[1]张兵,曹成成,潘姿璇,等.颗粒细胞程序性死亡在早发性卵巢功能不全中的作用机制研究进展[J].陕西医学杂志,2025,54(11):1566-1571.[doi:DOI:10.3969/j.issn.1000-7377.2025.11.024]
　ZHANG Bing,CAO Chengcheng,PAN Zixuan,et al.Research progress on the mechanism of granulosa cells programmed death in premature ovarian insufficiency[J].,2025,54(11):1566-1571.[doi:DOI:10.3969/j.issn.1000-7377.2025.11.024]
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颗粒细胞程序性死亡在早发性卵巢功能不全中的作用机制研究进展

《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
54
期数:
2025年11期
页码:
1566-1571
栏目:
综 述
出版日期:
2025-11-05

文章信息/Info

Title:
Research progress on the mechanism of granulosa cells programmed death in premature ovarian insufficiency
作者:
张兵1; 曹成成1; 潘姿璇1; 刘金星2; 刘鹏飞2; 李宗兰1; 于潇3
（1.山东第二医科大学附属医院，山东 潍坊 261000；2.山东中医药大学，山东 济南 250355；3.山东中医药大学附属医院，山东 济南 250014）
Author(s):
ZHANG Bing1; CAO Chengcheng1; PAN Zixuan1; LIU Jinxing2; LIU Pengfei2; LI Zonglan1; YU Xiao3
(1.Affiliated Hospital of Shandong Second Medical University,Weifang 261000,China;2.Shandong University of Traditional Chinese Medicine,Jinan 250355,China;3.Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan 250014,China)
关键词:
早发性卵巢功能不全; 颗粒细胞; 凋亡; 自噬; 铁死亡; 焦亡; 坏死性凋亡
Keywords:
Premature ovarian insufficiency; Granulosa cells; Apoptosis; Autophagy; Ferroptosis; Pyroptosis; Necroptosis
分类号:
R 711.75
DOI:
DOI:10.3969/j.issn.1000-7377.2025.11.024
文献标志码:
A
摘要:
早发性卵巢功能不全（POI）作为影响女性生理及生殖功能的常见内分泌疾病，发病率呈逐年上升趋势，其发病机制包括卵泡发育障碍和卵泡闭锁增加。颗粒细胞（GCs）作为卵泡的重要组成部分，在卵泡生长、发育、成熟、闭锁过程中发挥重要调控作用。研究发现，GCs凋亡、自噬、铁死亡、焦亡、坏死性凋亡等程序性细胞死亡参与调控卵泡闭锁过程，与卵巢功能衰竭密切相关。因此，现对GCs在卵泡发育中的作用及其程序性死亡在POI中的作用机制进行综述，以期为POI的干预提供思路。
Abstract:
Premature ovarian insufficiency (POI) is a common endocrine disease that affects women’s physiology and reproductive function,with an increasing incidence rate in recent years.Its pathogenesis includes impaired follicle development and increased follicle atresia.Granulosa cells (GCs),as an important component of the follicle,play a significant regulatory role in the growth,development,maturation and atresia of follicles.Studies have found that programmed cell death in GCs,including apoptosis,autophagy,ferroptosis,pyroptosis,and necroptosis,is involved in the regulation of follicle atresia and is closely related to ovarian failure.Therefore,this article reviews the role of GCs in follicle development and the mechanisms of their programmed death in POI,in order to provide ideas for the intervention of POI.

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备注/Memo

备注/Memo:
国家自然科学基金资助项目（82104917）
更新日期/Last Update: 2025-11-04