[1]陈 锦,李 梦.血清sB7-H3、LTB4对急性牙髓炎患儿根管治疗期间急症发生的预测价值[J].陕西医学杂志,2026,(5):628-632,638.[doi:DOI:10.3969/j.issn.1000-7377.2026.05.009]
　CHEN Jin,LI Meng.Predictive value of serum sB7-H3 and LTB4 for endodontic interappointment emergencies in children with acute pulpitis[J].,2026,(5):628-632,638.[doi:DOI:10.3969/j.issn.1000-7377.2026.05.009]
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血清sB7-H3、LTB4对急性牙髓炎患儿根管治疗期间急症发生的预测价值

《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
期数:
2026年5期
页码:
628-632,638
栏目:
临床研究
出版日期:
2026-05-05

文章信息/Info

Title:
Predictive value of serum sB7-H3 and LTB4 for endodontic interappointment emergencies in children with acute pulpitis
作者:
陈 锦; 李 梦
（荆门市人民医院 荆楚理工学院附属荆门市人民医院口腔科，湖北 荆门 448000）
Author(s):
CHEN Jin; LI Meng
（Department of Stomatology,Jingmen People’s Hospital,Jingmen 448000,China）
关键词:
急性牙髓炎; 可溶性B7同源体3; 白三烯B4; 根管治疗期间急症; 预测价值
Keywords:
Acute pulpitis; Soluble B7-homolog 3; Leukotriene B4; Endodontic interappointment emergencies; Predictive value
分类号:
R781.31
DOI:
DOI:10.3969/j.issn.1000-7377.2026.05.009
文献标志码:
A
摘要:
目的：探讨可溶性B7同源体3（sB7-H3）、白三烯B4（LTB4）水平在急性牙髓炎患儿血清中的变化，以及二者对根管治疗期间急症（EIAE）发生的预测价值。方法：选取急性牙髓炎患儿100例作为急性牙髓炎组，另选取同期体检的健康儿童96例作为健康组。行根管治疗后，根据视觉模拟评分法（VAS）评估患儿疼痛情况；根据EIAE发生情况将患儿分为无EIAE组（76例）和EIAE组（24例）。使用酶联免疫试剂盒检测血清sB7-H3、LTB4水平。采用Spearman法分析血清sB7-H3、LTB4水平与患儿VAS评分的相关性。采用受试者工作特征（ROC）曲线分析血清sB7-H3、LTB4对急性牙髓炎患儿EIAE发生的预测价值。采用决策曲线分析（DCA）评估血清sB7-H3、LTB4联合预测急性牙髓炎患儿EIAE发生风险的临床实用性。结果：急性牙髓炎组患儿血清sB7-H3、LTB4水平高于健康组（均P<0.05）。EIAE组患儿根尖X线有阴影比例、炎症消退时间及血清sB7-H3、LTB4水平高于无EIAE组（均P<0.05）。与血清sB7-H3、LTB4低水平比较，高水平患儿VAS评分较高（均P<0.05）。血清sB7-H3、LTB4水平与VAS评分呈正相关（均P<0.05）。血清sB7-H3、LTB4单独预测急性牙髓炎患儿EIAE发生的曲线下面积（AUC）分别为0.805、0.842，二者联合预测急性牙髓炎患儿EIAE发生的AUC为0.915，高于单独预测（均P<0.05）。当高风险阈值为0.08~0.97时，血清sB7-H3联合LTB4预测急性牙髓炎患儿EIAE发生风险的净获益率优于两者单独预测。结论：急性牙髓炎患儿血清sB7-H3、LTB4水平升高，与VAS评分有关，二者联合对患儿EIAE发生的预测价值较高。
Abstract:
Objective:To investigate the changes in serum levels of soluble B7-homolog 3 (sB7-H3) and leukotriene B4 (LTB4) in children with acute pulpitis,and to evaluate their predictive value for endodontic interappointment emergencies (EIAE).Methods：A total of 100 children with acute pulpitis were enrolled as the acute pulpitis group,and 96 healthy children were selected as the healthy control group.After root canal therapy,pain was evaluated using the Visual Analogue Scale (VAS).According to the occurrence of EIAE,the children were divided into a non-EIAE group (76 cases) and an EIAE group (24 cases).Serum levels of sB7-H3 and LTB4 were detected by enzyme-linked immunosorbent assay kits.Spearman correlation analysis was used to assess the correlation between serum sB7-H3 and LTB4 levels and VAS scores.ROC curve analysis was performed to evaluate the predictive value of serum sB7-H3 and LTB4 for EIAE in children with acute pulpitis.DCA was applied to assess the clinical utility of the combined detection of serum sB7-H3 and LTB4 in predicting the risk of EIAE.Results:Serum levels of sB7-H3 and LTB4 in the acute pulpitis group were significantly higher than those in the healthy control group (all P<0.05).The proportion of apical radiolucency on X-ray,duration of inflammation regression,and serum levels of sB7-H3 and LTB4 in the EIAE group were significantly higher than those in the non-EIAE group (all P<0.05).Children with high serum levels of sB7-H3 and LTB4 had higher VAS scores than those with low levels (all P<0.05).Serum sB7-H3 and LTB4 levels were positively correlated with VAS scores (all P<0.05).The AUC of serum sB7-H3 and LTB4 alone for predicting EIAE was 0.805 and 0.842,respectively,and the combined AUC was 0.915,which was significantly higher than that of single detection (all P<0.05).When the high-risk threshold ranged from 0.08 to 0.97,the net benefit rate of the combined prediction of EIAE risk by serum sB7-H3 and LTB4 was superior to that of single prediction.Conclusion:Serum levels of sB7-H3 and LTB4 are elevated in children with acute pulpitis and are associated with VAS scores.The combination of sB7-H3 and LTB4 shows high predictive value for EIAE in these children.

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备注/Memo

备注/Memo:
湖北省卫生健康委员会卫生健康科研立项项目（WJ2021F080）
更新日期/Last Update: 2026-05-05