[1]罗孜贤,田浩.血清溶质载体家族7成员11、沉默信息调节蛋白1、酰基辅酶A合成酶长链家族成员4与急性脑梗死缺血再灌注损伤及预后的相关性[J].陕西医学杂志,2026,(7):935-939.[doi:DOI:10.3969/j.issn.1000-7377.2026.07.011]
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血清溶质载体家族7成员11、沉默信息调节蛋白1、酰基辅酶A合成酶长链家族成员4与急性脑梗死缺血再灌注损伤及预后的相关性

《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
期数:
2026年7期
页码:
935-939
栏目:
临床研究
出版日期:
2026-07-05

文章信息/Info

作者:
罗孜贤1; 田浩2
（1.武汉科技大学附属紫荆医院 武汉紫荆医院神经内科，湖北 武汉 430062；2.湖北省第三人民医院神经内科，湖北 武汉 430033）
关键词:
溶质载体家族7成员11; 沉默信息调节蛋白1; 酰基辅酶A合成酶长链家族成员4; 急性脑梗死; 缺血再灌注损伤; 预后
分类号:
R 743.3
DOI:
DOI:10.3969/j.issn.1000-7377.2026.07.011
文献标志码:
A
摘要:
目的：探讨血清溶质载体家族7成员11（SLC7A11）、沉默信息调节蛋白1（SIRT1）、酰基辅酶A合成酶长链家族成员4（ACSL4）与急性脑梗死缺血再灌注损伤及预后的关系。方法：选取急性脑梗死患者218例，治疗后发生再灌注损伤患者42例（缺血再灌注损伤组），未发生再灌注损伤患者176（非缺血再灌注损伤组）。其中缺血再灌注损伤组中预后不良12例，预后良好30例。比较缺血再灌注损伤组和非缺血再灌注损伤组血清SLC7A11、SIRT1、ACSL4差异，以及缺血再灌注损伤组不同预后患者间血清SLC7A11、SIRT1、ACSL4差异。结果：缺血再灌注损伤组患者血清SLC7A11和SIRT1分别为（14.43±3.43）ng/ml和（4.65±1.02）g/L，明显低于非缺血再灌注损伤组（均P＜0.05），而ACSL4为（47.28±8.21）ng/ml，明显高于非缺血再灌注损伤组（P＜0.05）。缺血再灌注损伤组预后不良患者血清SLC7A11和SIRT1分别为（13.15±2.24）ng/ml和（4.14±0.98）g/L，明显低于预后良好患者（均P＜0.05），而ACSL4为（50.32±5.04）ng/ml，明显高于预后良好患者（P＜0.05）。血清SLC7A11、SIRT1、ACSL4预测缺血再灌注损伤的ROC曲线下面积分别为0.666（95%CI：0.584～0.748）、0.840（95%CI：0.778～0.901）和0.758（95%CI：0.677～0.839）(均P＜0.05）。血清SLC7A11、SIRT1、ACSL4预测缺血再灌注损伤患者预后不良的ROC曲线下面积分别为0.833（95%CI：0.695～0.971）、0.781（95%CI：0.600～0.961）和0.897（95%CI：0.802～0.993）(均P＜0.05）。结论：急性脑梗死缺血再灌注损伤患者血清SLC7A11和SIRT1水平降低，而ACSL4水平升高，三者在预测急性脑梗死缺血再灌注损伤及缺血再灌注损伤后预后方面均有一定应用价值。

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备注/Memo

备注/Memo:
湖北省自然科学基金资助项目（2022CFB870，2022CFB434）
更新日期/Last Update: 2026-07-10