[1]刘维伟,王翠敏,刘平安,等.糖尿病足感染患者血清CXC趋化因子配体10和可溶性髓系细胞触发受体-1水平与病情、治疗效果的关系[J].陕西医学杂志,2025,54(3):349-353.[doi:DOI:10.3969/j.issn.1000-7377.2025.03.012]
　LIU Weiwei,WANG Cuimin,LIU Ping'an,et al.Relationship between serum CXCL10,sTREM-1 levels and disease condition,therapeutic efficacy in patients with diabetic foot infection[J].,2025,54(3):349-353.[doi:DOI:10.3969/j.issn.1000-7377.2025.03.012]
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糖尿病足感染患者血清CXC趋化因子配体10和可溶性髓系细胞触发受体-1水平与病情、治疗效果的关系
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
54
期数:
2025年3期
页码:
349-353
栏目:
临床研究
出版日期:
2025-03-05

文章信息/Info

Title:
Relationship between serum CXCL10,sTREM-1 levels and disease condition,therapeutic efficacy in patients with diabetic foot infection
作者:
刘维伟1; 王翠敏2; 刘平安3; 殷 苹1; 樊玉珠4
(1.石家庄市中医院检验科,河北 石家庄 050051; 2.石家庄市中医院脉管科,河北 石家庄 050051; 3.石家庄市中医院放射科,河北 石家庄 050051; 4.石家庄市中医院内分泌一科,河北 石家庄 050051)
Author(s):
LIU Weiwei1; WANG Cuimin2; LIU Ping'an3; YIN Ping1; FAN Yuzhu4
(1.Department of Laboratory,Shijiazhuang Hospital of Traditional Chinese Medicine,Shijiazhuang 050051,China; 2.Department of Vascular,Shijiazhuang Hospital of Traditional Chinese Medicine,Shijiazhuang 050051,China; 3.Department of Radiology,Shijiazhuang Hospital of Traditional Chinese Medicine,Shijiazhuang 050051,China; 4.The First Department of Endocrinology,Shijiazhuang Hospital of Traditional Chinese Medicine,Shijiazhuang 050051,China)
关键词:
糖尿病足感染;  CXC趋化因子配体10;  可溶性髓系细胞触发受体-1;  感染;  病情;  治疗效果
Keywords:
Diabetic foot infection;  CXC chemokine ligand 10;  Soluble triggering receptor expressed on myeloid cells-1;  Infect;  Disease condition;  Therapeutic efficacy
分类号:
R 587.2
DOI:
DOI:10.3969/j.issn.1000-7377.2025.03.012
文献标志码:
A
摘要:
目的:探讨糖尿病足感染(DFI)患者血清CXC趋化因子配体10(CXCL10)和可溶性髓系细胞触发受体-1(sTREM-1)水平与病情、治疗效果的关系。方法:选取DFI患者72例为DFI组,选取同期糖尿病足(DF)患者75例为DF组。收集患者临床资料,酶联免疫吸附法(ELISA)检测血清CXCL10、sTREM-1水平。根据ISDA分级对DFI患者感染程度进行分级,分为轻度组(28例)、中度组(31例)、重度组(13例)。根据治疗效果将DFI患者分为治疗有效组(52例)与治疗无效组(20例)。分析影响DFI患者治疗效果的因素及CXCL10、sTREM-1检测对治疗效果的预测价值。结果:DFI组血清CXCL10、sTREM-1水平显著高于DF组(均P<0.05)。重度组血清CXCL10、sTREM-1水平显著高于中度组与轻度组,中度组患者血清CXCL10、sTREM-1水平显著高于轻度组(均P<0.05)。治疗无效组血清CXCL10、sTREM-1水平显著高于治疗有效组(均P<0.05)。CXCL10、sTREM-1水平升高是DFI患者治疗无效的危险因素(均P<0.05)。血清CXCL10、sTREM-1水平联合检测预测患者治疗无效的效能优于单独单项检测(均P<0.05)。结论:DFI患者血清CXCL10、sTREM-1水平升高,与病情、治疗效果密切相关。
Abstract:
Objective:To investigate the relationship between the levels of serum CXC chemokine ligand 10(CXCL10),soluble triggering receptor expressed on myeloid cells-1(sTREM-1)and the disease condition,therapeutic efficacy in patients with diabetic foot infection(DFI).Methods:A total of 72 patients with DFI were included as DFI group,and 75 patients with diabetic foot(DF)were as DF group in the same period.Clinical data were collected,and ELISA was applied to detect serum CXCL10 and sTREM-1 levels.According to the ISDA classification of infection severity,DFI patients were separated into mild group(28 cases),moderate group(31 cases)and severe group(13 cases).According to the treatment effect,DFI patients were separated into effective treatment group(52 cases)and ineffective treatment group(20 cases).The factors that affected the treatment efficacy of DFI patients and the predictive value of serum CXCL10 and sTREM-1 levels for treatment efficacy were analyzed.Results:The serum levels of CXCL10 and sTREM-1 in the DFI group were obviously higher than those in the DF group(all P<0.05).The serum levels of CXCL10 and sTREM-1 in the severe group were obviously higher than those in the moderate and mild groups,while the serum levels of CXCL10 and sTREM-1 in the moderate group were obviously higher than those in the mild group(all P<0.05).The serum levels of CXCL10 and sTREM-1 in the ineffective group were obviously higher than those in the effective group(all P<0.05).Elevated levels of CXCL10 and sTREM-1 were risk factors for ineffective treatment in DFI patients(all P<0.05).Serum CXCL10 and sTREM-1 levels combined predict efficacy of treatment futility in patients that were better than diagnosis alone(all P<0.05).Conclusion:The serum CXCL10 and STREM-1 levels were higher,which were closely related to the disease and therapeutic efficacy.

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备注/Memo

备注/Memo:
[基金项目]河北省中医药管理局科研计划项目(2024367)
更新日期/Last Update: 2025-03-05