[1]姚岚,郭菲,宋莉,等.血清LBP、presepsin、LDH联合检测对结直肠癌术后患者肠梗阻发生的预测价值[J].陕西医学杂志,2025,54(6):800-803,824.[doi:DOI:10.3969/j.issn.1000-7377.2025.06.015]
 YAO Lan,GUO Fei,SONG Li,et al.Predictive value of combined detection of serum LBP,presepsin and LDH for intestinal obstruction after colorectal cancer surgery[J].,2025,54(6):800-803,824.[doi:DOI:10.3969/j.issn.1000-7377.2025.06.015]
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血清LBP、presepsin、LDH联合检测对结直肠癌术后患者肠梗阻发生的预测价值

《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
54
期数:
2025年6期
页码:
800-803,824
栏目:
临床研究
出版日期:
2025-06-05

文章信息/Info

Title:
Predictive value of combined detection of serum LBP,presepsin and LDH for intestinal obstruction after colorectal cancer surgery
作者:
姚岚1郭菲1宋莉1廖新华2
(1.西安交通大学第一附属医院手术室,陕西 西安 710061;2.西安交通大学第一附属医院普外科,陕西 西安 710061)
Author(s):
YAO Lan1GUO Fei1SONG Li1LIAO Xinhua2
(1.Operating Room of the First Affiliated Hospital of Xi’an Jiaotong University,Xi’an 710061,China;2.Department of General Surgery,the First Affiliated Hospital of Xi’an Jiaotong University,Xi’an 710061,China)
关键词:
结直肠癌肠梗阻脂多糖结合蛋白可溶性CD14亚型乳酸脱氢酶预测价值
Keywords:
Colorectal cancerIntestinal obstructionLipopolysaccharide binding proteinPresepsinLactate dehydrogenasePredictive value
分类号:
R 735.3
DOI:
DOI:10.3969/j.issn.1000-7377.2025.06.015
文献标志码:
A
摘要:
目的:分析血清脂多糖结合蛋白(LBP)、可溶性白细胞分化抗原14亚型(presepsin)、乳酸脱氢酶(LDH)联合检测对结直肠癌术后肠梗阻发生的预测价值。方法:选择因结直肠癌进行手术治疗的患者154例为研究对象,依据术后2周内是否发生肠梗阻分为肠梗阻组(32例)和非肠梗阻组(122例)。比较两组血清LBP、presepsin、LDH水平;分析结直肠癌患者术后发生肠梗阻的影响因素;评估血清LBP、presepsin、LDH联合检测对患者术后发生肠梗阻的预测价值。结果:两组肿瘤部位、结直肠癌临床分期比较差异有统计学意义(均P<0.05)。与非肠梗阻组比较,肠梗阻组血清LBP、presepsin、LDH水平显著升高(均P<0.05)。临床分期Ⅲ-Ⅳ期以及血清LBP、presepsin、LDH水平升高是术后发生肠梗阻的危险因素(均P<0.05)。血清LBP、presepsin、LDH水平均对术后发生肠梗阻具有一定的预测价值,且三项联合的预测价值高于单项(均P<0.05)。结论:结直肠癌术后肠梗阻患者血清LBP、presepsin、LDH水平均升高,三项联合检测能够有效预测结直肠癌患者术后肠梗阻的发生。
Abstract:
Objective:To analyze the predictive value of combined detection of serum lipopolysaccharide binding protein (LBP),presepsin and lactate dehydrogenase (LDH) for intestinal obstruction after colorectal cancer surgery.Methods:A total of 154 patients undergoing surgical treatment for colorectal cancer were selected as the study subjects,32 patients were included into the intestinal obstruction group and 122 patients were included into the non-intestinal obstruction group based on whether intestinal obstruction occurred within 2 weeks after surgery.The serum levels of LBP,presepsin and LDH were compared between the two groups.The influencing factors of postoperative intestinal obstruction in patients with colorectal cancer were analyzed.The predictive value of combined detection of serum LBP,presepsin and LDH for postoperative intestinal obstruction was evaluated.Results:There were significant differences in tumor location and clinical stage of colorectal cancer between the two groups (all P<0.05).Compared with the non-intestinal obstruction group,the serum levels of LBP,presepsin and LDH in the intestinal obstruction group were significantly increased (all P<0.05).Clinical stage Ⅲ-Ⅳ and elevated serum LBP,presepsin and LDH levels were risk factors for postoperative intestinal obstruction (all P<0.05).Serum LBP,presepsin and LDH levels all had certain predictive value for postoperative intestinal obstruction,and the predictive value of the combination of the three was higher than that of each single item (all P<0.05).Conclusion:The serum levels of LBP,presepsin and LDH are increased in patients with intestinal obstruction after colorectal cancer surgery.The combined detection of the three indicators can effectively predict the occurrence of intestinal obstruction after colorectal cancer surgery.

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备注/Memo

备注/Memo:
陕西省重点研发计划项目(2021SF-123)
更新日期/Last Update: 2025-06-04