[1]孙庆,李佳佳,许舒婷,等.AP39调控细胞外信号调节激酶1/2通路促进帕金森病动物模型神经再生的研究进展[J].陕西医学杂志,2026,(1):140-封3.[doi:DOI:10.3969/j.issn.1000-7377.2026.01.026]
　SUN Qing,LI Jiajia,XU Shuting,et al.Research progress of AP39 regulating ERK1/2 pathway to promote nerve regeneration in animal models of Parkinson’s disease[J].,2026,(1):140-封3.[doi:DOI:10.3969/j.issn.1000-7377.2026.01.026]
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AP39调控细胞外信号调节激酶1/2通路促进帕金森病动物模型神经再生的研究进展

《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
期数:
2026年1期
页码:
140-封3
栏目:
综 述
出版日期:
2026-01-05

文章信息/Info

Title:
Research progress of AP39 regulating ERK1/2 pathway to promote nerve regeneration in animal models of Parkinson’s disease
作者:
孙庆; 李佳佳; 许舒婷; 木其尔; 卑红喆
（内蒙古医科大学第三临床医学院，内蒙古 包头 014000）
Author(s):
SUN Qing; LI Jiajia; XU Shuting; MU Qier; BEI Hongzhe
(Third Clinical Medical College of Inner Mongolia Medical University,Baotou 014000，China)
关键词:
帕金森病; 动物模型; AP39; 侧脑室室管膜下区; ERK1/2信号通路; 神经再生
Keywords:
Parkinson’s disease; Animal model; AP39; Subventricular zone; ERK1/2 signalpath; Nerve regeneration
分类号:
R 742
DOI:
DOI:10.3969/j.issn.1000-7377.2026.01.026
文献标志码:
A
摘要:
帕金森病（PD）是一种常见的神经退行性疾病，该病以中脑黑质多巴胺能神经元进行性退变、缺失为主要病理特征，药物治疗虽然可以有效缓解症状，但长期使用可能导致副作用的出现且无法逆转疾病进程，目前尚无治愈PD的方法。近年来动物实验表明，通过激活内源性神经干细胞（NSCs）增殖来促进脑修复成为治疗PD的新策略。侧脑室室管膜下区（SVZ）是成人大脑中NSCs的主要聚集区之一，其增殖和分化能力受多种信号通路调控，其中细胞外信号调节激酶1/2（ERK1/2）通路在细胞增殖和存活中发挥关键作用。AP39作为一种新型线粒体靶向硫化氢（H2S）供体能够调节氧化应激和线粒体功能，该化合物可能通过调节ERK1/2通路促进SVZ区神经干细胞增殖与分化。AP39对SVZ区神经再生的研究相对匮乏，该综述系统阐述了AP39通过调控ERK1/2信号通路的活性在神经保护与再生方面所体现出的潜力，可为PD的疾病治疗提供新的视角。
Abstract:
Parkinson’s disease (PD) is a common neurodegenerative disease,which is characterized by progressive degeneration and loss of dopaminergic neurons in the substantia nigra of midbrain.Although drug therapy can effectively relieve symptoms,long-term use may lead to side effects and cannot reverse the disease process.At present,there is no cure for PD.In recent years,animal experiments show that promoting brain repair by activating the proliferation of endogenous neural stem cells (NSCs) has become a new strategy to treat PD.The subventricular zone (SVZ) is one of the main gathering areas of NSCs in adult brain,and its proliferation and differentiation ability are regulated by many signal pathways,among which the extracellular signal-regulated kinase 1/2(ERK1/2) pathway plays a key role in cell proliferation and survival.AP39,as a novel mitochondrial targeted hydrogen sulfide (H2S) donor,can regulate oxidative stress and mitochondrial function,and this compound may promote the proliferation and differentiation of neural stem cells in SVZ region by regulating ERK1/2 pathway.The research on nerve regeneration in SVZ area by AP39 is relatively scarce.This review systematically expounds the potential of AP39 in nerve protection and regeneration by regulating the activity of ERK1/2 signaling pathway,which can provide a new perspective for the treatment of PD.

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备注/Memo

备注/Memo:
内蒙古医学科学院公立医院科研联合基金科技项目（2023GLLH0238）；内蒙古自治区自然科学基金资助项目（2021MS08136）；内蒙古医科大学联合项目（YKD2024LH004）；中国金属学会冶金安全与健康分会健康卫生科研项目（JKWS202403）；内蒙古自治区包头市卫生健康科技计划项目（2024WSJKKJ45）
更新日期/Last Update: 2026-01-05