[1]徐丹,桂明才,周长华,等.老年突发性耳聋患者血清HMGB1、Cx43、TXB2水平变化及检测意义[J].陕西医学杂志,2025,54(8):1108-1112.[doi:DOI:10.3969/j.issn.1000-7377.2025.08.020]
　XU Dan,GUI Mingcai,ZHOU Changhua,et al.Changes and detection significance of serum HMGB1,Cx43 and TXB2 levels in elderly patients with sudden deafness[J].,2025,54(8):1108-1112.[doi:DOI:10.3969/j.issn.1000-7377.2025.08.020]
点击复制

老年突发性耳聋患者血清HMGB1、Cx43、TXB2水平变化及检测意义

《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
54
期数:
2025年8期
页码:
1108-1112
栏目:
临床检验
出版日期:
2025-08-05

文章信息/Info

Title:
Changes and detection significance of serum HMGB1,Cx43 and TXB2 levels in elderly patients with sudden deafness
作者:
徐丹; 桂明才; 周长华; 李聪
（达州市中心医院耳鼻咽喉头颈外科，四川 达州 635000）
Author(s):
XU Dan; GUI Mingcai; ZHOU Changhua; LI Cong
(Department of Otolaryngology Head and Neck Surgery,Dazhou Central Hospital,Dazhou 635000,China)
关键词:
突发性耳聋; 老年; 高迁移率族蛋白B1; 缝隙连接蛋白43; 血栓素B2; 影响因素
Keywords:
Sudden deafness; Elderly; HMGB1; Cx43; TXB2; Influencing factors
分类号:
R 764.43
DOI:
DOI:10.3969/j.issn.1000-7377.2025.08.020
文献标志码:
A
摘要:
目的：探讨老年突发性耳聋患者血清高迁移率族蛋白B1（HMGB1）、缝隙连接蛋白43（Cx43）、血栓素B2（TXB2）水平变化及其检测意义。方法：选取老年突发性耳聋患者108例为突发性耳聋组，根据纯音听阈曲线将患者分为轻度耳聋组（42例）、中度耳聋组（36例）和重度耳聋组（30例）。另选93例无耳部疾病史的老年人为对照组。比较对照组和突发性耳聋组、不同听力损失程度患者血清HMGB1、Cx43、TXB2水平。采用多因素Logistic回归分析老年突发性耳聋发生的影响因素。结果：与对照组比较，突发性耳聋组血清HMGB1、TXB2水平升高，血清Cx43水平降低（均P＜0.05）。轻度耳聋组患者血清HMGB1、TXB2水平低于中度耳聋组，且中度耳聋组低于重度耳聋组（均P＜0.05）。轻度耳聋组患者血清Cx43水平高于中度耳聋组，且中度耳聋组高于重度耳聋组（均P＜0.05）。与对照组比较，突发性耳聋组有糖尿病史、睡眠障碍、感冒病史、血清总胆固醇（TC）≥5.70 mmol/L及同型半胱氨酸（Hcy）≥16.00 μmol/L比例升高（均P＜0.05）。有糖尿病史、睡眠障碍、感冒病史、血清TC≥5.70 mmol/L、Hcy≥16.00 μmol/L、HMGB1≥2.12 mg/L、TXB2≥209.89 pg/ml及Cx43≤147.34 pg/ml是老年突发性耳聋发生的危险因素（均P＜0.05）。结论：老年突发性耳聋患者血清HMGB1、TXB2水平升高，血清Cx43水平降低，三者与听力损失程度有关，是老年突发性耳聋发生的影响因素。
Abstract:
