[1]严兆华,方醒艺,姚美华,等.外泌体和免疫细胞在子宫内膜异位症发生与发展中的作用研究进展[J].陕西医学杂志,2025,54(2):285-288.[doi:DOI:10.3969/j.issn.1000-7377.2025.02.030]
　YAN Zhaohua,FANG Xingyi,YAO Meihua,et al.Research progress on the role of exosomes and immune cells in the occurrence and development of endometriosis[J].,2025,54(2):285-288.[doi:DOI:10.3969/j.issn.1000-7377.2025.02.030]
点击复制

外泌体和免疫细胞在子宫内膜异位症发生与发展中的作用研究进展
分享到：

《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
54
期数:
2025年2期
页码:
285-288
栏目:
综 述
出版日期:
2025-02-05

文章信息/Info

Title:
Research progress on the role of exosomes and immune cells in the occurrence and development of endometriosis
作者:
严兆华1; 方醒艺2; 姚美华2; 张国玲2; 马天仲2
(1.广东医科大学附属医院妇产医学中心,广东 湛江 524001; 2.广东医科大学附属医院生殖医学中心,广东 湛江 524001)
Author(s):
YAN Zhaohua1; FANG Xingyi2; YAO Meihua2; ZHANG Guoling2; MA Tianzhong2
(1.Obstetrics and Gynecology Medical Center,Affiliated Hospital of Guangdong Medical University,Zhanjiang 524001,China; 2.Reproductive Medicine Center,Affiliated Hospital of Guangdong Medical University,Zhanjiang 524001,China)
关键词:
子宫内膜异位症;  外泌体;  免疫细胞;  发病机制;  免疫失衡
Keywords:
Endometriosis;  Exosomes;  Immune cells;  Pathogenesis;  Immune imbalance
分类号:
R 711.71
DOI:
DOI:10.3969/j.issn.1000-7377.2025.02.030
文献标志码:
A
摘要:
子宫内膜异位症(EMs)是生育期妇女的多发病、常见病,主要症状表现为疼痛及不育,异位内膜可侵犯全身多个部位,对妇女健康和生活质量产生严重影响。目前,暂无明确的EMs发病机制,主流学说包括经血逆流学说、诱导学说等。外泌体是一种具有磷脂双分子层的囊泡结构,来源于晚期核内体。研究发现,外泌体与EMs的发生和发展有关。EMs被认为是一种免疫失调的复杂疾病,患者大部分免疫细胞功能均存在异常。现对外泌体和免疫细胞在EMs发生和发展中的作用进行综述,为EMs的治疗提供一定的理论依据和参考。
Abstract:
Endometriosis(EMs)is a common and frequent disease among women of reproductive age,primarily characterized by pain and infertility.Ectopic endometrial tissue can invade multiple areas throughout the body,severely impacting women's health and quality of life.Currently,there is no clear understanding of the pathogenesis of EMs,with mainstream theories including retrograde menstruation and induction theories,among others.Exosomes are vesicular structures with a phospholipid bilayer,originating from late endosomes.Studies have found that exosomes are associated with the occurrence and development of EMs.EMs is considered a complex disease of immune dysregulation,with most immune cells in patients showing functional abnormalities.This article reviews the role of exosomes and immune cells in the occurrence and development of EMs,providing a theoretical basis and reference for the treatment of EMs.

参考文献/References:

