[1]杨 静,郭 永,郭润民.孕早期孕妇促甲状腺激素、甲状腺过氧化物酶抗体及微小RNA-873-5p水平与妊娠期糖尿病相关性研究[J].陕西医学杂志,2024,(4):479-482,495.[doi:DOI:10.3969/j.issn.1000-7377.2024.04.009]
　YANG Jing,GUO Yong,GUO Runmin.Correlation between TSH,TPOAb,miR-873-5p levels in early pregnancy and gestational diabetes mellitus[J].,2024,(4):479-482,495.[doi:DOI:10.3969/j.issn.1000-7377.2024.04.009]
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孕早期孕妇促甲状腺激素、甲状腺过氧化物酶抗体及微小RNA-873-5p水平与妊娠期糖尿病相关性研究
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
期数:
2024年4期
页码:
479-482,495
栏目:
临床研究
出版日期:
2024-04-05

文章信息/Info

Title:
Correlation between TSH,TPOAb,miR-873-5p levels in early pregnancy and gestational diabetes mellitus
作者:
杨 静1; 2; 郭 永1; 3; 郭润民2
(1.潍坊医学院,山东 潍坊 261000; 2.广东医科大学顺德妇女儿童医院产科,广东 佛山 528300; 3.潍坊市妇幼保健院产科,山东 潍坊 261000)
Author(s):
YANG Jing; GUO Yong; GUO Runmin
(Weifang Medical University,Weifang 261000,China)
关键词:
孕早期;  妊娠期糖尿病;  促甲状腺激素;  甲状腺过氧化物酶抗体;  微小RNA-873-5p;  相关性
Keywords:
Early pregnancy;  Gestational diabetes mellitus;  Thyroid stimulating hormone;  Thyroid peroxidase antibody;  microRNA-873-5p;  Correlation
分类号:
R 714.2
DOI:
DOI:10.3969/j.issn.1000-7377.2024.04.009
文献标志码:
A
摘要:
目的:分析研究孕早期促甲状腺激素(TSH)、甲状腺过氧化物酶抗体(TPOAb)及微小RNA-873-5p(miR-873-5p)水平与妊娠期糖尿病(GDM)的相关性。方法:选取定期产检的GDM孕妇命名为GDM组(n=109),另选同期在本院产检的糖耐量正常孕妇为对照组(n=60)。收集两组孕妇的一般资料及孕早期实验室检测指标(TSH、TPOAb、miR-873-5p),采用单因素、多因素分析TSH、TPOAb、miR-873-5p水平与GDM的关系; 并绘制ROC曲线分析血清TSH、TPOAb、miR-873-5p水平对GDM的预测价值。结果:GDM组的血清TSH、TPOAb、miR-873-5p水平均高于对照组,差异具有统计学意义(均P<0.05); 多因素Logistic回归分析显示,年龄>30岁(OR=1.982)、孕前BMI≥24 kg/m2(OR=2.020)、TSH升高(OR=2.113)、TPOAb升高(OR=2.307)及miR-873-5p水平升高(OR=2.059)是发生GDM的独立危险因素(均P<0.05); ROC曲线分析显示,血清TSH、TPOAb、miR-873-5p及联合检测的曲线下面积(AUC)分别为0.830、0.829、0.762、0.936,联合检测优于单一检测(P<0.05)。结论:TSH、TPOAb及miR-873-5p在GDM孕妇体内呈高表达,可能成为GDM发生的辅助预测指标。
Abstract:
Objective:To analyze the correlation between the levels of thyroid stimulating hormone(TSH),thyroid peroxidase antibody(TPOAb),miR-873-5p in early pregnancy and gestational diabetes mellitus(GDM).Methods:Pregnant women with GDM who underwent regular antennalexaminations were selected as GDM group(n=109),and pregnant women with normal glucose tolerance who underwent antennalexaminations during the same period were selected as control group(n=60).The general data and early pregnancy laboratory detection indicators(TSH,TPOAb,miR-873-5p)of the two groups were collected,and the relationship between the levels of TSH,TPOAb,miR-873-5p and GDM was analyzed by univariate and multivariate analysis.ROC curve was drawn to analyze the predictive value of serum TSH,TPOAb and miR-873-5p levels on GDM. Results:The levels of serum TSH,TPOAb and miR-873-5p in GDM group were higher than those in control group,with statistical significance(P<0.05).Multivariate Logistic regression analysis showed that Age>30 years old(OR=1.982),pregnancy BMI ≥24 kg/m2(OR=2.020),elevated TSH(OR=2.113),elevated TPOAb(OR=2.307)and elevated miR-873-5p(OR=2.059)were independent risk factors for GDM(all P<0.05).ROC curve analysis showed that the area under the curve(AUC)of serum TSH,TPOAb,miR-873-5p and combined detection were 0.830,0.829,0.762,0.936,respectively,and combined detection was superior to single detection(P<0.05).Conclusion:TSH,TPOAb and miR-873-5p are highly expressed in pregnant women with GDM,which may be auxiliary predictors of the occurrence of GDM.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金资助项目(81873649)
更新日期/Last Update: 2024-04-07