Objective:To explore the changes in the levels of serum high mobility group protein B1 (HMGB1),connexin 43 (Cx43) and thromboxane B2 (TXB2) in elderly patients with sudden deafness and their detection significance.Methods：A total of 108 elderly patients with sudden deafness were selected as the sudden deafness group,and were further divided into mild hearing loss group (42 cases),moderate hearing loss group (36 cases) and severe hearing loss group (30 cases) based on pure tone audiometry threshold curve.Another 93 elderly individuals without a history of ear disease were chosen as the control group.The serum levels of HMGB1,Cx43 and TXB2 were compared between the control group and the sudden deafness group,as well as among patients with different degrees of hearing loss.Multivariate logistic regression analysis was used to identify the influencing factors for the occurrence of sudden deafness in the elderly.Results:Compared with the control group,the serum levels of HMGB1 and TXB2 were increased,while the serum level of Cx43 was decreased in the sudden deafness group (all P<0.05).The serum levels of HMGB1 and TXB2 in the mild hearing loss group were lower than those in the moderate hearing loss group,and the moderate hearing loss group had lower levels than the severe hearing loss group (all P<0.05).The serum level of Cx43 in the mild hearing loss group was higher than that in the moderate hearing loss group,and the moderate hearing loss group had a higher level than the severe hearing loss group (all P<0.05).Compared with the control group,the proportion of patients with a history of diabetes,sleep disorders,a history of cold,serum total cholesterol (TC)≥5.70 mmol/L and homocysteine (Hcy)≥16.00 μmol/L was increased in the sudden deafness group (all P<0.05).A history of diabetes,sleep disorders,a history of cold,serum TC≥5.70 mmol/L,Hcy≥16.00 μmol/L,HMGB1≥2.12 mg/L,TXB2≥209.89 pg/ml and Cx43≤147.34 pg/ml were identified as risk factors for sudden deafness in the elderly (all P<0.05).Conclusion:The serum levels of HMGB1 and TXB2 are increased,while the serum level of Cx43 is decreased in elderly patients with sudden deafness.These three factors are associated with the degree of hearing loss and are influencing factors for the occurrence of sudden deafness in the elderly.

