[1]李秋雨,陈静静,王鑫,等.超声权重评分联合血清Tg-Ab、TPO-Ab水平在甲状腺结节良恶性鉴别中的价值研究[J].陕西医学杂志,2026,(3):334-338.[doi:DOI:10.3969/j.issn.1000-7377.2026.03.007]
　LI Qiuyu,CHEN Jingjing,WANG Xin,et al.Value of ultrasound weight score combined with serum Tg-Ab and TPO-Ab levels in differentiation of benign and malignant thyroid nodules[J].,2026,(3):334-338.[doi:DOI:10.3969/j.issn.1000-7377.2026.03.007]
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超声权重评分联合血清Tg-Ab、TPO-Ab水平在甲状腺结节良恶性鉴别中的价值研究

《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
期数:
2026年3期
页码:
334-338
栏目:
临床研究
出版日期:
2026-03-05

文章信息/Info

Title:
Value of ultrasound weight score combined with serum Tg-Ab and TPO-Ab levels in differentiation of benign and malignant thyroid nodules
作者:
李秋雨; 陈静静; 王鑫; 郑骄阳; 芦润清; 张家齐
（海军军医大学第二附属医院健康管理中心，上海 200003）
Author(s):
LI Qiuyu; CHEN Jingjing; WANG Xin; ZHENG Jiaoyang; LU Runqing; ZHANG Jiaqi
(Health Management Center,the Second Affiliated Hospital of Naval Medical University,Shanghai 200002,China)
关键词:
甲状腺结节; 恶性; 超声权重评分; 抗甲状腺球蛋白抗体; 抗甲状腺过氧化物酶抗体; 鉴别价值
Keywords:
Thyroid nodules; Malignant; Ultrasound weight score; TG-Ab; TPO-Ab; Differential value
分类号:
R 581
DOI:
DOI:10.3969/j.issn.1000-7377.2026.03.007
文献标志码:
A
摘要:
目的：探讨超声权重评分联合血清甲状腺球蛋白抗体（Tg-Ab）、抗甲状腺过氧化物酶抗体（TPO-Ab）水平在甲状腺结节良恶性鉴别中的价值。方法：选取93例甲状腺结节患者，以病理结果分为两组，即良性组（64例）和恶性组（29例）。比较两组超声权重评分及血清Tg-Ab、TPO-Ab、甲状腺球蛋白（Tg）、促甲状腺激素（TSH）水平。分析超声权重评分联合血清Tg-Ab、TPO-Ab水平在甲状腺结节良恶性鉴别中的价值。结果：93例患者共101个甲状腺结节，良性占65.35%（66/101），恶性占34.65%（35/101）。与良性组比较，恶性组患者超声权重评分及血清Tg-Ab、TPO-Ab、Tg、TSH水平明显升高（均P＜0.05）。超声权重评分联合血清Tg-Ab、TPO-Ab水平鉴别甲状腺良恶性结节的价值明显高于三项独立检测（均P＜0.05）。结论：Tg-Ab、TPO-Ab可能参与了恶性甲状腺结节的发生、发展，且超声权重评分联合血清Tg-Ab、TPO-Ab水平对良恶性甲状腺结节具有良好的鉴别价值。
Abstract:
Objective:To investigate the value of ultrasound weight score combined with serum anti-thyroglobulin antibody (Tg-Ab) and anti-thyroid peroxidase antibody (TPO-Ab) levels in the differentiation of benign and malignant thyroid nodules.Methods：A total of 93 patients with thyroid nodules were selected and divided into two groups according to pathological results,namely benign group (n=64) and malignant group (n=29).The ultrasound weight score,and serum TG-Ab,TPO-Ab,Tg,TSH levels were compared between the two groups.The value of ultrasound weight score combined with serum Tg-Ab,TPO-Ab levels in differentiating benign and malignant thyroid nodules was analyzed.Results:There were 101 thyroid nodules in 93 patients.Benign thyroid nodules accounted for 65.35% (66/101),and malignant accounted for 34.65% (35/101).Compared with the benign group,the ultrasound weight score,serum TG-Ab,TPO-Ab,Tg and TSH levels in the malignant group were significantly higher (all P<0.05).The AUC value of ultrasound weight score combined with serum Tg-Ab and TPO-Ab levels in the differential diagnosis of benign and malignant thyroid nodules was 0.904,which was significantly higher than that of the three independent tests (all P<0.05).Conclusion:Tg-Ab and TPO-Ab may be involved in the occurrence and development of malignant thyroid nodules.Moreover,the combined use of ultrasound weight score and serum Tg-Ab and TPO-Ab levels has good differential value for benign and malignant thyroid nodules.

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备注/Memo

备注/Memo:
国家自然科学基金资助项目（81800865）；上海市自然科学基金资助项目（JCZRYB202401301）
更新日期/Last Update: 2026-03-05