参考文献/References:
[1]TURGUT F,AWAD A S,ABDEL-RAHMAN E M.Acute kidney injury:Medical causes and pathogenesis[J].Journal of Clinical Medicine,2023,12(1):375.
[2]SUSANTITAPHONG P,CRUZ D N,CERDA J,et al.World incidence of AKI:A meta-analysis[J].Clinical Journal of the American Society of Nephrology:CJASN,2013,8(9):1482-1493.
[3]KELLUM J A,LAMEIRE N,KDIGO AKI GUIDELINE WORK GROUP.Diagnosis,evaluation,and management of acute kidney injury:A KDIGO summary (part 1)[J].Critical Care (London,England),2013,17(1):204.
[4]GUO R,DUAN J,PAN S,et al.The road from AKI to CKD:Molecular mechanisms and therapeutic targets of ferroptosis[J].Cell Death and Disease,2023,14(7):426.
[5]BELAVGENI A,MEYER C,STUMPF J,et al.Ferroptosis and necroptosis in the kidney[J].Cell Chemical Biology,2020,27(4):448-462.
[6]LIU J,KANG R,TANG D.Signaling pathways and defense mechanisms of ferroptosis[J].FEBS Journal,2022,289(22):7038-7050.
[7]ZHANG W,LIU Y,LIAO Y,et al.GPX4,ferroptosis,and diseases[J].Biomedicine & Pharmacotherapy=Biomedecine & Pharmacotherapie,2024,174:116512.
[8]LI Y,ZENG X,LU D,et al.Erastin induces ferroptosis via ferroportin-mediated iron accumulation in endometriosis[J].Human Reproduction (Oxford,England),2021,36(4):951-964.
[9]MIOTTO G,ROSSETTO M,DI PAOLO M L,et al.Insight into the mechanism of ferroptosis inhibition by ferrostatin-1[J].Redox Biology,2020,28:101328.
[10]WANG D,LIANG W,HUO D,et al.SPY1 inhibits neuronal ferroptosis in amyotrophic lateral sclerosis by reducing lipid peroxidation through regulation of GCH1 and TFR1[J].Cell DEATH and DIFFERENTIATION,2023,30(2):369-382.
[11]CHEN J,OU Z,GAO T,et al.Ginkgolide B alleviates oxidative stress and ferroptosis by inhibiting GPX4 ubiquitination to improve diabetic nephropathy[J].Biomedicine & Pharmacotherapy=Biomedecine & Pharmacotherapie,2022,156:113953.
[12]DENG Z,ZENG W,GAO Y,et al.Mesenchymal stem cells prevent SLC39A14-dependent hepatocyte ferroptosis through exosomal miR-16-5p in liver graft[J].Advanced Science (Weinheim,Baden-wurttemberg,Germany),2025,12(6):e2411380.
[13]WU H,LIU Q,SHAN X,et al.ATM orchestrates ferritinophagy and ferroptosis by phosphorylating NCOA4[J].Autophagy,2023,19(7):2062-2077.
[14]WU J,LIU Q,ZHANG X,et al.The interaction between STING and NCOA4 exacerbates lethal sepsis by orchestrating ferroptosis and inflammatory responses in macrophages[J].Cell Death and Disease,2022,13(7):653.
[15]DING K,LIU C,LI L,et al.Acyl-CoA synthase ACSL4:An essential target in ferroptosis and fatty acid metabolism[J].Chinese Medical Journal,2023,136(21):2521-2537.
[16]WANG Y,ZHANG M,BI R,et al.ACSL4 deficiency confers protection against ferroptosis-mediated acute kidney injury[J].Redox Biology,2022,51:102262.
[17]LI W,LIANG L,LIU S,et al.FSP1:A key regulator of ferroptosis[J].Trends in Molecular Medicine,2023,29(9):753-764.
[18]CAO J,CHEN X,CHEN L,et al.DHODH-mediated mitochondrial redox homeostasis:A novel ferroptosis regulator and promising therapeutic target[J].Redox Biology,2025,85:103788.
[19]LIU Y,LU S,WU L L,et al.The diversified role of mitochondria in ferroptosis in cancer[J].Cell Death and Disease,2023,14(8):519.
