[1]冯培东,张晓凤.铁死亡系统在急性肾损伤向慢性肾损伤转化中作用及治疗进展[J].陕西医学杂志,2026,(7):986-990.[doi:DOI:10.3969/j.issn.1000-7377.2026.07.020]
 FENG Peidong,ZHANG Xiaofeng.The Role of Ferroptosis in the AKI-to-CKD Transition[J].,2026,(7):986-990.[doi:DOI:10.3969/j.issn.1000-7377.2026.07.020]
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铁死亡系统在急性肾损伤向慢性肾损伤转化中作用及治疗进展

《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
期数:
2026年7期
页码:
986-990
栏目:
综述
出版日期:
2026-07-05

文章信息/Info

Title:
The Role of Ferroptosis in the AKI-to-CKD Transition
作者:
冯培东1张晓凤2
(1.陕西中医药大学,陕西 咸阳712046;2.陕西省中医医院,陕西 西安710003)
Author(s):
FENG Peidong1ZHANG Xiaofeng2
(1.Shaanxi University of Chinese Medicine,Xianyang 712046,China;2.Shaanxi Provincial Hospital of Traditional Chinese Medicine, Xi’an 710003,China)
关键词:
铁死亡急性肾损伤肾小管损伤肾纤维化炎症线粒体功能通路
Keywords:
FerroptosisAcute kidney injuryRenal tubular injuryRenal fibrosisInflammatoryMitochondrial dysfunctionSignaling pathways
分类号:
R 592
DOI:
DOI:10.3969/j.issn.1000-7377.2026.07.020
文献标志码:
A
摘要:
急性肾损伤(AKI)是慢性肾损伤(CKD)的重要危险因素,其机制复杂且缺乏有效干预策略。近年来研究表明,铁死亡(Ferroptosis)作为一种铁依赖性的调节性细胞死亡形式,在AKI向CKD转变过程中发挥关键作用。本文系统综述了铁死亡通过引起持续性肾小管损伤、放大炎症反应、促进纤维化及导致细胞周期停滞等机制推动疾病进展的病理生理过程,并总结了针对铁死亡关键通路(如System Xc --GSH-GPX4、FSP1-CoQ10等)的潜在治疗策略,包括铁螯合剂、抗氧化剂、GPX4激活剂等,为临床防治AKI-CKD转变提供新思路。
Abstract:
Acute kidney injury (AKI) is an important risk factor for chronic kidney disease (CKD),with complex mechanisms and a lack of effective intervention strategies.Recent studies have shown that ferroptosis,as an iron-dependent form of regulatory cell death,plays a key role in the transition from AKI to CKD.This article systematically reviews the pathophysiological processes of ferroptosis promoting disease progression by causing persistent tubular damage,amplifying inflammatory responses,promoting fibrosis,and leading to cell cycle arrest,and summarizes potential therapeutic strategies for key ferroptosis pathways (such as SystemXc--GSH-GPX4,FSP1-CoQ10,etc.),including iron chelating agents,antioxidants,GPX4 activators,etc.,to provide new ideas for the clinical prevention and treatment of AKI-CKD transformation.

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备注/Memo

备注/Memo:
国家重点研发计划项目(2023YFC3503502)
更新日期/Last Update: 2026-07-10