[1] ELLIS K,MEADOR A,PONNAMPALAM A,et al.Survey of general practitioner perspectives on endometriosis diagnosis,referrals,management and guidelines in New Zealand[J].Health Expect,2024,27(5):e70015.
[2] ZENG H,WANG Y.Effects of various controlled ovarian hyperstimulation protocols and surgery on pregnancy outcomes in women with endometriosis[J].Gynecol Endocrinol,2024,40(1):2381504.
[3] 李冰冰,丁美琪,孙新慧,等.脂肪间充质干细胞外泌体对人子宫内膜异位症细胞纤维化形成的影响[J].药物评价研究,2024,47(9):2032-2040.
[4] 季镓锜,袁铭,唐羽霞,等.外泌体在子宫内膜异位症发病机制中研究进展[J].浙江中西医结合杂志,2024,34(5):482-486.
[5] 苏宁,李海霞,王维,等.子宫内膜异位症患者卵泡液外泌体miRNA谱差异及生信分析[J].广州医药,2024,55(3):324-330.
[6] 郁俐,沈青青,刘特,等.外泌体在卵母细胞发育及相关疾病中的研究进展[J].中华生殖与避孕杂志,2023,43(9):982-987.
[7] 张妍,郭凯悦,关小米,等.外泌体在子宫内膜异位症发生发展中的研究进展[J].中国计划生育和妇产科,2023,15(8):12-15.
[8] 夏璐,万贵平,张真真.旁分泌效应在子宫内膜异位症中的研究进展[J].现代妇产科进展,2023,32(6):468-471.
[9] 杨凯悦,王慧华.外泌体在子宫内膜异位症中的研究进展[J].世界最新医学信息文摘,2022,22(59):5-10.
[10] 毛海燕,陈元欢,武权生,等.加味少腹逐瘀汤对子宫内膜异位症寒凝血瘀证盆腔疼痛神经血管生成的影响[J].中国实验方剂学杂志,2022,28(12):141-147.
[11] 辛欣,连方,吴海萃.外泌体在子宫内膜异位症中的研究进展[J].中华生殖与避孕杂志,2021,41(10):915-919.
[12] 叶宁珍,赵绍杰,王高莹,等.外泌体miRNA在妇产科疾病中的研究进展[J].南京医科大学学报(自然科学版),2021,41(6):932-936.
[13] 王礼贤,胡月阳,李琰,等.子宫内膜间质细胞来源外泌体miRNA表达谱的差异分析[J].安徽医科大学学报,2020,55(11):1801-1805.
[14] CONSUL N,HABER H R,MOVILLA P R,et al.Continued improvement to imaging diagnosis and treatment triage of endometriosis:The role of the multi-disciplinary conference[J].Curr Probl Diagn Radiol,2024,53(6):663-669.
[15] SMYK J M,DANIELECKA Z,KOTOWSKA M,et al.Cardiovascular risks and endothelial dysfunction in reproductive-age women with endometriosis[J].Sci Rep,2024,14(1):24127.
[16] 李小康,雷文卿,薛春艳,等.子宫内膜异位症患者血清lncRNA PVT1和HIF-1α水平及临床意义[J].分子诊断与治疗杂志,2024,16(8):1591-1595.
[17] 彭静,苏同生,杨赟璐,等.针灸调节子宫内膜异位症不孕免疫失衡作用机制研究进展[J].世界中医药,2023,18(22):3283-3288.
[18] 路畅,谢成茂,魏薇.子宫内膜异位症铁死亡相关诊断基因及治疗靶点的遗传分析[J].现代妇产科进展,2023,32(3):188-195.
[19] 姚军,张丽姣,花茂方.自然杀伤细胞在子宫内膜异位症免疫调节中的研究进展[J].国际免疫学杂志,2023,46(1):98-102.
[20] 来庆玲,汤小晗,卢美松.免疫细胞在子宫内膜异位症发病机制中的作用研究新进展[J].中国计划生育和妇产科,2022,14(9):41-43.
[21] 王迎瑶,陈友国.子宫内膜异位症所致不孕的免疫学研究进展[J].大连医科大学学报,2022,44(4):362-365,369.
[22] 黄从想,张仙土,李群锋.人类白细胞抗原血管内皮生长因子在子宫内膜异位症中的表达[J].中国药物与临床,2019,19(17):2974-2976.
[23] 刘人杰.子宫内膜异位症免疫调节治疗的研究进展[J].贵州医药,2022,46(2):184-186.
[24] 魏佳慧,吴玉梅.腹腔免疫微环境改变与子宫内膜异位症相关性研究进展[J].医学综述,2022,28(11):2183-2187.
[25] YANG X,JIANG L,XU Y.HSD11B1 overexpression in dendritic cells and stromal cells relates to endometriosis by inhibiting dendritic cell proliferation and maturation[J].Gynecol Endocrinol,2024,40(1):2411607.
[26] KOBAYASHI H,IMANAKA S,YOSHIMOTO C,et al.Rethinking the pathogenesis of endometriosis:Complex interactions of genomic,epigenetic,and environmental factors[J].J Obstet Gynaecol Res,2024,50(10):1771-1784.
[27] 陈璐,林莉,朱小兰.巨噬细胞极化在子宫内膜异位症中的研究进展[J].实用医学杂志,2022,38(21):2751-2754.
[28] 张文娟,李江,林陶秀,等.基于阴阳学说探讨巨噬细胞M1/M2稳态失调与子宫内膜异位症的相关性[J].环球中医药,2022,15(11):2175-2179.
[29] 尹小瑞,王莹东,柳铮男,等.巨噬细胞在卵巢生理和病理情况下作用的研究进展[J].东南大学学报(医学版),2021,40(1):119-124.
[30] 梁梦珊,朱耀魁.子宫内膜异位症发病机制的研究现状[J].中华妇幼临床医学杂志:电子版,2021,17(2):138-141.
[31] 杜愿,转黎,李云秀,等.淋巴细胞相关免疫微环境在子宫内膜异位症中的研究进展[J].重庆医学,2022,51(19):3379-3384.
[32] 王礼贤,胡月阳,李琰,等.芯片技术分析卵巢子宫内膜异位症外泌体microRNA表达差异[J].重庆医科大学学报,2019,44(7):885-890.
[33] 吉秀家,黄灿灿,毛海燕,等.子宫内膜异位症纤维化小鼠模型的建立和表型验证[J].中国兽医杂志,2023,59(10):22-30.
[34] 武琳琳,张衡,李世杰,等.条件性子宫细胞剔除的研究[J].中国畜牧兽医,2020,47(4):1140-1147.
[35] 高航,陈洁,鲍青悦,等.微创手术联合GnRH-a治疗EMs不孕患者疗效及对卵巢功能、炎症因子及妊娠结局影响[J].中国计划生育学杂志,2020,28(3):328-331.

