[1]林 豪,郭俊.口腔癌患者血清TFF1、CYFRA21-1、uPA水平变化及检测意义[J].陕西医学杂志,2026,(2):263-267.[doi:DOI:10.3969/j.issn.1000-7377.2026.02.022]
　LIN Hao,GUO Jun.Changes and detection significance of serum TFF1,CYFRA21-1 and uPA levels in patients with oral cancer[J].,2026,(2):263-267.[doi:DOI:10.3969/j.issn.1000-7377.2026.02.022]
点击复制

口腔癌患者血清TFF1、CYFRA21-1、uPA水平变化及检测意义

《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
期数:
2026年2期
页码:
263-267
栏目:
临床检验
出版日期:
2026-02-05

文章信息/Info

Title:
Changes and detection significance of serum TFF1,CYFRA21-1 and uPA levels in patients with oral cancer
作者:
林 豪; 郭俊
（上海健康医学院附属崇明医院检验科，上海 202150）
Author(s):
LIN Hao; GUO Jun
(Department of Clinical Laboratory,Chongming Hospital Affiliated to Shanghai University of Medicine and Health Sciences,Shanghai 202150,China)
关键词:
口腔癌; 三叶因子1; 细胞角蛋白19片段抗原21-1; 尿激酶型纤溶酶原激活剂; 预后; 预测价值
Keywords:
Oral cancer; Trefoil factor 1; Cytokeratin 19 fragment antigen 21-1; Urokinase-type plasminogen activator; Prognosis; Predictive value
分类号:
R 739.8
DOI:
DOI:10.3969/j.issn.1000-7377.2026.02.022
文献标志码:
A
摘要:
目的：探讨口腔癌（OC）患者血清三叶因子1（TFF1）、细胞角蛋白19片段抗原21-1（CYFRA21-1）、尿激酶型纤溶酶原激活剂（uPA）水平变化及检测意义。方法：选取OC患者129例为OC组，根据患者3年生存情况分为生存组（85例）和病死组（44例），另选同期体检健康者100例为对照组。比较各组血清TFF1、CYFRA21-1、uPA水平。以多因素Logistic回归分析OC患者预后的影响因素；采用Spearman法分析血清TFF1、CYFRA21-1、uPA水平与OC患者死亡结局的相关性；通过受试者工作特征（ROC）曲线分析血清TFF1、CYFRA21-1、uPA对OC患者死亡结局的预测价值。结果：与对照组比较，OC组患者血清TFF1、CYFRA21-1、uPA水平升高（均P＜0.05）。与生存组比较，病死组患者血清TFF1、CYFRA21-1、uPA水平升高（均P＜0.05）。病死组有吸烟史、淋巴结转移、TNM分期Ⅲ-Ⅳ期、肿瘤低分化/未分化患者比例以及肿瘤浸润深度高于生存组（均P＜0.05）。有吸烟史、淋巴结转移、TNM分期Ⅲ-Ⅳ期、肿瘤低/未分化以及高血清TFF1、CYFRA21-1、uPA水平为OC患者预后的危险因素（均P＜0.05）。血清TFF1、CYFRA21-1、uPA水平与OC患者死亡结局呈正相关（均P＜0.05）。血清TFF1、CYFRA21-1、uPA联合预测OC患者死亡结局的曲线下面积（AUC）值为0.911，高于三者单独预测的AUC（均P＜0.05）。结论：OC患者血清TFF1、CYFRA21-1、uPA水平升高，三者与患者预后有关，联合检测对预后有一定预测价值。
Abstract:
Objective:To investigate the changes and detection significance of serum trefoil factor 1 (TFF1),cytokeratin 19 fragment antigen 21-1 (CYFRA21-1),and urokinase-type plasminogen activator (uPA) levels in patients with oral cancer (OC).Methods：A total of 129 OC patients were enrolled as the OC group and further divided into a survival group (85 cases) and a death group (44 cases) based on 3-year survival outcomes.Additionally,100 healthy individuals were selected as the control group.Serum levels of TFF1,CYFRA21-1 and uPA were compared among the groups.Multivariate logistic regression was used to analyze prognostic factors in OC patients.Spearman correlation analysis was applied to assess the relationship between serum TFF1,CYFRA21-1 and uPA levels and death outcomes.ROC curves were constructed to evaluate the predictive value of these biomarkers for death in OC patients.Results:Compared with the control group,serum levels of TFF1,CYFRA21-1 and uPA were significantly elevated in the OC group (all P<0.05).Compared with the survival group,the death group exhibited higher serum levels of TFF1,CYFRA21-1 and uPA (all P<0.05).The death group also had higher proportions of patients with a history of smoking,lymph node metastasis,TNM stage Ⅲ-Ⅳ,poorly differentiated/undifferentiated tumors,and greater tumor invasion depth (all P<0.05).Multivariate analysis identified a history of smoking,lymph node metastasis,TNM stage Ⅲ-Ⅳ,poor/undifferentiated tumor grade,and elevated serum levels of TFF1,CYFRA21-1,and uPA as independent risk factors for poor prognosis in OC patients (all P<0.05).Serum TFF1,CYFRA21-1,and uPA levels were positively correlated with death outcomes (all P<0.05).The AUC for the combined prediction of death using TFF1,CYFRA21-1 and uPA was 0.911,which was significantly higher than that of any single biomarker (all P<0.05).Conclusion:Serum levels of TFF1,CYFRA21-1,and uPA are elevated in OC patients and are associated with prognosis.Combined detection of these biomarkers holds predictive value for clinical outcomes.

