[1]彭敏,唐治琴,常东方.烧伤患者皮肤软组织扩张术后切口感染影响因素及血清Presepsin、PGE2检测意义[J].陕西医学杂志,2025,54(11):1500-1504.[doi:DOI:10.3969/j.issn.1000-7377.2025.11.011]
　PENG Min,TANG Zhiqin,CHANG Dongfang.Influencing factors of incision infection after skin and soft tissue expansion in burn patients and the significance of serum Presepsin and PGE2 detection[J].,2025,54(11):1500-1504.[doi:DOI:10.3969/j.issn.1000-7377.2025.11.011]
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烧伤患者皮肤软组织扩张术后切口感染影响因素及血清Presepsin、PGE2检测意义

《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
54
期数:
2025年11期
页码:
1500-1504
栏目:
临床研究
出版日期:
2025-11-05

文章信息/Info

Title:
Influencing factors of incision infection after skin and soft tissue expansion in burn patients and the significance of serum Presepsin and PGE2 detection
作者:
彭敏; 唐治琴; 常东方
（重庆医科大学附属永川医院烧伤整形外科，重庆 402160）
Author(s):
PENG Min; TANG Zhiqin; CHANG Dongfang
(Department of Burn and Plastic Surgery,the Affiliated Yongchuan Hospital of Chongqing Medical University,Chongqing 402160,China)
关键词:
烧伤; 皮肤软组织扩张术; 切口感染; 影响因素; 可溶性白细胞分化抗原14亚型; 前列腺素E2
Keywords:
Burn; Skin and soft tissue expansion; Incision infection; Influencing factors; Presepsin; Prostaglandin E2
分类号:
R 644
DOI:
DOI:10.3969/j.issn.1000-7377.2025.11.011
文献标志码:
A
摘要:
目的：探讨烧伤患者皮肤软组织扩张术后切口感染的影响因素及血清可溶性白细胞分化抗原14亚型（Presepsin）、前列腺素E2（PGE2）的检测意义。方法：选取行皮肤软组织扩张术的烧伤患者260例。依据术后是否发生切口感染将患者分为感染组（32例）和未感染组（228例）。检测感染组患者病原菌分布情况。比较两组患者血清Presepsin、PGE2水平。烧伤患者皮肤软组织扩张术后切口感染的影响因素以多因素Logistic回归进行分析。采用受试者工作特征（ROC）曲线分析血清Presepsin、PGE2对烧伤患者术后切口感染的预测价值。结果：260例行皮肤软组织扩张术的烧伤患者，发生术后切口感染32例，感染发生率12.30%。感染患者中共检出病原菌40株，革兰阴性菌和阳性菌分别26株、14株，占比65.00%、35.00%。感染组患者手术时间、扩张囊容积以及合并糖尿病、吸入性损伤、注射壶内置比例较未感染组升高（均P＜0.05）。与感染组比较，未感染组患者血清Presepsin、PGE2水平升高（均P＜0.05）。烧伤患者皮肤软组织扩张术后切口感染的影响因素包括合并糖尿病、扩张囊容积及血清Presepsin、PGE2（均P＜0.05）。血清Presepsin、PGE2单独及联合预测烧伤患者皮肤软组织扩张术后切口感染的曲线下面积（AUC）分别为0.773、0.805、0.912，且联合预测的AUC最高（均P＜0.05）。结论：合并糖尿病、扩张囊容积及血清Presepsin、PGE2是烧伤患者皮肤软组织扩张术后切口感染的影响因素，且血清Presepsin、PGE2对患者术后切口感染具有一定的预测价值。
Abstract:
Objective:To explore the influencing factors of incision infection after skin and soft tissue expansion in burn patients and the significance of detecting serum Presepsin and prostaglandin E2 (PGE2).Methods：A total of 260 burn patients who underwent skin and soft tissue expansion were selected.Patients were divided into the infection group (32 cases) and the non-infection group (228 cases) based on whether incision infection occurred after surgery.The distribution of pathogens in the infection group was detected.The levels of serum Presepsin and PGE2 were compared between the two groups.Multivariate logistic regression analysis was used to identify the influencing factors of incision infection after skin and soft tissue expansion in burn patients.ROC curve analysis was used to evaluate the predictive value of serum Presepsin and PGE2 for postoperative incision infection in burn patients.Results:Among the 260 burn patients who underwent skin and soft tissue expansion,32 cases (12.30%) developed postoperative incision infection.A total of 40 pathogens were detected in the infection group,with 26 Gram-negative bacteria (65.00%) and 14 Gram-positive bacteria (35.00%).The infection group had longer surgical time,larger expander volume,and higher proportions of diabetes mellitus,inhalation injury,and internal placement of injection ports compared with the non-infection group (all P<0.05).The levels of serum Presepsin and PGE2 were higher in the non-infection group than in the infection group (all P<0.05).The influencing factors of incision infection after skin and soft tissue expansion in burn patients included diabetes mellitus,expander volume,and serum Presepsin and PGE2 (all P<0.05).The AUC for predicting incision infection after skin and soft tissue expansion in burn patients using serum Presepsin,PGE2 alone,and in combination were 0.773,0.805 and 0.912,respectively,with the highest AUC for combined prediction (all P<0.05).Conclusion:Diabetes mellitus,expander volume,and serum Presepsin and PGE2 are influencing factors of incision infection after skin and soft tissue expansion in burn patients.Serum Presepsin and PGE2 have certain predictive value for postoperative incision infection in these patients.

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备注/Memo

备注/Memo:
重庆市自然科学基金资助项目(2021MSXM270)；重庆市永川区自然科学基金资助计划项目（2023yc-jckx20018）
更新日期/Last Update: 2025-11-04