[1]黄廷钦,张滨铄,闫先侠,等.磷酸甘油酸激酶 1、微小RNA138-5p、微小RNA-195在侵袭性垂体腺瘤组织中的表达及临床意义[J].陕西医学杂志,2026,(7):964-969.[doi:DOI:10.3969/j.issn.1000-7377.2026.07.016]
　HUANG Tingqin,ZHANG Binshuo,YAN Xianxia,et al.Phosphoglycerate kinase 1,miR-138-5p,and miR-195 expressionin invasive pituitary adenoma tissues and their clinical significance[J].,2026,(7):964-969.[doi:DOI:10.3969/j.issn.1000-7377.2026.07.016]
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磷酸甘油酸激酶 1、微小RNA138-5p、微小RNA-195在侵袭性垂体腺瘤组织中的表达及临床意义

《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
期数:
2026年7期
页码:
964-969
栏目:
临床检验
出版日期:
2026-07-05

文章信息/Info

Title:
Phosphoglycerate kinase 1,miR-138-5p,and miR-195 expressionin invasive pituitary adenoma tissues and their clinical significance
作者:
黄廷钦1; 张滨铄2; 闫先侠1; 董全1; 张明1; 刘重霄1; 郭振宇1
（1.西安交通大学第二附属医院，陕西 西安 710004；2.西安交通大学医学部，陕西 西安 710061）
Author(s):
HUANG Tingqin1; ZHANG Binshuo2; YAN Xianxia1; DONG Quan1; ZHANG Ming1; LIU Chongxiao1; GUO Zhenyu1
（1.The Second Affiliated Hospital of Xi ’an Jiaotong University,Xi’ an 710004，China;2.Xi’an Jiaotong University Health Science Center,Xi’an 710061,China）
关键词:
垂体瘤; 侵袭性; 磷酸甘油酸激酶1; 微小-138-5p; 微小-195; 组织表达
Keywords:
Pituitary tumor; Invasive; Phosphoglycerate kinase 1; miR-138-5p; miR-195; Organizational expression
分类号:
R 739.4
DOI:
DOI:10.3969/j.issn.1000-7377.2026.07.016
文献标志码:
A
摘要:
目的：探究磷酸甘油酸激酶1（PGK1）、微小RNA138-5p（miR-138-5p）、微小RNA-195（ miR-195）在侵袭性垂体腺瘤（IPT）组织中的表达水平及其与临床特征和预后的相关性。方法：收集168例垂体腺瘤患者为研究对象，并将其分为非IPT组（85例）和IPT组（83例）。比较两组瘤体组织中PGK1、miR-138-5p、miR-195表达水平及其与临床特征、侵袭性积分和术后复发情况的相关性。结果：IPT组瘤体组织中PGK1表达水平高于非IPT组，miR-138-5p、miR-195水平低于非IPT组（均P<0.01）。1 cm≤直径＜4 cm患者瘤体组织中PGK1表达水平高于直径＜1 cm患者，miR-138-5p、miR-195水平低于瘤体直径＜1 cm患者，≥4 cm患者瘤体组织PGK1表达水平高于1 cm≤直径＜4 cm患者，miR-138-5p、miR-195水平低于1 cm≤直径＜4 cm患者（均P<0.05）；功能性垂体瘤和Knosp分级Ⅳ级患者PGK1表达水平高于无功能性垂体瘤和Knosp分级Ⅲ级患者，miR-138-5p、miR-195水平低于无功能性垂体瘤和Knosp分级Ⅲ级患者瘤体组织（均P<0.05）。瘤体组织中PGK1水平与IPT患者侵袭性积分呈正相关，与miR-138-5p、miR-195表达水平呈负相关（r=0.833、-0.499、-0.614，均P＜0.001）；miR-138-5p、miR-195水平与侵袭性积分呈负相关（r=-0.690、-0.319，均P＜0.001），miR-138-5p与miR-195水平呈正相关（r=0.508，P＜0.001）。PGK1高表达组、miR-138-5p低表达组和miR-195低表达组的复发率均高于PGK1低表达组、miR-138-5p高表达组和miR-195高表达组（均P<0.05）。结论：IPT患者瘤体组织中PGK1表达上调，miR-138-5p、miR-195表达下调，其表达与患者肿瘤大小、病理类型、侵袭情况及术后复发情况密切相关。
Abstract:
Objective:To investigate the expression levels of phosphoglycerate kinase 1 (PGK1),microRNA-138-5p (miR-138-5p),and miR-195 in the tissues of invasive pituitary adenoma (IPT) and their correlations with the clinical characteristics and prognosis of patients.Methods：168 patients with pituitary adenomas were selected as the research subjects and were divided into the non-IPT group (85 cases) and the IPT group (83 cases).The expression levels of PGK1,miR-138-5p,and miR-195 in the tumor tissues of the two groups were compared.The correlations between the expression levels of each indicator and clinical characteristics,invasiveness score,and postoperative recurrence were analyzed.Results:The expression level of PGK1 in the tumor tissues of patients in the IPT group was higher than that in the non-IPT group,while the expression levels of miR-138-5p and miR-195 were lower than those in the non-IPT group (all P<0.01).The expression level of PGK1 in the tumor tissues of patients with a diameter ranging from 1 to 3.99 cm was higher than that of patients with a diameter less than 1 cm.The expression levels of miR-138-5p and miR-195 were lower in the tumor tissues of patients with a tumor diameter less than 1 cm compared to those of patients with a diameter ranging from 1 to 3.99 cm (all P<0.05).The expression level of PGK1 in the tumor tissues of patients with a diameter of 4 cm or more was higher than that of patients with a diameter ranging from 1 to 3.99 cm,the expression levels of miR-138-5p and miR-195 were lower in the tumor tissues of patients with a diameter of 4 cm or more compared to those of patients with a diameter ranging from 1 to 3.99 cm (all P<0.05).The expression levels of PGK1 in the tumor tissues of patients with functional pituitary adenomas and Knosp grade Ⅳ were higher than those of patients without functional pituitary adenomas and Knosp grade Ⅲ,while the expression levels of miR-138-5p and miR-195 were lower in the tumor tissues of patients with functional pituitary adenomas and Knosp grade Ⅳ compared to those of patients without functional pituitary adenomas and Knosp grade Ⅲ (all P<0.05).The level of PGK1 in tumor tissues was positively correlated with the invasive score of IPT patients,and negatively correlated with the expression levels of miR-138-5p and miR-195 (r=0.833,-0.499,-0.614,all P<0.001);the levels of miR-138-5p and miR-195 were negatively correlated with the invasive score (r=-0.690,-0.319,all P<0.001),and the level of miR-138-5p was positively correlated with the level of miR-195 (r=0.508,P<0.001).The recurrence rates of the high-expression group of PGK1,the low-expression group of miR-138-5p,and the low-expression group of miR-195 were all higher than those of the low-expression group of PGK1,the high-expression group of miR-138-5p,and the high-expression group of miR-195 (Logrank χ2= 6.335,20.839,12.838,all P<0.05).Conclusion:In the tumor tissues of IPT patients,the expression of PGK1 is upregulated,while the expressions of miR-138-5p and miR-195 are downregulated.Their expressions are closely related to the size of the tumor,pathological type,invasion status,and postoperative recurrence of the patients.

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备注/Memo

备注/Memo:
陕西省重点研发计划项目(2022SF-396)
更新日期/Last Update: 2026-07-10