[1]赵丽红,赵英,郑秋霞,等.子痫前期患者血清CTRP9、RBP4、PSG1水平变化及检测意义[J].陕西医学杂志,2025,54(8):1098-1102.[doi:DOI:10.3969/j.issn.1000-7377.2025.08.018]
　ZHAO Lihong,ZHAO Ying,ZHENG Qiuxia,et al.Changes and detection significance of serum CTRP9,RBP4 and PSG1 levels in patients with preeclampsia[J].,2025,54(8):1098-1102.[doi:DOI:10.3969/j.issn.1000-7377.2025.08.018]
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子痫前期患者血清CTRP9、RBP4、PSG1水平变化及检测意义

《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
54
期数:
2025年8期
页码:
1098-1102
栏目:
临床检验
出版日期:
2025-08-05

文章信息/Info

Title:
Changes and detection significance of serum CTRP9,RBP4 and PSG1 levels in patients with preeclampsia
作者:
赵丽红; 赵英; 郑秋霞; 朱润; 袁瑞娇; 杨柳; 李洪英
（昆明医科大学附属曲靖医院产科，云南 曲靖 655000）
Author(s):
ZHAO Lihong; ZHAO Ying; ZHENG Qiuxia; ZHU Run; YUAN Ruijiao; YANG Liu; LI Hongying
(Department of Obstetrics,Affiliated Qujing Hospital of Kunming Medical University,Qujing 655000,China)
关键词:
子痫前期; C1q/肿瘤坏死因子相关蛋白9; 视黄醇结合蛋白4; 妊娠特异性β1糖蛋白1; 影响因素; 诊断价值
Keywords:
Preeclampsia; CTRP9; RBP4; PSG1; Influencing factors; Diagnostic value
分类号:
R 714.25
DOI:
DOI:10.3969/j.issn.1000-7377.2025.08.018
文献标志码:
A
摘要:
目的：探讨子痫前期（PE）患者血清C1q/肿瘤坏死因子相关蛋白9（CTRP9）、视黄醇结合蛋白4（RBP4）、妊娠特异性β1糖蛋白1（PSG1）水平变化及检测意义。方法：选取102例PE患者为观察组，136例产检健康孕妇为对照组。根据病情严重程度将观察组患者分为轻度PE组（64例）和重度PE组（38例）。采用ELISA法检测各组血清CTRP9、RBP4、PSG1水平；多因素Logistic回归分析孕妇发生PE的影响因素；血清CTRP9、RBP4、PSG1对孕妇PE发生的诊断价值通过绘制受试者工作特征（ROC）曲线进行分析。结果：与对照组比较，观察组血清RBP4水平升高，CTRP9、PSG1水平降低（均P＜0.05）。与轻度PE组比较，重度PE组血清RBP4水平升高，血清CTRP9、PSG1水平降低（均P＜0.05）。观察组孕前体重指数（BMI）、三酰甘油（TG）、低密度脂蛋白胆固醇（LDL-C）高于对照组，高密度脂蛋白胆固醇（HDL-C）低于对照组（均P＜0.05）。妊娠期糖尿病或肾病、PE史、血清RBP4、CTRP9、PSG1为孕妇发生PE的独立影响因素（均P＜0.05）。血清CTRP9、RBP4、PSG1单独及联合诊断孕妇PE发生的曲线下面积（AUC）分别为0.783、0.836、0.852、0.943，且联合诊断的AUC最高（均P＜0.05）。结论：PE患者血清CTRP9、PSG1水平降低，血清RBP4水平升高，且三者联合对PE的诊断有一定价值。
Abstract:
Objective:To explore the changes in serum CTRP9,RBP4 and PSG1 levels in patients with preeclampsia (PE) and the significance of their detection.Methods：A total of 102 PE patients were selected as the observation group,and 136 healthy pregnant women undergoing prenatal examinations were selected as the control group.The observation group was further divided into mild PE group (64 cases) and severe PE group (38 cases) based on the severity of the condition.The serum levels of CTRP9,RBP4 and PSG1 in each group were detected by ELISA.Multivariate logistic regression analysis was used to identify the influencing factors for the occurrence of PE in pregnant women.The diagnostic value of serum CTRP9,RBP4 and PSG1 for PE was analyzed by ROC curves.Results:Compared with the control group,the serum RBP4 level in the observation group was increased,while the serum CTRP9 and PSG1 levels were decreased (all P<0.05).Compared with the mild PE group,the serum RBP4 level in the severe PE group was increased,while the serum CTRP9 and PSG1 levels were decreased (all P<0.05).The pre-pregnancy BMI,TG and LDL-C in the observation group were higher than those in the control group,while the HDL-C was lower than that in the control group (all P<0.05).Gestational diabetes or nephropathy,history of PE,serum RBP4,CTRP9 and PSG1 were identified as independent influencing factors for the occurrence of PE in pregnant women (all P<0.05).The AUC for the diagnosis of PE in pregnant women by serum CTRP9,RBP4,PSG1 alone and in combination were 0.783,0.836,0.852 and 0.943,respectively,with the highest AUC for combined diagnosis (all P<0.05).Conclusion:The serum levels of CTRP9 and PSG1 in PE patients were decreased,while the serum RBP4 level was increased.The combination of the three has certain diagnostic value for PE.

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备注/Memo

备注/Memo:
国家自然科学基金资助项目（81660545）
更新日期/Last Update: 2025-08-04