[1]任越,刘亚丹,赵子琪,等.发作性睡病与2型糖尿病共病机制研究进展[J].陕西医学杂志,2026,(1):134-139.[doi:DOI:10.3969/j.issn.1000-7377.2026.01.025]
　REN Yue,LIU Yadan,ZHAO Ziqi,et al.Research advances in the comorbid mechanisms of narco lepsy and type 2 diabetes mellitus[J].,2026,(1):134-139.[doi:DOI:10.3969/j.issn.1000-7377.2026.01.025]
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发作性睡病与2型糖尿病共病机制研究进展

《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
期数:
2026年1期
页码:
134-139
栏目:
综 述
出版日期:
2026-01-05

文章信息/Info

Title:
Research advances in the comorbid mechanisms of narco lepsy and type 2 diabetes mellitus
作者:
任越; 刘亚丹; 赵子琪; 陈佳慧; 王斌
（天津中医药大学第一附属医院 国家中医针灸临床医学研究中心，天津 300381）
Author(s):
REN Yue; LIU Yadan; ZHAO Ziqi; Chen Jiahui; WANG Bin
（First Teaching Hospital of Tianjin University of Traditional Chinese Medicine，National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion，Tianjin 300381，China）
关键词:
发作性睡病; 2型糖尿病; 增食欲素; 胰岛素; 肥胖
Keywords:
Narcolepsy; Type 2 diabetes mellitus; Orexin; Insulin; Obesity
分类号:
R 587.1
DOI:
DOI:10.3969/j.issn.1000-7377.2026.01.025
文献标志码:
A
摘要:
发作性睡病是一种慢性的中枢神经系统功能失调病症，2型糖尿病主要表现为由胰岛素抵抗或胰岛素分泌缺陷引发的血糖水平升高，属于代谢性疾病范畴。根据流行病学和临床研究的证据，发作性睡病与2型糖尿病的患病风险提升之间存在关联，这种关联可能使得两者间形成一个不良的循环机制。发作性睡病患者因增食欲素缺乏导致其基础代谢率降低，睡眠时间紊乱，胰岛β细胞的损失增加，外周组织的胰岛素敏感性降低等，这些因素共同增加了发作性睡病患者肥胖和2型糖尿病的患病风险。此外，2型糖尿病患者，尤其是血糖波动较大者，常常会出现睡眠问题。了解发作性睡病、2型糖尿病的关联机制，以期为治疗二者共病的患者提供新的依据。
Abstract:
Narcolepsy is a chronic disorder of central nervous system function，and Type 2 Diabetes Mellitus is primarily characterized by elevated blood sugar levels caused by insulin resistance or insulin deficiency，which falls under the umbrella of metabolic diseases.Based on epidemiological and clinical research evidence，there is an association between Narcolepsy and an increased risk of developing Type 2 Diabetes Mellitus，which may result in a vicious cycle between the two conditions.Narcolepsy patients have a lower basal metabolic rate due to a deficiency of orexin，sleep disorders，increased loss of insulin-producing beta cells in the pancreas，and reduced insulin sensitivity in peripheral tissues，all of which contribute to an increased risk of obesity and Type 2 Diabetes Mellitus in Narcolepsy patients.Additionally，Type 2 Diabetes Mellitus patients，especially those with large fluctuations in blood sugar levels，often experience sleep problems.Understanding the link between Narcolepsy and Type 2 Diabetes Mellitus may provide new insights for treating patients with both conditions.

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备注/Memo

备注/Memo:
全国名老中医药专家传承工作室建设项目[国中医药发〔2022〕75号]；天津市南开区中医药传承创新发展示范试点项目-重点专科建设项目-内分泌科（20240318）；天津市科技计划项目（24ZXGZSY00170）
更新日期/Last Update: 2026-01-05