[1]陈霖,郑建民.DCE-MRI参数联合血清SGK2、ACTN4对前列腺癌患者预后的预测价值[J].陕西医学杂志,2026,(2):187-191.[doi:DOI:10.3969/j.issn.1000-7377.2026.02.007]
　CHEN Lin,ZHENG Jianmin.Predictive value of DCE-MRI parameters combined with serum SGK2 and ACTN4 for the prognosis of prostate cancer patients[J].,2026,(2):187-191.[doi:DOI:10.3969/j.issn.1000-7377.2026.02.007]
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DCE-MRI参数联合血清SGK2、ACTN4对前列腺癌患者预后的预测价值

《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
期数:
2026年2期
页码:
187-191
栏目:
临床研究
出版日期:
2026-02-05

文章信息/Info

Title:
Predictive value of DCE-MRI parameters combined with serum SGK2 and ACTN4 for the prognosis of prostate cancer patients
作者:
陈霖; 郑建民
（空军军医大学西京医院放射诊断科，陕西 西安 710032）
Author(s):
CHEN Lin; ZHENG Jianmin
(Department of Radiology,Xijing Hospital,Air Force Medical University,Xi’an 710032,China)
关键词:
前列腺癌; 动态对比增强磁共振成像; 血清/糖皮质激素调节激酶2; α-辅肌动蛋白4; 预后; 预测价值
Keywords:
Prostate cancer; Dynamic contrast-enhanced magnetic resonance imaging; Serum/glucocorticoid regulated kinase 2; Alpha-actinin 4; Prognosis; Predictive value
分类号:
R 737.25
DOI:
DOI:10.3969/j.issn.1000-7377.2026.02.007
文献标志码:
A
摘要:
目的：探讨动态对比增强磁共振成像（DCE-MRI）参数联合血清/糖皮质激素调节激酶2（SGK2）、α-辅肌动蛋白4（ACTN4）对前列腺癌（PCa）患者预后的预测价值。方法：选取120例PCa患者为观察组，另选同期100例良性前列腺增生患者为对照组，比较两组DCE-MRI参数和血清SGK2、ACTN4水平。随访1年，记录PCa患者复发或转移情况，并分为预后不良组（33例）和预后良好组（87例）。比较不同预后患者DCE-MRI参数和血清SGK2、ACTN4水平。PCa患者预后不良的影响因素以多因素Logistic回归进行分析。DCE-MRI参数联合血清SGK2、ACTN4对PCa患者预后不良的预测价值通过受试者工作特征（ROC）曲线进行分析。结果：观察组血清SGK2、ACTN4水平及DCE-MRI参数容积转运常数（Ktrans）、速率常数（Kep）、血管外细胞外容积分数（Ve）高于对照组（均P＜0.05）。预后不良组TNM分期Ⅲ期、淋巴结转移、肿瘤低和中分化程度患者比例，Gleason评分、血清前列腺特异性抗原（PSA）、SGK2、ACTN4水平及Kep、Ktrans、Ve值高于预后良好组（均P＜0.05）。PCa患者预后不良的影响因素包括TNM分期、淋巴结转移、肿瘤分化程度、Gleason评分、Ktrans值及血清SGK2、ACTN4、PSA（均P<0.05）。Ktrans值、血清SGK2、血清ACTN4以及三项联合预测PCa患者预后不良的曲线下面积（AUC）分别为0.697、0.735、0.761、0.902，联合预测的AUC最高（均P＜0.05）。结论：DCE-MRI参数及血清SGK2、ACTN4是PCa患者预后不良的影响因素，三者联合对患者预后的预测价值较高。
Abstract:
Objective:To investigate the predictive value of DCE-MRI parameters combined with serum/glucocorticoid regulated kinase 2 (SGK2) and alpha-actinin 4 (ACTN4) for the prognosis of prostate cancer (PCa) patients.Methods：A total of 120 PCa patients were selected as the observation group,and 100 patients with benign prostatic hyperplasia were selected as the control group.DCE-MRI parameters and serum levels of SGK2 and ACTN4 were compared between the two groups.All PCa patients were followed up for 1 year to record recurrence or metastasis.They were divided into a poor prognosis group (33 cases) and a good prognosis group (87 cases).DCE-MRI parameters and serum SGK2 and ACTN4 levels were compared between the two prognosis groups.Multivariate logistic regression was employed to identify independent determinants of poor prognosis.The predictive value of DCE-MRI parameters combined with serum SGK2 and ACTN4 for poor prognosis in PCa patients was analyzed using ROC curves.Results:Serum SGK2 and ACTN4 levels,as well as DCE-MRI parameters including Ktrans,Kep and Ve,were significantly higher in the observation group than in the control group (all P<0.05).The poor prognosis group had significantly higher proportions of TNM stage Ⅲ,lymph node metastasis,and low to moderate tumor differentiation,as well as higher Gleason scores,serum prostate-specific antigen (PSA),SGK2,ACTN4 levels,and Kep,Ktrans,and Ve values compared to the good prognosis group (all P<0.05).Multivariate analysis showed that TNM stage,lymph node metastasis,tumor differentiation,Gleason score,Ktrans value,and serum levels of SGK2,ACTN4 and PSA were influencing factors for poor prognosis in PCa patients (all P<0.05).The AUC for Ktrans,serum SGK2,serum ACTN4,and their combination in predicting poor prognosis were 0.697,0.735,0.761 and 0.902,respectively,with the combined model showing the highest predictive value (all P<0.05).Conclusion:DCE-MRI parameters and serum SGK2 and ACTN4 are influencing factors for poor prognosis in PCa patients.Their combination demonstrates a high predictive value for patient prognosis.