参考文献/References:

[1]康欣,李海朋,董亚男,等.颈部超声血流参数与突发性耳聋听力损失程度及转归不良的关系分析[J].影像科学与光化学,2025,43(3):57-66.
[2]KOMATSUBARA Y,TACHIBANA T,KATAOKA Y,et al.Application of intratympanic steroid injection as salvage therapy for idiopathic sudden sensorineural hearing loss[J].Auris Nasus Larynx,2025,52(3):248-252.
[3]TSUZUKI N,MASUDA K,YAMANOBE Y,et al.Idiopathic sudden sensorineural hearing loss caused by infarction of the vestibulo-cochlear artery can be detected by testing semicircular canal function and audiometry:Proposal for angiopathic sudden sensorineural hearing loss[J].Otol Neurotol,2025,46(5):616-620.
[4]蔡玉兵.HMGB1和ENA-78在突发性耳聋患者治疗前后的变化[J].中国医药导刊,2013(7):1198-1199.
[5]周寅飞,孙鹏,黄熹.分泌性中耳炎患者耳积液IL-6、HMGB1与外周血T淋巴细胞亚群变化及临床意义[J].中南医学科学杂志,2024,52(6):1050-1052.
[6]王莹,兰艳丽,涂晓敏,等.CMV致感音神经性耳聋患儿氧化应激指标、Cx43变化及意义[J].临床误诊误治,2023,36(4):92-96.
[7]潘媛媛,程标,陶雪飞,等.单核细胞与高密度脂蛋白胆固醇比值和血栓素B2水平与老年心房颤动左心耳血栓的关系[J].中华老年心脑血管病杂志,2025,27(1):18-21.
[8]中华耳鼻咽喉头颈外科杂志编辑委员会,中华医学会耳鼻咽喉头颈外科学分会.突发性聋诊断和治疗指南(2015)[J].中华耳鼻咽喉头颈外科杂志,2015,50(6):443-447.
[9]计莉,陈登胜,刘忠意,等.突发性聋伴良性阵发性位置性眩晕患者的临床特征分析[J].北京医学,2025,47(3):195-199.
[10]NITTA Y,SANO H,KURIOKA T,et al.Intratympanic injection of edaravone for idiopathic sudden sensorineural hearing loss with profound hearing loss[J].J Int Adv Otol,2025,21(3):1-7.
[11]CANAKCI H,ARSLAN E,TULACI K,et al.Intratympanic steroid via saturated gelfoam vs.intratympanic injection for sudden sensorineural hearing loss[J].Auris Nasus Larynx,2025,52(4):314-318.
[12]张晓辉,吴文武,王雪萍,等.血小板参数对突发性耳聋患者听力损伤程度的评估价值[J].中华耳科学杂志,2025,23(1):8-15.
[13]章仙芳.掩蔽疗法对突发性耳聋伴耳鸣患者耳鸣情况及血清VCAM-1、HMGB1水平的影响[J].吉林医学,2022,43(3):655-656.
[14]阿不拉江·托合提,阿布利克木·依,吾买尔·亚生,等.沉默HMGB1通过抑制p38 MAPK信号通路减少LPS或IL-17A诱导的中耳腔上皮细胞的炎症与凋亡[J].河北医学,2024,30(5):724-730.
[15]秦志玲.鼠神经生长因子辅助治疗突发性耳聋的疗效及对患者血清sVCAM-1、VE-cadherin、HMGB1表达的影响[J].海峡药学,2019,31(3):189-191.
[16]牛善利,黄友敏,周永勤,等.突发性耳聋患者HMGB1和ENA-78含量在治疗前后变化的意义[J].中华临床医师杂志:电子版,2011,5(4):1059-1062.
[17]吴亮,王海林,蔡艳艳.鼠神经生长因子治疗突发性耳聋的疗效及改善患者听力和疾病相关指标的研究[J].系统医学,2023,8(4):132-134,142.
[18]牛善利,黄友敏,周永勤.突发性耳聋患者HMGB1和VE-cadherin含量变化的意义[J].中华全科医学,2011,9(3):394-395,487.
[19]戴吉,李泽文,徐义策,等.突发性耳聋患者血清VCAM-1、ENA-78、MMP-2水平变化及检测意义[J].陕西医学杂志,2025,54(2):248-252.
[20]李雅琼,袁国丽.老年突发性耳聋患者听力损失情况及其与血脂水平相关性研究[J].陕西医学杂志,2022,51(7):820-822,827.
[21]刘国强,郭琳娟,贺阿利,等.放血联合电针治疗突发性耳聋临床研究[J].陕西中医,2024,45(7):980-984.
[22]田永远,吴学志,张安东,等.清肝通窍汤治疗肝火上扰型暴聋患者临床研究[J].陕西中医,2018,39(11):1548-1550,1568.
[23]黄兴玉,饶澄,苏琳凌,等.Cx43在老年性聋小鼠耳蜗中的表达及意义[J].遵义医科大学学报,2022,45(5):632-637.
[24]LIU Y,CHEN X,SHEN X,et al.Comparison of vHIT deficits with Ramsay Hunt syndrome with dizziness,vestibular neuritis,and idiopathic sudden sensorineural hearing loss with vertigo[J].J Vestib Res,2025,35(3):121-131.
[25]鄢华峰,朱虹,张艳娥.突发性耳聋病人血清Cx43、GABA水平及其与听力功能的相关性[J].蚌埠医学院学报,2024,49(11):1472-1475.

