[1]吴梓敬,李纪新,邱林杰,等.内脏肥胖指数与非肥胖人群高尿酸血症相关性研究及其预测价值[J].陕西医学杂志,2025,54(12):1635-1640,1649.[doi:DOI:10.3969/j.issn.1000-7377.2025.12.008]
　WU Zijing,LI Jixin,QIU Linjie,et al.Correlation between VAI and HUA,UA level in non-obese population and its predictive value[J].,2025,54(12):1635-1640,1649.[doi:DOI:10.3969/j.issn.1000-7377.2025.12.008]
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内脏肥胖指数与非肥胖人群高尿酸血症相关性研究及其预测价值

《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
54
期数:
2025年12期
页码:
1635-1640,1649
栏目:
临床研究
出版日期:
2025-12-05

文章信息/Info

Title:
Correlation between VAI and HUA,UA level in non-obese population and its predictive value
作者:
吴梓敬1; 2; 李纪新2; 邱林杰2; 任燕2; 李美洁2; 栗文婕2; 邹姹姹1; 2; 张睿3; 张晋2
（1.北京中医药大学，北京 100029；2.中国中医科学院西苑医院，北京 100091；3.福建省人民医院，福建 福州 350004）
Author(s):
WU Zijing1; 2; LI Jixin2; QIU Linjie2; REN Yan2; LI Meijie2; LI Wenjie2; ZOU Chacha1; 2; ZHANG Rui3; ZHANG Jin2
(1.Beijing University of Chinese Medicine,Beijing 100029,China;2.Xiyuan Hospital,China Academy of Traditional Chinese Medicine,Beijing 100091,China;3.Fujian Provincial People’s Hospital,Fuzhou 350004,China)
关键词:
高尿酸血症; 内脏肥胖指数; 血尿酸; 非肥胖人群; 相关性; 预测价值
Keywords:
Hyperuricemia; Visceral Adiposity Index; Uric acid; Non-obese population; Correlation; Predictive value
分类号:
R 589.7
DOI:
DOI:10.3969/j.issn.1000-7377.2025.12.008
文献标志码:
A
摘要:
目的：探究内脏肥胖指数（VAI）与非肥胖人群高尿酸血症（HUA）和血尿酸（UA）水平的相关性及其预测价值。方法：纳入参加健康体检的非肥胖成年人1553例，并对UA水平升高人群进行二次筛选，以是否患有HUA作为分组依据。采用R 4.2.0和EmpowerRCH 4.2分析VAI与非肥胖人群HUA和UA水平的相关性；依据性别、年龄、吸烟史、饮酒史和既往疾病史进行交互作用检验；采用受试者工作特征（ROC）曲线评估VAI对于非肥胖人群HUA的预测价值。结果：亚组分析显示，降低VAI对于女性、年龄≥50岁及高血压群体可带来更多的获益。当ln VAI作为连续型变量时，在校正年龄、性别、吸烟史等13种混杂因素后，非肥胖个体ln VAI每上升1个单位，被诊断为HUA的可能性升高为原来的5.13倍，UA水平升高21.30个单位（均P<0.05）。当ln VAI作为分类变量时，高VAI组别的HUA患病率是低VAI组别的9.37倍，UA水平升高65.33个单位（均P<0.05）。ROC曲线分析显示，VAI对HUA具有良好的预测价值（P<0.05）。结论：在非肥胖人群中，VAI与HUA患病率和UA水平呈显著的非线性正相关，且对HUA具有良好的预测价值，可用于非肥胖人群HUA的早期识别。
Abstract:
Objective:To investigate the association between Visceral Adiposity Index (VAI) and the hyperuricemia (HUA) as well as serum uric acid (UA) level in non-obese individuals,and to evaluate its potential predictive value.Methods：A total of 1553 non-obese adults who underwent health examinations were included in this study.A secondary screening was conducted on individuals with elevated UA level,and they were grouped based on whether they had HUA.The associations between VAI and HUA,UA level were analyzed using R 4.2.0 and EmpowerRCH 4.2.Interaction analyses were performed stratified by gender,age,smoking status,alcohol consumption history,and pre-existing medical conditions.The predictive value of VAI for HUA was assessed using ROC curve.Results:Subgroup analysis showed that reducing VAI would bring more benefits to women,individuals aged 50 years or older,and people with HUA.When ln VAI was used as a continuous variable,after adjusting for 13 potential confounding factors,including age,gender,and smoking history,each one-unit increase in ln-transformed VAI was associated with a 5.13-fold increased likelihood of being diagnosed with HUA,along with an average increase of 21.30 units in UA level (all P<0.05).When ln VAI was treated as a categorical variable,individuals in the high VAI group exhibited a 9.37-fold higher prevalence of HUA compared to those in the low VAI group,with a corresponding increase of 65.33 units in UA level (all P<0.05).ROC curve analysis showed that VAI had a good predictive value for HUA (P<0.05).Conclusion:In non-obese population,VAI has a significant non-linear positive correlation with HUA prevalence and UA level,and has a good predictive value for HUA,which can be used for the early identification of HUA in non-obese population.

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备注/Memo

备注/Memo:
国家重点研发计划子课题（2018YFC2000604）；北京中医药薪火传承“3＋3”工程项目（2023-SZ-A51）；中国中医科学院科技创新工程（CI2021A03005）；中国中医科学院西苑医院具有知识产权的医疗机构制剂和中药新药的研发与转化专项课题（XYZY0301-16）
更新日期/Last Update: 2025-12-05