[1]刘园,郝杰,方奎,等.中国中老年人C反应蛋白甘油三酯葡萄糖指数与心血管疾病风险研究[J].陕西医学杂志,2026,(4):480-484.[doi:DOI:10.3969/j.issn.1000-7377.2026.04.008]
　LIU Yuan,HAO Jie,FANG Kui,et al.Creactive protein triglyceride glucose index and cardiovascular disease risk in Chinese miD-Dleaged and elderly people[J].,2026,(4):480-484.[doi:DOI:10.3969/j.issn.1000-7377.2026.04.008]
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中国中老年人C反应蛋白甘油三酯葡萄糖指数与心血管疾病风险研究

《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
期数:
2026年4期
页码:
480-484
栏目:
临床研究
出版日期:
2026-04-05

文章信息/Info

Title:
Creactive protein triglyceride glucose index and cardiovascular disease risk in Chinese miD-Dleaged and elderly people
作者:
刘园1; 郝杰2; 方奎1; 2; 伊朗1
(1.中国医科大学附属第一医院，辽宁 沈阳 110001；2.武汉大学护理学院，湖北 武汉 430071)
Author(s):
LIU Yuan1; HAO Jie2; FANG Kui1; 2; YI Lang1
（1.The First Hospital Affiliated to China Medical University,Shenyang 110001，China；2.School of Nursing,Wuhan University,Wuhan 430071，China）
关键词:
C反应蛋白甘油三酯葡萄糖指数; 心血管疾病; 甘油三酯葡萄糖指数; C反应蛋白; 队列研究; 中老年人
Keywords:
Creactive protein triglyceride glucose index; Cardiovascular disease; Triglycerideglucose index; Creactive protein; Cohort study; MiD-Dleaged and elderly people
分类号:
R 543
DOI:
DOI:10.3969/j.issn.1000-7377.2026.04.008
文献标志码:
A
摘要:
目的：研究C反应蛋白甘油三酯葡萄糖指数（CTI）与中国中老年人心血管疾病（CVD）发病风险的关联性，以期为CVD的早期预防、精准管理提供依据。方法：采用前瞻性队列研究，以中老年人为研究对象。首先采用限制性立方样条分析CTI与中老年人CVD风险间是否存在剂量反应关系；其次以CTI四分位数进行分组，采用Cox比例风险回归模型评估不同组别中CTI水平与中老年人的CVD风险；最后绘制受试者工作特征曲线（ROC），评估CTI、C反应蛋白（CRP）及甘油三酯葡萄糖指数（TyG）对CVD发病的预测效能。结果：共纳入7606例研究对象，在9年随访期间，共有1447例（19.02%）研究对象发生了CVD。CTI水平与中老年人CVD风险间存在剂量反应关系。多元Cox比例风险回归模型显示：多因素调整后，高水平的CTI会增加中老年人CVD风险。与Quartile 1组比较，Quartile 3组和Quartile 4组发生CVD风险分别增加了30%（HR=1.30，1.12~1.52)和42%（HR=1.42,1.21~1.67)。ROC曲线表明CTI在预测CVD风险方面优于CRP和TyG指标。结论：高水平的CTI会增加中老年人CVD风险。
Abstract:
Objective:To investigate the association between Creactive proteintriglyceride glucose index (CTI) and the risk of cardiovascular disease (CVD) in miD-Dleaged and elderly Chinese people,with a view to providing a basis for early prevention and precise management of CVD.Methods：A prospective cohort study was conducted with miD-Dleaged and elderly individuals as the study population.First,a restricted cubic spline analysis was used to determine whether there was a doseresponse relationship between CTI and CVD risk in miD-Dleaged and elderly individuals.Second,participants were grouped based on CTI quartiles,and a Cox proportional hazards regression model was used to assess the association between CTI levels and CVD risk in different groups.Finally,receiver operating characteristic (ROC) curves were plotted to assess the predictive performance of CTI,Creactive protein (CRP),and triglycerideglucose index (TyG) for CVD incidence.Results:A total of 7606 study participants were included.During the 9year followup period,1447 (19.02%) participants developed CVD.There was a doseresponse relationship between CTI levels and CVD risk in miD-Dleaged and older adults.Multivariate Cox proportional hazards regression models showed that,after adjusting for multiple factors,high CTI levels increased the risk of CVD in miD-Dleaged and older adults.Compared with the quartile 1 group,the quartile 3 and quartile 4 groups had a 30% (HR=1.30,1.12~1.52) and 42% (HR=1.42,1.21~1.67) increased risk of CVD,respectively.The ROC curve indicated that CTI was superior to CRP and TyG in predicting CVD risk.Conclusion:High levels of CTI increase the risk of CVD in miD-Dleaged and older adults.

