[1]陈传立,王 建.低温治疗缺血性脑卒中的神经保护机制研究进展[J].陕西医学杂志,2026,(5):697-703.[doi:DOI:10.3969/j.issn.1000-7377.2026.05.022]
　CHEN Chuanli,WANG Jian.Research progress on the neuroprotective mechanisms of hypothermia therapy for ischemic stroke[J].,2026,(5):697-703.[doi:DOI:10.3969/j.issn.1000-7377.2026.05.022]
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低温治疗缺血性脑卒中的神经保护机制研究进展

《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
期数:
2026年5期
页码:
697-703
栏目:
综述
出版日期:
2026-05-05

文章信息/Info

Title:
Research progress on the neuroprotective mechanisms of hypothermia therapy for ischemic stroke
作者:
陈传立1; 王 建2
（1.川北医学院，四川 南充 637000；2.雅安市人民医院，四川 雅安 625000）
Author(s):
CHEN Chuanli1; WANG Jian2
(1.North Sichuan Medical College,Nanchong 637000,China;2.Ya’an People’s Hospital,Ya’an 625000,China)
关键词:
缺血性脑卒中; 低温治疗; 神经保护机制; 氧化应激; 炎症反应; 细胞凋亡; 并发症
Keywords:
Ischemic stroke; Hypothermia therapy; Neuroprotective mechanism; Oxidative stress; Inflammatory response; Apoptosis; Complications
分类号:
R743.3
DOI:
DOI:10.3969/j.issn.1000-7377.2026.05.022
文献标志码:
A
摘要:
缺血性脑卒中是全球致死、致残率较高的神经系统疾病，其病理生理过程复杂，涉及兴奋性毒性、氧化应激、炎症反应、细胞凋亡等多重损伤机制，临床缺乏特效神经保护药物。低温治疗作为一种具有潜在神经保护作用的物理干预手段，已在动物实验和部分临床研究中证实可减轻缺血性脑损伤，改善神经功能预后。本文从抑制兴奋性毒性、减轻氧化应激损伤、调控炎症反应、抑制细胞凋亡、保护血脑屏障、调节自噬功能等方面，系统综述低温治疗缺血性脑卒中的神经保护机制研究进展，对比全身低温与局部低温治疗的优势与局限性，明确低温治疗的启动、维持及复温时间节点，总结低温治疗常见并发症及处理方式，同时剖析当前临床应用中的争议与挑战，并对未来研究方向进行展望，为低温治疗缺血性脑卒中的临床转化与优化提供理论依据。
Abstract:
Ischemic stroke is a neurological disease with high mortality and disability rates worldwide.Its pathophysiological process is complex,involving multiple injury mechanisms such as excitotoxicity,oxidative stress,inflammatory response and apoptosis,and there is a lack of specific neuroprotective drugs in clinical practice.As a physical intervention with potential neuroprotective effects,hypothermia therapy has been confirmed in animal experiments and some clinical studies to alleviate ischemic brain injury and improve neurological prognosis.This article systematically reviews the research progress on the neuroprotective mechanisms of hypothermia therapy for ischemic stroke,including inhibiting excitotoxicity,reducing oxidative stress injury,regulating inflammatory response,inhibiting apoptosis,protecting blood-brain barrier,and regulating autophagic function.It compares the advantages and limitations of systemic hypothermia and local hypothermia therapy,clarifies the time nodes of initiation,maintenance and rewarming of hypothermia therapy,summarizes the common complications of hypothermia therapy and their management methods.Meanwhile,it analyzes the controversies and challenges in current clinical application and prospects the future research directions,so as to provide a theoretical basis for the clinical transformation and optimization of hypothermia therapy for ischemic stroke.

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备注/Memo

备注/Memo:
国家自然科学基金资助项目（81900276）
更新日期/Last Update: 2026-05-05