[20]WANG D,LIANG W,HUO D,et al.SPY1 inhibits neuronal ferroptosis in amyotrophic lateral sclerosis by reducing lipid peroxidation through regulation of GCH1 and TFR1[J].Cell Death and Differentiation,2023,30(2):369-382.
[21]WU W,WANG X,YU X,et al.Smad3 signatures in renal inflammation and fibrosis[J].International Journal of Biological Sciences,2022,18(7):2795-2806.
[22]TIAN L,SHAO X,XIE Y,et al.Kidney injury molecule-1 is elevated in nephropathy and mediates macrophage activation via the mapk signalling pathway[J].Cellular Physiology and Biochemistry:International Journal of Experimental Cellular Physiology,Biochemistry,and Pharmacology,2017,41(2):769-783.
[23]MELCHINGER I,GUO K,LI X,et al.VCAM-1 mediates proximal tubule-immune cell cross talk in failed tubule recovery during AKI-to-CKD transition[J].American Journal of Physiology Renal Physiology,2024,327(4):f610-f622.
[24]NISHIZAWA H,YAMANAKA M,IGARASHI K.Ferroptosis:Regulation by competition between NRF2 and BACH1 and propagation of the death signal[J].FEBS Journal,2023,290(7):1688-1704.
[25]ZHANG Q,SUN T,YU F,et al.PAFAH2 suppresses synchronized ferroptosis to ameliorate acute kidney injury[J].Nature Chemical Biology,2024,20(7):835-846.
[26]ZHANG Y,MOU Y,ZHANG J,et al.Therapeutic implications of ferroptosis in renal fibrosis[J].Frontiers in Molecular Biosciences,2022,9:890766.
[27]CAO H,CHEN Y,HUANG J,et al.DKK3,regulated by FOXF1-EZH2 axis,takes action on tubular epithelial cells senescence to trigger glomerular endothelial cells ferroptosis involving in renal fibrosis[J].Mechanisms of Ageing and Development,2025,228:112103.
[28]PEI Z,QIN Y,FU X,et al.Inhibition of ferroptosis and iron accumulation alleviates pulmonary fibrosis in a bleomycin model[J].Redox Biology,2022,57:102509.
[29]ZHOU L,XUE X,HOU Q,et al.Targeting ferroptosis attenuates interstitial inflammation and kidney fibrosis[J].Kidney Diseases (Basel,Switzerland),2022,8(1):57-71.
[30]LIU Z,NAN P,GONG Y,et al.Endoplasmic reticulum stress-triggered ferroptosis via the XBP1-Hrd1-Nrf2 pathway induces EMT progression in diabetic nephropathy[J].Biomedicine & Pharmacotherapy=Biomedecine & Pharmacotherapie,2023,164:114897.
[31]ZHU Z,LI J,SONG Z,et al.Tetramethylpyrazine attenuates renal tubular epithelial cell ferroptosis in contrast-induced nephropathy by inhibiting transferrin receptor and intracellular reactive oxygen species[J].Clinical Science (London,England:1979),2024,138(5):235-249.
[32]GHAITH M M,EL-BOSHY M,ALMASMOUM H,et al.Deferasirox and vitamin D3 co-therapy mitigates iron-induced renal injury by enhanced modulation of cellular anti-inflammatory,anti-oxidative stress,and iron regulatory pathways in rat[J].Journal of Trace Elements in Medicine and Biology:Organ of the Society for Minerals and Trace Elements (GMS),2022,74:127085.
[33]LI S,HE Y,CHEN K,et al.RSL3 drives ferroptosis through NF-κB pathway activation and GPX4 depletion in glioblastoma[J].Oxidative Medicine and Cellular Longevity,2021,2021:2915019.
[34]MIOTTO G,ROSSETTO M,DI PAOLO M L,et al.Insight into the mechanism of ferroptosis inhibition by ferrostatin-1[J].Redox Biology,2020,28:101328.
[35]KAGAN V E,MAO G,QU F,et al.Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis[J].Nature Chemical Biology,2017,13(1):81-90.
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