[1]宁珊珊,任海霞,刘倩,等.增龄性心房颤动患者认知衰弱现状及其影响因素分析[J].陕西医学杂志,2026,(7):930-934.[doi:DOI:10.3969/j.issn.1000-7377.2026.07.010]
　NING Shanshan,REN Haixia,LIU Qian,et al.Analysis of the current status of cognitive frailtyin patients with senile atrial fibrillation and its influencing factors[J].,2026,(7):930-934.[doi:DOI:10.3969/j.issn.1000-7377.2026.07.010]
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增龄性心房颤动患者认知衰弱现状及其影响因素分析

《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
期数:
2026年7期
页码:
930-934
栏目:
临床研究
出版日期:
2026-07-05

文章信息/Info

Title:
Analysis of the current status of cognitive frailtyin patients with senile atrial fibrillation and its influencing factors
作者:
宁珊珊; 任海霞; 刘倩; 李婧; 李晓莉; 王蓉
（西安交通大学第二附属医院，陕西 西安710004）
Author(s):
NING Shanshan; REN Haixia; LIU Qian; LI Jing; LI Xiaoli; WANG Rong
（The Second Affiliated Hospital of Xi’an Jiaotong University,Xi’an 710004，China）
关键词:
心房颤动; 增龄性; 认知衰弱; 躯体衰弱; 睡眠障碍; 影响因素
Keywords:
Atrial fibrillation; Aging; Cognitive frailty; Physical weakness; Sleep disorder; Influencing factors
分类号:
R 541.7
DOI:
DOI:10.3969/j.issn.1000-7377.2026.07.010
文献标志码:
A
摘要:
目的：探查增龄性心房颤动（AF）患者认知衰弱患病情况，分析影响该群体认知衰弱患病的影响因素。方法：选择便利抽样法收集400例增龄性AF患者为研究对象。依据2013年国际共识小组提出的认知衰弱定义标准筛查研究对象认知衰弱患病情况。多因素Logisitic回归分析法分析患者认知衰弱患病的影响因素。结果：增龄性AF患者认知衰弱患病率为17.75%。不同年龄、家庭人均月收入、居住状态、睡眠障碍、营养状况、抑郁、规律运动、生活自理能力和左室射血分数（LVEF）水平的患者认知衰弱发生率间比较，差异具有统计学意义（均P＜0.05）。多因素Logistic回归分析显示，年龄增加、居住状态、睡眠障碍、营养状况、抑郁、生活自理能力、LVEF水平均是增龄性AF患者认知衰弱发生的独立危险因素，规律运动均是增龄性AF患者认知衰弱发生的保护因素（均P＜0.05）。结论：受年龄、居住状态、睡眠、营养、抑郁情绪、运动、生活自理能力及心室功能多种因素影响，导致增龄性AF患者存在一定认知衰弱患病风险。
Abstract:
Objective:To investigate the prevalence of cognitive frailty in elderly patients with atrial fibrillation (AF),and to analyze the influencing factors of cognitive frailty in this group.Methods：A convenience sampling method was used to select 400 patients with age-related AF as the research subjects.The prevalence of cognitive frailty among the research subjects was screened according to the definition standard of cognitive frailty proposed by the International Consensus Group in 2013.Multivariate Logistic regression analysis was used to analyze the influencing factors of cognitive frailty in the patients.Results:The prevalence of cognitive frailty in patients with senile AF was 17.75%.There were statistically significant differences in the incidence of cognitive frailty among patients with different ages,average monthly household income,living conditions,sleep disorders,nutritional status,depression,regular exercise,self-care ability and left ventricular ejection fraction (LVEF) levels (all P<0.05).Multivariate Logistic regression analysis revealed that increasing age,living condition,sleep disorder,nutritional status,depression,self-care ability,LVEF level were independent risk factors for cognitive frailty in patients with senile AF,while regular exercise was a protective factor for cognitive frailty in these patients (all P<0.05).Conclusion:Aging,living conditions,sleep,nutrition,depression,exercise,self-care ability,and ventricular function are all factors that affect the risk of cognitive frailty in patients with age-related atrial fibrillation.