参考文献/References:

[1]HU S S.Report on cardiovascular health and diseases in China 2021：An updated summary[J].J Geriatr Cardiol,2023,20(6)：399-430.
[2]姜红,苏梓涵,何丹丹,等.健康生活方式与心血管代谢性疾病关联研究[J].陕西医学杂志,2025,54(7)：919-924.
[3]ARNOLD N,LECHNER K,WALDEYER C,et al.Inflammation and cardiovascular disease：The future[J].Eur Cardiol,2021,16：e20.
[4]李震,晋群.炎症在冠心病发生发展中的作用及抗炎治疗研究进展[J].陕西医学杂志,2025,54(7)：1001-1004，1009.
[5]HUYNH X N,梁硕,孟毅,等.益气活血清热解毒方治疗动脉粥样硬化临床研究[J].陕西中医,2023,44(6)：746-750.
[6]ROLVER M G,EMANUELSSON F,NORDESTGARRD B G,et al.Contributions of elevated CRP,hyperglycaemia,and type 2 diabetes to cardiovascular risk in the general population：Observational and mendelian randomization studies[J].Cardiovasc Diabetol,2024,23(1)：165.
[7]TANG S,WANG H,LI K,et al.C-reactive protein-triglyceride glucose index predicts stroke incidence in a hypertensive population：A national cohort study[J].Diabetol Metab Syndr,2024,16(1)：277.
[8]XU M,ZHANG L,XU D,et al.Usefulness of C-reactive protein-triglyceride glucose index in detecting prevalent coronary heart disease：Findings from the National Health and Nutrition Examination Survey 1999-2018[J].Front Cardiovasc Med,2024,11：1485538.
[9]ZHAO D F.Value of C-reactive protein-triglyceride glucose index in predicting cancer mortality in the general population：Results from National Health and Nutrition Examination Survey[J].Nutr Cancer,2023,75(10)：1934-1944.
[10]ZGAO Y,HU Y,SMITH J P,et al.Cohort profile：The China Health and Retirement Longitudinal Study (CHARLS)[J].Int J Epidemiol,2014,43(1)：61-68.
[11]RUAN G T,XIE H L,ZHANG H Y,et al.A novel inflammation and insulin resistance related indicator to predict the survival of patients with cancer[J].Front Endocrinol (Lausanne),2022,13：905266.
[12]GAO K,CAO L F,MA W Z,et al.Association between sarcopenia and cardiovascular disease among middle-aged and older adults：Findings from the China health and retirement longitudinal study[J].E Clinical Medicine,2022,44：101264.
[13]DENEGRI A,BORIANI G.High sensitivity C-reactive Protein (hsCRP) and its implications in cardiovascular outcomes[J].Curr Pharm Des,2021,27(2)：263-275.
[14]CUI C,LIU L,QI Y,et al.Joint association of TyG index and high sensitivity C-reactive protein with cardiovascular disease：A national cohort study[J].Cardiovasc Diabetol,2024,23(1)：156.
[15]SUN Y,GUO Y,MA S,et al.Association of C-reactive protein-triglyceride glucose index with the incidence and mortality of cardiovascular disease：A retrospective cohort study[J].Cardiovasc Diabetol,2025,24(1)：313.
[16]ZAHARISHAM S Y,HANIF E,THAMBIAN S C,et al.High sensitivity C-reactive protein (hsCRP)：Its relationship with metabolic syndrome and Framingham Risk Score[J].Malays J Pathol,2021,43(1)：33-40.
[17]TANDON P,ABRAMS N D,CARRICK D M,et al.Metabolic regulation of inflammation and its resolution：Current status,clinical needs,challenges,and opportunities[J].J Immunol,2021,207(11)：2625-2630.
[18]GRUNDY S M,STONE N J,BAILEY A L,et al.2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA guideline on the management of blood cholesterol：A Report of the American College of Cardiology/American Heart Association Task Force on clinical practice guidelines[J].Circulation,2019,139(25)：e1082-e1143.
[19]YANG T,LI G,WANG C,et al.Insulin resistance and coronary inflammation in patients with coronary artery disease：A cross-sectional study[J].Cardiovasc Diabetol,2024,23(1)：79.
[20]JIN A,WANG S,LI J,et al.Mediation of systemic inflammation on insulin resistance and prognosis of nondiabetic patients with ischemic stroke[J].Stroke,2023,54(3)：759-769.
[21]LIBBY P.Inflammation in atherosclerosis[J].Nature,2002,420(6917)：868-874.
[22]PUSCHEL G P,KLAUDER J,HENKEL J.Macrophages,low-grade inflammation,insulin resistance and hyperinsulinemia：A mutual ambiguous relationship in the development of metabolic diseases[J].J Clin Med,2022,11(15):1252-1258.
[23]DEVARAJ S,YUN J M,ADAMSON G,et al.C-reactive protein impairs the endothelial glycocalyx resulting in endothelial dysfunction[J].Cardiovasc Res,2009,84(3)：479-484.
[24]WAN B,WANG S,HU S,et al.The comprehensive effects of high-sensitivity C-reactive protein and triglyceride glucose index on cardiometabolic multimorbidity[J].Front Endocrinol (Lausanne),2025,16：1511319.
[25]HUO G,ZHENGJ,CAO J,et al.Association between triglyceride-glucose index and carotid plaque stability in different glycemic status：A single-center retrospective study[J].J Am Heart Assoc,2025,14(3)：e037970.

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备注/Memo

备注/Memo:
国家自然青年科学基金资助项目(82103450)
更新日期/Last Update: 2026-04-05