[1]杨晓霞,贾卿,于艳.IgA肾病患者血清Twist水平与疾病进展关系研究[J].陕西医学杂志,2026,(1):43-47,52.[doi:DOI:10.3969/j.issn.1000-7377.2026.01.007]
　YANG Xiaoxia,JIA Qing,YU Yan.Study of serum twist levels in IgA nephropathy and the relationship to progression[J].,2026,(1):43-47,52.[doi:DOI:10.3969/j.issn.1000-7377.2026.01.007]
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IgA肾病患者血清Twist水平与疾病进展关系研究

《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
期数:
2026年1期
页码:
43-47,52
栏目:
临床研究
出版日期:
2026-01-05

文章信息/Info

Title:
Study of serum twist levels in IgA nephropathy and the relationship to progression
作者:
杨晓霞; 贾卿; 于艳
（空军军医大学西京医院肾脏内科，陕西 西安 710032）
Author(s):
YANG Xiaoxia; JIA Qing; YU Yan
（Department of Nephrology,Xijing Hospital,Air Force Military Medical University,Xi’an 710032,China）
关键词:
IgA肾病; Twist; 血清; 肾间质纤维化; 终末期肾脏病; 预后
Keywords:
IgA nephropathy; Twist; Serum; Renal interstitial fibrosis; End-stage kidney disease; Outcome
分类号:
R 692
DOI:
DOI:10.3969/j.issn.1000-7377.2026.01.007
文献标志码:
A
摘要:
目的：探讨转录因子Twist水平在IgA肾病（IgAN）患者血清中的表达水平及其与IgAN进展的关系。方法：用酶联免疫吸附测定（ELISA)法对前瞻性收集的86例IgAN患者的血清Twist水平进行检测，并平均随访38个月研究血清Twist水平与IgAN患者预后的关系。结果：研究发现IgAN组血清Twist浓度明显高于健康对照组[540.5（323.1~583.2）pg/ml 与220.2（204.8~257.6）pg/ml，P<0.001]。血清Twist表达水平与IgAN患者的Lee氏分级有明显的相关性，病理分级更高的Lee氏Ⅳ-Ⅴ级患者血清Twist的表达水平显著高于Lee氏Ⅰ-Ⅱ级（P<0.001）。同时做了Spearman相关性分析发现血清Twist的表达水平与IgAN患者的估算肾小球滤过率（eGFR）呈明显负相关（r=－0.429，P<0.001），与肌酐、尿素氮、肾间质纤维化的比例呈正相关（r=0.346，P<0.001；r=0.254，P=0.003；r=0.388，P<0.001）,但在24 h尿蛋白定量、性别、年龄并没有发现明显的相关性（均P>0.05）。K-M生存曲线分析表明血清中较高水平的Twist与较低的肾脏存活率相关。Cox风险比例回归模型评估发现高浓度的血清Twist水平为IgAN独立的预后因子（HR=7.40，P<0.001）。结论：血清中高表达的Twist与IgA患者的肾脏不良预后相关，表明Twist可能是IgAN进展的一个血清生物学指标。
Abstract:
Objective:To investigate the expression levels of Twist in the serum of IgA nephropathy (IgAN) patients and the relationship to disease progression.Methods：We prospectively collected the clinical data and serum samples of 86 IgAN patients and serum Twist concentration of the participants were tested using enzyme-linked immunosorbent assay (ELISA).Results:IgAN patients had significantly higher serum Twist concentration than the health controls [540.5 (323.1-583.2)pg/ml versus 220.2（204.8-257.6）pg/ml,P<0.001].Serum Twist levels were significantly different among IgAN Lee stages,we observed that the level of Twist increased significantly at IgAN Lee grade Ⅳ-Ⅴ lesions compared with IgAN Lee grade Ⅰ-Ⅱ lesions (P<0.001).Spearman correlation analyses showed that Twist levels in the serum were inversely correlated with estimated glomerular filtration rates (eGFRs) (r=－0.429,P<0.001).In addition,positive correlations were found between serum Twist levels and serum creatinine,blood urea nitrogen,and the proportions of tubulointerstitial fibrosis (r=0.346,P<0.001;r=0.254,P=0.003;r=0.388,P<0.001;respectively).There was no significant correlation between Twist expression levels and other clinicopathological factors,including the proteinuria,gender,and age.Kaplan-Meier survival curves showed that higher serum Twist level was associated with shorter renal survival duration.Cox proportional hazard regression model analyses further demonstrated that high serum Twist concentration was an independent prognostic factor for IgAN patients (HR = 7.40,P<0.001).Conclusion:Our study showed that high circulating Twist levels were associated with adverse kidney disease outcome,suggesting that Twist is a novel biomarker for CKD progression.

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备注/Memo

备注/Memo:
国家自然科学基金资助项目（81270722）；空军军医大学西京医院学科助推项目（XJZT18MJ97）
更新日期/Last Update: 2026-01-05