[1]赵国安,陈书桐,陈宇洋,等.铁死亡在急性肺损伤中的研究进展[J].陕西医学杂志,2025,54(4):571-574.[doi:DOI:10.3969/j.issn.1000-7377.2025.04.027]
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铁死亡在急性肺损伤中的研究进展
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
54
期数:
2025年4期
页码:
571-574
栏目:
综 述
出版日期:
2025-04-05

文章信息/Info

作者:
赵国安陈书桐陈宇洋付宣雨林 松王天阳
(齐齐哈尔医学院,黑龙江 齐齐哈尔 161006)
关键词:
铁死亡 急性肺损伤 活性氧 炎症 脂质过氧化物
分类号:
R 563
DOI:
DOI:10.3969/j.issn.1000-7377.2025.04.027
文献标志码:
A
摘要:
铁死亡(Ferroptosis)作为一种新近发现的程序性细胞死亡方式,显著区别于传统的凋亡与坏死途径。其核心在于铁依赖性的脂质过氧化物(LPO)的累积,这一过程会引发膜脂质的过氧化损伤及线粒体的形态与功能衰退。通过铁螯合剂与抗氧化剂等干预手段,铁死亡过程可被有效抑制,进一步证实了其机制的关键性。急性肺损伤(ALI)则是一种由多重因素触发的病理状态,主要涉及肺泡上皮细胞与毛细血管内皮细胞的广泛损害,临床表现为肺间质与肺泡的弥漫性水肿,且重症患者的死亡风险极高。感染性因素如细菌感染是导致ALI的主要病因之一,而脂多糖(LPS)是细菌感染导致ALI的主要物质。尽管ALI的发病机制尚不完全清楚,但炎症反应与活性氧(ROS)的过度生成已被广泛认为是该疾病进展中的关键因素。研究显示,铁死亡在ALI的发生发展中发挥了重要作用。综上所述,现围绕铁死亡发生机制及其相关调节因子,深入探讨铁死亡在ALI疾病方面的研究进展。

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备注/Memo

备注/Memo:
[基金项目]黑龙江省自然科学基金联合引导项目(LH2021H124)
更新日期/Last Update: 2025-04-07