[1]李彤,陆珍.老年原发性高血压患者心电图碎裂QRS波检出率及危险因素研究[J].陕西医学杂志,2025,54(10):1355-1359,1380.[doi:DOI:10.3969/j.issn.1000-7377.2025.10.010]
　LI Tong,LU Zhen.Analysis of the detection rate and risk factors of ECG fragmentation QRS wave in elderly patients with essential hypertension[J].,2025,54(10):1355-1359,1380.[doi:DOI:10.3969/j.issn.1000-7377.2025.10.010]
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老年原发性高血压患者心电图碎裂QRS波检出率及危险因素研究

《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
54
期数:
2025年10期
页码:
1355-1359,1380
栏目:
临床研究
出版日期:
2025-10-05

文章信息/Info

Title:
Analysis of the detection rate and risk factors of ECG fragmentation QRS wave in elderly patients with essential hypertension
作者:
李彤; 陆珍
（空军军医大学西京医院，陕西 西安 710032）
Author(s):
LI Tong; LU Zhen
（Xijing Hospital,Air Force Medical University，Xi’an 710032，China）
关键词:
老年人; 原发性高血压; 心电图; 碎裂QRS波; 左心室肥厚; 左心室舒张功能不全; 危险因素
Keywords:
Elderly; Essential hypertension; Electrocardiogram; Fragmentation of QRS complexes; Left ventricular hypertrophy; Left ventricular diastolic dysfunction; Risk factors
分类号:
R 541.3
DOI:
DOI:10.3969/j.issn.1000-7377.2025.10.010
文献标志码:
A
摘要:
目的：探讨老年原发性高血压患者心电图碎裂QRS波（fQRS）检出率及危险因素。方法：将262例老年原发性高血压患者按照体表心电图结果是否存在fQRS分为fQRS组和非fQRS组，比较两组临床资料差异，采用Spearman 秩相关分析相关指标与fQRS发生的关联性。采用多因素Logistic 回归分析影响患者心电图fQRS发生的相关因素。结果：262例患者中fQRS检出率为30.15%（79/262）。与非fQRS组比较，fQRS组年龄偏大、病程偏长、收缩压、空腹血糖、同型半胱氨酸、NT-proBNP水平偏高，LVEDD和E/e’偏大，25（OH）D水平、E/A偏低，两组比较差异有统计学意义（均P＜0.05）。Spearman秩相关分析显示，fQRS与年龄增大（r=0.283，P<0.05）、病程延长（r=0.291，P<0.05）、收缩压增高（r=0.324，P<0.05）、空腹血糖升高（r=0.195，P<0.05）、同型半胱氨酸（r=0.236，P<0.05）、NT-proBNP水平增高（r=0.267，P<0.05）、LVEDD（r=0.254，P<0.05）、E/e’增加（r=0.279，P<0.05）呈显著的正相关；与25（OH）D水平降低（r=－0.259，P<0.05）、E/A（r=－0.225，P<0.05）存在显著的负相关性。多因素Logistic回归分析显示，年龄增大、收缩压升高、同型半胱氨酸和NT-proBNP水平增高、E/e’增大、25（OH）D水平降低与老年原发性高血压患者出现fQRS呈独立相关（均P＜0.05）。结论：老年高血压患者心电图fQRS检出率较高，年龄增大、收缩压升高、同型半胱氨酸和NT-proBNP水平增高、E/e’增大，25（OH）D水平降低是fQRS出现的独立危险因素。
Abstract:
Objective:To investigate the detection rate and risk factors of ECG fragmented QRS complex (fQRS) in elderly patients with essential hypertension.Methods：A total of 262 elderly patients with essential hypertension diagnosed and treated in our hospital from March 2022 to May 2024 were selected as the research subjects,and they were divided into fQRS group and non-fQRS group according to the presence or absence of fQRS on the surface ECG results,and the differences in clinical data between the two groups were compared,and the correlation between the relevant indicators and the occurrence of fQRS was analyzed by Spearman rank correlation analysis.Multivariate logistic regression analysis was used to analyze the factors affecting the occurrence of fQRS on ECG.Results:The detection rate of fQRS in 262 patients was 30.15%(79/262).Compared with the non-fQRS group,the fQRS group was older,had a longer course of disease,had higher systolic blood pressure,fasting blood glucose,homocysteine,and NT-proBNP levels,higher LVEDD and E/e’ levels,and lower 25(OH)D levels and E/A levels,and the differences between the two groups were statistically significant (all P<0.05).Spearman rank correlation analysis showed that fQRS was associated with increased age (r=0.283,P<0.05),prolonged disease duration (r=0.291,P<0.05),increased systolic blood pressure (r=0.324,P<0.05),increased fasting blood glucose (r=0.195,P<0.05),homocysteine (r=0.236,P<0.05),increased levels of NT-proBNP (r=0.267,P<0.05),increased LVEDD (r=0.254,P<0.05),and increased E/e’ (r=0.279,P<0.05) showed a significant positive correlation;There was a significant negative correlation with the decrease of 25(OH)D level (r=－0.259,P<0.05) and E/A (r=－0.225,P<0.05).Multivariate Logistic regression analysis showed that the increase of age,the increase of systolic blood pressure,the increase of homocysteine and NT-proBNP levels,the increase of E/e’,and the decrease of 25(OH)D level were independently associated with the occurrence of fQRS in elderly patients with essential hypertension (all P<0.05).Conclusion:The detection rate of ECG fQRS is higher in elderly patients with hypertension,and the independent risk factors for fQRS are increasing age,increasing systolic blood pressure,increasing levels of homocysteine and NT-proBNP,increasing E/e’,and decreasing 25(OH)D level.

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备注/Memo

备注/Memo:
陕西省重点研发计划项目（2023-YBSF-512）
更新日期/Last Update: 2025-10-09