相似文献/References:

[1]徐 玫.早期目标导向治疗老年脓毒性休克的抢救效果及疗效影响因素分析[J].陕西医学杂志,2019,(4):488.
　XU Mei..Effect of early goaloriented treatment on septic shock in elderly patients and its influencing factors[J].,2019,(8):488.
[2]贾晶晶,殷 娟,焦飞燕.重症监护室老年患者肺部感染细菌耐药性研究[J].陕西医学杂志,2019,(7):890.
[3]王小林,马任远,张 哲.腹腔镜手术治疗老年进展期胃癌50例临床疗效分析[J].陕西医学杂志,2019,(10):1360.
[4]徐王兵,李 勇△,钟发明,等.两种脊柱微创手术治疗老年L5/S1椎间盘突出症疗效比较及对患者VAS及JOA评分的影响*[J].陕西医学杂志,2020,49(1):72.
　XU Wangbing,LI Yong,ZHONG Faming,et al.Curative effect of two spinal minimally invasive surgeries in the treatment of elderly patients with L5/S1 lumbar discherniation and the influence on VAS and JOA scores[J].,2020,49(8):72.
[5]吴 晋.替普瑞酮治疗老年HP阳性慢性萎缩性胃炎临床效果分析[J].陕西医学杂志,2021,50(6):735.[doi:DOI:10.3969/j.issn.1000-7377.2021.06.024]
[6]李雅琼,袁国丽.老年突发性耳聋患者听力损失情况及其与血脂水平相关性研究[J].陕西医学杂志,2022,51(7):820.[doi:DOI:10.3969/j.issn.1000-7377.2022.07.012]
　LI Yaqiong,YUAN Guoli.Hearing loss in elderly patients with sudden deafness and its correlation with blood lipid levels[J].,2022,51(8):820.[doi:DOI:10.3969/j.issn.1000-7377.2022.07.012]
[7]袁 媛,李 辉,周卫东.半胱氨酸天冬氨酸蛋白酶3、微小RNA-431和可溶性血管细胞黏附分子-1在突发性耳聋患者血清中的水平变化及其与耳蜗功能相关性研究[J].陕西医学杂志,2024,(11):1534.[doi:DOI:10.3969/j.issn.1000-7377.2024.11.021]
　YUAN Yuan,LI Hui,ZHOU Weidong.Changes in serum levels of Caspase-3,miR-431 and sVCAM-1 in patients with sudden deafness and their correlation with cochlear function[J].,2024,(8):1534.[doi:DOI:10.3969/j.issn.1000-7377.2024.11.021]
[8]戴 吉,李泽文,徐义策,等.突发性耳聋患者血清VCAM-1、ENA-78、MMP-2水平变化及检测意义[J].陕西医学杂志,2025,54(2):248.[doi:DOI:10.3969/j.issn.1000-7377.2025.02.022]
　DAI Ji,LI Zewen,XU Yice,et al.Changes and detection significance of serum VCAM-1,ENA-78 and MMP-2 levels in patients with sudden deafness[J].,2025,54(8):248.[doi:DOI:10.3969/j.issn.1000-7377.2025.02.022]
[9]周浩然,郑志杰,李瑞忠.血清PTX3、ANXA2、IL-33在老年骨质疏松症患者中的表达变化及其预测并发骨折价值[J].陕西医学杂志,2025,54(6):819.[doi:DOI:10.3969/j.issn.1000-7377.2025.06.019]
　ZHOU Haoran,ZHENG Zhijie,LI Ruizhong.Expression of serum PTX3,ANXA2 and IL-33 in elderly patients with osteoporosis and their predictive value for fracture[J].,2025,54(8):819.[doi:DOI:10.3969/j.issn.1000-7377.2025.06.019]
[10]董平,衣欣,吴威,等.老年营养风险指数、尖瓣环收缩期位移与肺动脉收缩压比值在老年射血分数保留心力衰竭患者预后评估中的价值[J].陕西医学杂志,2025,54(7):944.[doi:DOI:10.3969/j.issn.1000-7377.2025.07.014]
　DONG Ping,YI Xin,WU Wei,et al.The value of GNRI and TAPSE/PASP ratio in prognostic evaluation of elderly heart failure patients with preserved ejection fraction[J].,2025,54(8):944.[doi:DOI:10.3969/j.issn.1000-7377.2025.07.014]

备注/Memo

备注/Memo:
四川省医学（青年创新）科研课题（S22064)
更新日期/Last Update: 2025-08-04