参考文献/References:

[1]程树林,杜中波,黄静,等.长链非编码RNA LINC00926调控微小RNA-331-3p对前列腺癌细胞增殖和迁移的影响[J].陕西医学杂志,2025,54(2)：170-174.
[2]FREITAS D M O,STEIN A C,BERGER M,et al.Reduced recurrence of prostate cancer with novel autologous cancer vaccine (FK-PC101) post-prostatectomy：Long-term results from a single-center phase 1/2 study[J].Future Sci OA,2025,11(1)：2550917.
[3]朱翩,杨凡,周浪.多模态MRI在前列腺癌疗效评价中的应用[J].中国CT和MRI杂志,2025,23(7)：132-134.
[4]贺煜,常莉莉,潘治军.SPECT/CT联合血清游离前列腺特异性抗原/总前列腺特异性抗原检查对前列腺癌及骨转移的诊断价值[J].陕西医学杂志,2021,50(9)：1102-1105.
[5]PENNINGTON K L,MCEWAN C M,WOODS J,et al.SGK2,14-3-3,and HUWE1 cooperate to control the localization,stability,and function of the oncoprotein PTOV1[J].Mol Cancer Res,2022,20(2)：231-243.
[6]NAGATA H,FUNAKI S,KIMURA K,et al.ACTN4 is associated with the malignant potential of thymic epithelial tumors through the β-catenin/Slug pathway[J].Cancer Sci,2024,115(11)：3636-3647.
[7]陶忆杰,赵晓平,孙仁祥.前列腺癌患者DCE-MRI、DWI影像表现及与PSA的关系[J].中国CT和MRI杂志,2024,22(6)：127-129.
[8]周定燕,何文琪,王伟,等.DCE-MRI结合DWI对前列腺癌Ki-67表达和Gleason评分的预测价值[J].磁共振成像,2024,15(9)：94-100,119.
[9]高旭.中国前列腺癌早期诊断专家共识[J].中华泌尿外科杂志,2015,36(8)：561-564.
[10]苏剑飞,牟睿宇,刘筱迪,等.贾英杰教授从“脾”论治前列腺癌[J].陕西中医,2023,44(5)：636-639.
[11]BILEN M A,LOWENTRITT B,BURBAGE S,et al.Healthcare resource utilization and costs among patients with metastatic castration-sensitive prostate cancer initiated on apalutamide or enzalutamide in the United States (2019-2023)[J].J Med Econ,2025,28(1)：1096-1109.
[12]王贵华,杨长命,徐卉卉,等.放射性125I粒子植入术联合内分泌疗法治疗前列腺癌的疗效评价[J].实用心脑肺血管病杂志,2016,24(4)：86.
[13]张蔓,吕军浩,马辉,等.磁共振T2加权像、动态增强扫描序列参数在前列腺癌中的表现及与前列腺特异性抗原水平、国际泌尿病理学会分级的相关性[J].海军医学杂志,2024,45(7)：750-755.
[14]刘敬涛,徐国良,闫拥军.前列腺癌血清SGK2及TK1表达水平与病理分期及预后的相关性研究[J].海南医学,2025,36(2)：171-175.
[15]问静,张倩,郭业松,等.双硫死亡相关基因ACTN4对肺腺癌预后的影响[J].临床与病理杂志,2024,44(6)：809-818.
[16]安宁,何宏艳,程佳琪,等.血清GP73、PGK-1联合DCE-MRI参数在前列腺癌中的临床应用价值[J].临床肿瘤学杂志,2024,29(7)：681-685.
[17]程陆林.SGK2通过上调GPX4抑制前列腺癌细胞铁死亡的作用及机制研究[D].武汉：华中科技大学,2023.
[18]许佳琪.异土木香内酯调控前列腺癌细胞凋亡和SUMO化系统的分子机制研究[D].长春:东北师范大学,2021.
[19]王明皓,崔文,刘园园,等.前列腺癌患者病灶ADC值及DCE-MRI成像参数与病理Gleason评分相关性分析[J].中国CT和MRI杂志,2021,19(11)：157-159.
[20]赵立群,刘睿,静可新,等.DCE-MRI定量参数直方图分析与老年前列腺癌患者腹腔镜根治术预后的关系[J].中国老年学杂志,2022,42(12)：2906-2909.
[21]刘凯,罗红兰,柯楠,等.DCE-MRI和IVIM-DWI在前列腺癌病理分级和临床分期中的诊断价值分析[J].中国性科学,2022,31(7)：31-35.
[22]李静,黄宝生,魏铭,等.动态对比增强磁共振成像结合表观扩散系数在前列腺癌诊断中的应用[J].实用放射学杂志,2020,36(12)：1976-1979.
[23]何亮,廖波,车能雨,等.多期动态增强磁共振成像参数联合血清前列腺特异性抗原水平预测前列腺癌患者术后预后的价值分析[J].中国性科学,2024,33(4)：21-25.
[24]CHENG L,HE Q,LIU B,et al.SGK2 promotes prostate cancer metastasis by inhibiting ferroptosis via upregulating GPX4[J].Cell Death Dis,2023,14(1)：74.
[25]成聪,许开良,曾金敏,等.血清HSP40、Actinin-4表达对前列腺癌患者术后疗效的评估作用及与预后的关系[J].国际泌尿系统杂志,2025,45(2)：13-17.

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备注/Memo

备注/Memo:
国家自然科学基金资助项目（81901698）
更新日期/Last Update: 2026-02-04