[1]高兰,林洋洋,陈宏,等.线粒体自噬在心血管疾病中的研究进展[J].陕西医学杂志,2026,(7):996-1000,1004.[doi:DOI:10.3969/j.issn.1000-7377.2026.07.022]
　GAO Lan,LIN Yangyang,CHEN Hong,et al.Research progress on role and mechanism of mitochondrial autophagy in cardiovascular diseases[J].,2026,(7):996-1000,1004.[doi:DOI:10.3969/j.issn.1000-7377.2026.07.022]
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线粒体自噬在心血管疾病中的研究进展

《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
期数:
2026年7期
页码:
996-1000,1004
栏目:
综述
出版日期:
2026-07-05

文章信息/Info

Title:
Research progress on role and mechanism of mitochondrial autophagy in cardiovascular diseases
作者:
高兰1; 林洋洋2; 陈宏2; 寇俊萍2; 李芳1; 2
(1.中国药科大学附属江宁中医院 南京市江宁中医院，江苏 南京 211198；2.中国药科大学中药学院中药药理与中医药学系，江苏 南京 211198)
Author(s):
GAO Lan1; LIN Yangyang2; CHEN Hong2; KOU Junping2; LI Fang1; 2
(1.Affiliated Jiangning Hospital of Chinese Medicine,School of Traditional Chinese Pharmacy,China Pharmaceutical University,Nanjing 211198,China；2.School of Traditional Chinese Pharmacy,China Pharmaceutical University,Nanjing 211198,China)
关键词:
线粒体自噬; 心血管疾病; 动脉粥样硬化; 高血压症; 糖尿病心肌病; 缺血性心肌病; 心力衰竭
Keywords:
Mitochondrial autophagy; Cardiovascular disease; Atherosclerosis; Hypertension; Diabetic cardiomyopathy; Ischemic cardiomyopathy; Heart failure
分类号:
R 54
DOI:
DOI:10.3969/j.issn.1000-7377.2026.07.022
文献标志码:
A
摘要:
线粒体自噬是一种选择性降解机制，专门负责清除受损、多余或功能性退化的线粒体，以确保线粒体与细胞稳态的平衡。近年来研究发现，在动脉粥样硬化(AS)、高血压、糖尿病心脏病(DC)、缺血性心肌病(ICM)和心力衰竭(HF)等心血管疾病中，线粒体自噬的功能经常出现障碍，加剧了疾病的发展。因此，调节线粒体自噬的平衡和功能被认为是治疗心血管疾病的可能策略。现概述线粒体自噬在心血管疾病研究中作用研究进展，以期提供心血管疾病的预防和治疗新参考。
Abstract:
Mitochondrial autophagy,as a selective degradation mechanism,is responsible for removing and regulating damaged,redundant or functionally degraded mitochondria to ensure the balance between mitochondria and cell homeostasis.However,mitochondrial autophagy dysfunction will further aggravates the development of cardiovascular diseases such as arteriosclerosis(AS),hypertension,diabetic cardiomyopathy(DC),ischemic cardiomyopathy(ICM) and heart failure(HF),which is found in studies recently.Accordingly,regulating the balance and function of mitochondrial autophagy is considered as a possible strategy to treat cardiovascular diseases.This article reviews the research progress of mitochondrial autophagy in cardiovascular diseases,in order to provide new reference for the prevention and treatment of cardiovascular diseases.

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备注/Memo

备注/Memo:
国家自然科学基金资助项目（82574980,82274231）；中国药科大学附属江宁中医院科研项目资助（YJZD2025009）
更新日期/Last Update: 2026-07-10