[1]闫志焕,胡素芹,罗磊,等.山奈酚抗消化道肿瘤作用及分子机制研究进展[J].陕西医学杂志,2025,54(6):840-845.[doi:DOI:10.3969/j.issn.1000-7377.2025.06.023]
　YAN Zhihuan,HU Suqin,LUO Lei,et al.Research Progress on anti-tumor effects and molecular mechanismes of Kaempferol in digestive tract[J].,2025,54(6):840-845.[doi:DOI:10.3969/j.issn.1000-7377.2025.06.023]
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山奈酚抗消化道肿瘤作用及分子机制研究进展

《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
54
期数:
2025年6期
页码:
840-845
栏目:
综 述
出版日期:
2025-06-05

文章信息/Info

Title:
Research Progress on anti-tumor effects and molecular mechanismes of Kaempferol in digestive tract
作者:
闫志焕1; 胡素芹2; 罗磊2; 李明彦2; 胡洋1; 曾朔1; 许阳1; 吴文涛1; 张勤生1; 2
（1.河南中医药大学第二临床医学院，河南 郑州 450002；2.河南省中医院 河南中医药大学第二附属医院，河南 郑州 450002）
Author(s):
YAN Zhihuan1; HU Suqin2; LUO Lei2; LI Mingyan2; HU Yang1; ZENG Shuo1; XU Yang1; WU Wentao1; ZHANG Qinsheng1; 2
(1.The Second Clinical Medical College of Henan University of Traditional Chinese Medicine,Zhengzhou 450002,China;2.Henan Provincial Hospital of Traditional Chinese Medicine,Zhengzhou 450002,China)
关键词:
消化道肿瘤; 山奈酚; 抗肿瘤; 诱导自噬; 促凋亡; 阻滞周期; 分子机制
Keywords:
Gastrointestinal tumors; Kaempferol; Anti-tumor; Induction of autophagy; Promoting apoptosis; Cycle of arrest; Molecular mechanisms
分类号:
R 735
DOI:
DOI:10.3969/j.issn.1000-7377.2025.06.023
文献标志码:
A
摘要:
消化道肿瘤在中国癌症排名前7位中占了4位。临床上，早期肿瘤患者多采用手术治疗，中晚期多采用放化疗和免疫治疗。然而，化疗药物的耐药性及其诱发的严重不良反应均导致患者预后较差。天然中药分子与抗癌药物联合增强抗癌效果为肿瘤治疗提供了新的策略。山奈酚（KMP）是一种天然的类黄酮，存在于多种中草药，具有抗癌、保肝、保胃等作用，其主要通过诱导细胞自噬、促进细胞凋亡、阻滞细胞周期、抑制肿瘤转移及侵袭、抑制肿瘤多重耐药及药物递送等抗肿瘤机制发挥作用。现对KMP 抗消化道肿瘤作用及分子作用机制进行综述。
Abstract:
Gastrointestinal tumors account for 4 of the top 7 cancers in China.Clinically,patients with early-stage tumors are mostly treated with surgery,and chemoradiotherapy and immunotherapy are mostly used in the middle and advanced stages.However,resistance to chemotherapeutic drugs and the serious adverse reactions induced by them lead to poor prognosis.The combination of natural TCM molecules and anti-cancer drugs to enhance the anti-cancer effect provides a new strategy for tumor treatment.Kaempferol (KMP) is a natural flavonoid,which exists in a variety of Chinese herbal medicines,with anti-cancer,hepatoprotective,gastric protective effects,etc.,and its anti-tumor mechanism is mainly by inducing autophagy,promoting apoptosis,arresting the cell cycle,inhibiting tumor metastasis and invasion,inhibiting tumor multi-drug resistance and drug delivery.This article reviews the anti-gastrointestinal tumor effects and molecular mechanisms of KMP.

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备注/Memo

备注/Memo:
国家自然科学基金资助项目（82305074）；国家中医药管理局中国中医药科技发展中心联合研究项目（CXZH202304）；国家中医药管理局中医药循证能力提升项目（2019XZZX-XH005）；河南省中医药传承与创新人才工程（仲景工程）中医药学科领军人才项目（豫卫中医函[2021]08号）；河南省重点研发与推广专项（科技攻关）支持项目（222102310240）；河南省中医药科学研究专项课题（2023ZY2074）
更新日期/Last Update: 2025-06-04