:
心肌损伤 自噬 线粒体 磷酸酶及张力蛋白同源物诱导激酶 帕金森病蛋白
分类号:
R 542.2
DOI:
DOI:10.3969/j.issn.1000-7377.2024.04.030
文献标志码:
A
摘要:
心肌损伤是缺血缺氧性心血管疾病及感染心肌疾病患者常见并发症,会严重影响患者生活质量和预后,也是目前疾病治疗过程中需要重点关注的并发症之一。线粒体作为心肌细胞代谢的重要能量供应者,其自噬激活在心肌损伤的发生发展中扮演重要角色。第10号染色体缺失的磷酸酶及张力蛋白同源基因诱导激酶1(PINK1)/帕金森病蛋白(Parkin)介导是线粒体自噬的经典途径之一,也是目前研究最清楚的线粒体自噬途径。PINK1/Parkin介导的线粒体自噬激活程度不同会导致其在心肌损伤发生中的作用不同,适度PINK1/Parkin介导的线粒体对心肌损伤具有保护作用,但过度激活会促进心肌损伤发生,或加重心肌损伤。因此,了解PINK1/Parkin介导的线粒体自噬在心肌损伤中具体调控机制,对心肌损伤防治具有重要临床指导价值。

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备注/Memo

备注/Memo:
基金项目:黑龙江省自然科学基金资助项目(LH2021H093)
更新日期/Last Update: 2024-04-07