参考文献/References:

[1]JANARDHANAN M,SANDYA C J,RAJ M,et al.Reduction in tongue space/tongue volume ratio as a risk factor for oral tongue squamous cell carcinoma-an exploratory study[J].J Oral Biol Craniofac Res,2025,15(4)：718-723.
[2]KALASKAR A R,SOMANI G A,KALASKAR R R.Evaluation and correlation of oral cancer phobia and anxiety in oral submucous fibrosis patients：A cross-sectional study[J].J Oral Biol Craniofac Res,2025,15(4)：724-728.
[3]薛瑞,续国强,杨钧婷,等.miR-181a-5p过表达慢病毒载体构建及其对OSCC细胞侵袭和迁移的影响[J].实用口腔医学杂志,2025,41(2)：193-199.
[4]郭超,法楠,黄景涛,等.肺腺癌中DNMT1表达和TFF1甲基化水平的相关性及临床意义[J].河北医学,2025,31(3)：420-425.
[5]杜伟坡,卢鑫怡,李景刚,等.血清sB7-H3、TFF1、LCN-2联合检测对乳腺癌的诊断价值[J].中国现代普通外科进展,2024,27(7)：538-542.
[6]于然,宋江园,丁玉梅,等.口腔黏膜下纤维性变及相关口腔癌患者血清SCC-Ag、Cyfra21-1、NSE及CEA的水平变化和意义[J].临床口腔医学杂志,2020,36(9)：533-536.
[7]赵波,李轶,郭珍.口腔癌患者有关辅助诊断、细胞生存、血管生成及营养支持的分析研究[J].海南医学院学报,2019,25(1)：61-64.
[8]尚伟,郑家伟.口腔及口咽癌新版TNM分期与NCCN诊治指南部分解读[J].中国口腔颌面外科杂志,2018,16(6)：533-546.
[9]SAINI J,BAKSHI J,SHARMA M,et al.Tissue inhibitor of metalloproteinase-1 (TIMP-1) expression and its prognostic significance in oral cancer patients[J].J Maxillofac Oral Surg,2025,24(3)：690-698.
[10]ZHOU S,QIN Y,LEI A,et al.The role of green synthesis metal and metal oxide nanoparticles in oral cancer therapy：A review[J].J Drug Target,2025,33(6)：853-876.
[11]郑雪莉,张建丽,谷峰.口腔癌颈部淋巴结清扫术中病理评估与预后的相关性[J].实用癌症杂志,2025,40(4)：598-602.
[12]沈天骁,颜琼程,顾春燕,等.卵巢癌患者外周血TFF1、FBLN1的表达意义及其预后评估价值[J].临床和实验医学杂志,2024,23(16)：1738-1742.
[13]李静,杨庚武,李颖,等.血清TFF1 TK1与晚期乳腺浸润性小叶癌患者白蛋白结合型紫杉醇化疗疗效及预后[J].安徽医学,2024,45(11)：1356-1361.
[14]罗恩茜,王亚兵.血清HGF、TSR、TFF1、PD-L1、CA153在乳腺癌早期诊断、淋巴结转移的预测价值及预后相关性分析[J].吉林医学,2025,46(3)：634-636.
[15]耿蕴峰,张景承,薛菲,等.血清actinin-4、TFF1及TGFBI水平对原发性肝癌患者经导管动脉化疗栓塞术后预后的预测[J].中国临床研究,2024,37(6)：880-884.
[16]丁兴龙,李庆妍,霍青,等.血清三叶因子、程序性死亡配体1、糖类抗原153、癌胚抗原在乳腺癌诊断及预后中表达及意义[J].临床军医杂志,2023,51(10)：1062-1064.
[17]李冬雅,周婷婷,葛殿奎.VEGFR-3、MMP-9、nm23-H1蛋白在口腔癌组织中的表达及其临床价值研究[J].陕西医学杂志,2024,53(11)：1558-1561,1566.
[18]王楠,席锦.口腔癌发病危险因素分析[J].陕西医学杂志,2021,50(4)：417-420.
[19]周岚,史祖宣,高黎,等.口腔黏膜下纤维性变相关口腔癌患者唾液菌群、Cyfra21-1及CAT含量变化及与其临床病理特点的关系[J].实用癌症杂志,2023,38(11)：1831-1834.
[20]王总飞,易昌盛,钱鑫,等.血小板/淋巴细胞比值、预后营养指数、细胞角质蛋白19片段抗原21-1与胸腺瘤患者临床特征及预后的关系[J].癌症进展,2024,22(9)：995-998,1003.
[21]SOMAY E,TOPKAN E,SELEK U.Reply to “proactive customized protocol for oral management in head and neck cancer patients planned for radiotherapy”[J].J Maxillofac Oral Surg,2025,24(3)：723-724.
[22]洪虓,廖圣恺,周晶,等.血清HGF、uPA、IL-17、IL-24对口腔鳞状细胞癌患者预后的影响[J].大理大学学报,2025,10(2)：60-66.
[23]冯建梅,王钟华,王芹.口腔癌患者血清UCA1、HGF、uPA水平与临床特征和预后的关系[J].分子诊断与治疗杂志,2021,13(11)：1796-1799,1804.
[24]周婷婷,谭劲,吴丹,等.姜黄素对人口腔黏膜上皮细胞系增殖及Wnt/β-catenin信号通路的影响[J].陕西中医,2022,43(9)：1155-1158.
[25]卓思源,NICOLA Cirillo,杨小如,等.逍遥散加味联合曲安奈德治疗口腔扁平苔藓肝郁血瘀证疗效研究[J].陕西中医,2024,45(7)：918-921.