参考文献/References:

[1]KARNIK A A,SACZYNSKI J S,CHUNG J J,et al.Cognitive impairment,age,quality of life,and treatment strategy for atrial fibrillation in older adults：The SAGE-AF study[J].J Am Geriatr Soc,2022,70(10)：2818-2826.
[2]BIZHANOV K A,ABZALIYEV K B,BAIMBETOV A K,et al.Atrial fibrillation：Epidemiology,pathophysiology,and clinical complications (literature review)[J].J Cardiovasc Electrophysiol,2023,34(1)：153-165.
[3]窦毓,熊亚晴.老年人心房颤动与衰弱相关研究进展[J].实用老年医学,2022,36(7)：650-654.
[4]HARRISON S L,JOHNSEN S P,LIP G Y H.The impact of frailty on the management of atrial fibrillation[J].Aging (Albany NY),2023,15(14)：6622-6624.
[5]KELAIDITI E,CESARI M,CANEVELLI M,et al.Cognitive frailty：Rational and definition from an (I.A.N.A./I.A.G.G.) international consensus group[J].J Nutr Health Aging,2013,17(9)：726-734.
[6]鲍晓敏,史晓,沈雁.从“肾”论治老年衰弱综合征[J].陕西中医,2019,40(8):1098-1100.
[7]WANG W,LESSARD D,KIEFE C I,et al.Differential effect of anticoagulation according to cognitive function and frailty in older patients with atrial fibrillation[J].J Am Geriatr Soc,2023,71(2)：394-403.
[8]张冰倩,何艳.抗凝治疗与导管消融在预防心房颤动患者痴呆中的策略与进展[J].陕西医学杂志,2025,54(10)：1428-1431.
[9]邢雨涵,张月,姚志萍,等.老年房颤患者认知衰弱预测模型的构建与验证[J].军事护理,2024,41(7)：38-42.
[10]中华医学会,中华医学会杂志社,中华医学会全科医学分会,等.心房颤动基层诊疗指南(实践版·2019)[J].中华全科医师杂志,2020,19(6)：474-481.
[11]卫尹,曹艳佩,杨晓莉,等.老年住院患者衰弱风险筛查工具的汉化及信效度研究[J].中国实用护理杂志,2018,34(20)：1526-1530.
[12]高中宝,王炜,尚延昌,等.蒙特利尔认知量表中文版诊断老年轻度认知功能损害的应用研究[J].中华保健医学杂志,2011,13(3)：225-227.
[13]SOLDATOS C R,DIKEOS D G,PAPARRIGOPOULOS T J.The diagnostic validity of the athens insomnia scale[J].J Psychosom Res,2003,55(3)：263-267.
[14]KALUZNIAK-SZYMANOWSKA A,DESKUR-SMIELECKA E,KRZYMINSKA-SIEMASZKO R,et al.Diagnostic performance of mini nutritional assessment-short form against the global leadership initiative on malnutrition criteria[J].Sci Rep,2025,15(1)：45621-45647.
[15]唐丹.简版老年抑郁量表(GDS-15)在中国老年人中的使用[J].中国临床心理学杂志,2013,21(3)：402-405.
[16]纪婕.康复病房分级管理中Barthel指数量表的应用[J].中医药管理杂志,2020,28(10)：155-156.
[17]中华医学会心血管病学分会，中国医师协会心血管内科医师分会，中国医师协会心力衰竭专业委员会,等.中国心力衰竭诊断和治疗指南2024[J].中华心血管病杂志,2024,52(3)：235-275.
[18]何海龙,谢连娣,王雅婧.心房颤动脉象研究进展[J].陕西中医,2023,44(11)：1650-1652.
[19]XIE B,MA C,CHEN Y,et al.Prevalence and risk factors of the co-occurrence of physical frailty and cognitive impairment in Chinese community-dwelling older adults[J].Health Soc Care Community,2021,29(1)：294-303.
[20]王怡欣,傅荣,张建薇,等.社区老年人认知衰弱危险因素的meta分析[J].重庆医学,2022,51(19)：3364-3369.
[21]LILAMAND M,SAINTOUT M,VIGAN M,et al.Quality of life,physical performance and nutritional status in older patients hospitalized in a cardiology department[J].J Geriatr Cardiol,2020,17(7)：410-416.
[22]王慧,吴玉霞,董苏云,等.老年癌症患者认知衰弱现状及影响因素分析[J].护士进修杂志,2025,40(23)：2472-2478.
[23]LUCEY B P.Sleep alterations and cognitive decline[J].Semin Neurol,2025,45(3)：333-347.
[24]JIANG R,NOBEL S,ROSENBLATT M,et al.The brain structure,inflammatory,and genetic mechanisms mediate the association between physical frailty and depression[J].Nat Commun,2024,15(1)：4411-4421.
[25]BAEK J E,HYEOMN S J,KIM M,et al.Effects of dual-task resistance exercise on cognition,mood,depression,functional fitness,and activities of daily living in older adults with cognitive impairment：A single-blinded,randomized controlled trial[J].B M C Geriatr,2024,24(1)：369-380.

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备注/Memo

备注/Memo:
国家自然科学基金资助项目（82200358）
更新日期/Last Update: 2026-07-10