[1]潘志刚.超声弹性成像联合血清miR-26b-5p、miR-210检测对子宫肌瘤的诊断价值[J].陕西医学杂志,2025,54(8):1080-1084.[doi:DOI:10.3969/j.issn.1000-7377.2025.08.014]
　PAN Zhigang.Diagnostic value of ultrasound elastography combined with serum miR-26b-5p and miR-210 detection for uterine fibroids[J].,2025,54(8):1080-1084.[doi:DOI:10.3969/j.issn.1000-7377.2025.08.014]
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超声弹性成像联合血清miR-26b-5p、miR-210检测对子宫肌瘤的诊断价值

《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
54
期数:
2025年8期
页码:
1080-1084
栏目:
临床研究
出版日期:
2025-08-05

文章信息/Info

Title:
Diagnostic value of ultrasound elastography combined with serum miR-26b-5p and miR-210 detection for uterine fibroids
作者:
潘志刚
（南京中医药大学常熟附属医院超声科，江苏 常熟 215500）
Author(s):
PAN Zhigang
(Department of Ultrasound,Changshu Affiliated Hospital of Nanjing University of Chinese Medicine,Changshu 215500,China)
关键词:
子宫肌瘤; 超声弹性成像; 微小RNA-26b-5p; 微小RNA-210; 影响因素; 诊断价值
Keywords:
Uterine fibroids; Ultrasound elastography; miR-26b-5p; miR-210; Influencing factors; Diagnostic value
分类号:
R 737.33
DOI:
DOI:10.3969/j.issn.1000-7377.2025.08.014
文献标志码:
A
摘要:
目的：探讨超声弹性成像联合血清微小RNA26b-5p（miR-26b-5p）、miR-210检测对子宫肌瘤的诊断价值。方法：选取子宫肌瘤患者100例为子宫肌瘤组，同期子宫腺肌病患者80例为子宫腺肌病组。比较两组血清miR-26b-5p、miR-210水平及超声弹性成像检查结果。采用多因素Logistic回归分析子宫肌瘤发生的影响因素。超声弹性成像联合血清miR-26b-5p、miR-210对子宫肌瘤的诊断价值通过绘制受试者工作特征（ROC）曲线以及采用四格表法进行分析。结果：子宫肌瘤组超声弹性成像阳性比例、血清miR-210水平高于子宫腺肌病组，血清miR-26b-5p水平低于子宫腺肌病组（均P＜0.05）。两组在乳腺增生、流产次数、腹壁脂肪厚度方面比较差异有统计学意义（均P＜0.05）。腹壁脂肪厚度、超声弹性成像结果、血清miR-210、血清miR-26b-5p是子宫肌瘤发生的独立影响因素（均P＜0.05）。血清miR-26b-5p、miR-210及超声弹性成像联合诊断子宫肌瘤的阳性预测值、阴性预测值、准确率高于三者独立检测（均P＜0.05）。结论：血清miR-210在子宫肌瘤患者中表达升高，血清miR-26b-5p表达降低，超声弹性成像与两者联合对子宫肌瘤具有一定的诊断价值。
Abstract:
Objective:To explore the diagnostic value of ultrasound elastography combined with serum miR-26b-5p and miR-210 detection for uterine fibroids.Methods：A total of 100 patients with uterine fibroids were selected as the uterine fibroid group,and 80 patients with adenomyosis were selected as the adenomyosis group during the same period.The levels of serum miR-26b-5p and miR-210,as well as the results of ultrasound elastography,were compared between the two groups.Multivariate logistic regression analysis was used to identify the influencing factors of uterine fibroids.The diagnostic value of ultrasound elastography combined with serum miR-26b-5p and miR-210 for uterine fibroids was analyzed by plotting receiver operating characteristic (ROC) curves and using the fourfold table method.Results:The positive rate of ultrasound elastography and the level of serum miR-210 were higher in the uterine fibroid group than in the adenomyosis group,while the level of serum miR-26b-5p was lower in the uterine fibroid group than in the adenomyosis group (all P<0.05).There were statistically significant differences between the two groups in terms of breast hyperplasia,number of abortions,and abdominal wall fat thickness (all P<0.05).Abdominal wall fat thickness,ultrasound elastography results,serum miR-210,and serum miR-26b-5p were independent influencing factors for the occurrence of uterine fibroids (all P<0.05).The positive predictive value,negative predictive value,and accuracy of combined diagnosis of serum miR-26b-5p,miR-210 and ultrasound elastography for uterine fibroids were higher than those of individual detection (all P<0.05).Conclusion:The expression of serum miR-210 is upregulated in patients with uterine fibroids,while the expression of serum miR-26b-5p is downregulated.Ultrasound elastography combined with these two markers has certain diagnostic value for uterine fibroids.

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备注/Memo

备注/Memo:
江苏省重点研发计划项目（BJS202410396）
更新日期/Last Update: 2025-08-04