相似文献/References:

[1]张树鹰,冯 瑶.沉默SOCS1基因表达对人口腔癌KB细胞增殖的机制研究*[J].陕西医学杂志,2020,49(10):1211.[doi:DOI:10.3969/j.issn.1000-7377.2020.10.003]
　ZHANG Shuying,FENG Yao..Mechanism of silencing SOCS1 gene table on proliferation of human oral cancer KB cells[J].,2020,49(2):1211.[doi:DOI:10.3969/j.issn.1000-7377.2020.10.003]
[2]王 楠,席 锦.口腔癌发病危险因素分析[J].陕西医学杂志,2021,50(4):417.[doi:DOI:10.3969/j.issn.1000-7377.2021.04.008]
　WANG Nan,XI Jin.Analysis of risk factors affecting oral cancer[J].,2021,50(2):417.[doi:DOI:10.3969/j.issn.1000-7377.2021.04.008]
[3]韦 敏,顾春梅,管燕华,等.miR-21对人口腔癌细胞株HSQ-89增殖、侵袭与迁移的影响实验研究[J].陕西医学杂志,2024,(2):157.[doi:DOI:10.3969/j.issn.1000-7377.2024.02.003]
　WEI Min,GU Chunmei,GUAN Yanhua,et al.Effect of miR-21 on proliferation,invasion and migration of human oral cancer cell line HSQ-89[J].,2024,(2):157.[doi:DOI:10.3969/j.issn.1000-7377.2024.02.003]
[4]李冬雅,周婷婷,葛殿奎.VEGFR-3、MMP-9、nm23-H1蛋白在口腔癌组织中的表达及其临床价值研究[J].陕西医学杂志,2024,(11):1558.[doi:DOI:10.3969/j.issn.1000-7377.2024.11.026]
　LI Dongya,ZHOU Tingting,GE Diankui.Expression and clinical significance of VEGFR-3,MMP-9 and nm23-H1 proteins in oral cancer tissue[J].,2024,(2):1558.[doi:DOI:10.3969/j.issn.1000-7377.2024.11.026]
[5]山雪婷,陈鲜霞,李生文,等.彩色多普勒超声联合血清TFF1、TM4SF1对甲状腺结节良恶性的鉴别诊断价值[J].陕西医学杂志,2025,54(6):775.[doi:DOI:10.3969/j.issn.1000-7377.2025.06.010]
　SHAN Xueting,CHEN Xianxia,LI Shengwen,et al.Differential diagnostic value of color Doppler ultrasound combined with serum TFF1 and TM4SF1 for benign and malignant thyroid nodules[J].,2025,54(2):775.[doi:DOI:10.3969/j.issn.1000-7377.2025.06.010]

备注/Memo

备注/Memo:
上海市自然科学基金资助项目（2024YLSRE-132065）
更新日期/Last Update: 2026-02-04