相似文献/References:

[1]高 扬,朱 艳△.子宫内膜异位症合并不孕患者血清中基质金属蛋白酶-9、基质金属蛋白酶抑制剂-1、血管内皮生长因子可溶性受体、胰岛素生长因子-1、单核细胞趋化蛋白-1表达水平及临床意义[J].陕西医学杂志,2020,49(4):462.
　GAO Yang,ZHU Yan..Expression of MMP-9,TIMP-1,sflt-1,IGF-1 and MCP-1 in serum of endometriosis patients with infertility and its clinical significance[J].,2020,49(2):462.
[2]王新香,张朝红.血清性激素和胰岛素水平对子宫内膜异位症合并不孕症的预测价值[J].陕西医学杂志,2021,50(1):41.[doi:DOI:10.3969/j.issn.1000-7377.2021.01.010]
[3]刘 丹,梁新新.育龄期子宫内膜异位症合并不孕症患者临床特征及腹腔镜术后辅助生殖妊娠结局影响因素分析[J].陕西医学杂志,2021,50(4):409.[doi:DOI:10.3969/j.issn.1000-7377.2021.04.006]
　LIU Dan,LIANG Xinxin.Clinical characteristics of endometriosis patients with infertility in childbearing age and influencing factors of assisted reproductive pregnancy outcome after laparoscopic surgery[J].,2021,50(2):409.[doi:DOI:10.3969/j.issn.1000-7377.2021.04.006]
[4]马 骞,朱 军,蔡梦珊,等.基于exoRBase外泌体数据库结直肠癌竞争性内源RNA网络构建及富集分析[J].陕西医学杂志,2021,50(7):797.[doi:DOI:10.3969/j.issn.1000-7377.2021.07.007]
　MA Qian,ZHU Jun,CAI Mengshan,et al.Construction and enrichment analysis of competing endogenous RNA network for colorectal cancer based on the exoRBase database[J].,2021,50(2):797.[doi:DOI:10.3969/j.issn.1000-7377.2021.07.007]
[5]崔 凯,白峻峰,支亚男,等.外泌体微小RNA-23a对非小细胞肺癌血管生成的影响及机制研究[J].陕西医学杂志,2021,50(9):1048.[doi:DOI:10.3969/j.issn.1000-7377.2021.09.002]
　CUI Kai,BAI Junfeng,ZHI Ya'nan,et al.Effect of exosome miR-23a on angiogenesis in NSCLC and its mechanism[J].,2021,50(2):1048.[doi:DOI:10.3969/j.issn.1000-7377.2021.09.002]
[6]白治苗,刘玉锋,郭玉琳,等.骨桥蛋白基因沉默对子宫内膜异位症患者在位内膜细胞侵袭性的影响[J].陕西医学杂志,2022,51(6):668.[doi:DOI:10.3969/j.issn.1000-7377.2022.06.006]
　BAI Zhimiao,LIU Yufeng,GUO Yulin,et al.Effect of osteopontin gene silencing on invasiveness of eutopic endometrial cells in patients with endometriosis[J].,2022,51(2):668.[doi:DOI:10.3969/j.issn.1000-7377.2022.06.006]
[7]邢 佳,曾娅莉,邓建军.肺结核患者血清外泌体中差异表达的微小RNAs及其功能分析[J].陕西医学杂志,2023,52(7):906.[doi:DOI:10.3969/j.issn.1000-7377.2023.07.030]
　XING Jia,ZENG Yali,DENG Jianjun.Differentially expressed miRNAs in serum exosomes from patients with pulmonary tuberculosis and their functional analysis[J].,2023,52(2):906.[doi:DOI:10.3969/j.issn.1000-7377.2023.07.030]
[8]孙利娟,黄香平,张多多,等.沉默miR-6771-3p通过靶向AXIN2/Wnt信号通路调控异位子宫内膜间质细胞增殖和迁移实验研究[J].陕西医学杂志,2023,52(11):1468.[doi:DOI:10.3969/j.issn.1000-7377.2023.11.004]
　SUN Lijuan,HUANG Xiangping,ZHANG Duoduo,et al.Silencing miR-6771-3p regulates the proliferation and migration of ectopic endometrial stromal cells by targeting AXIN2/Wnt signaling pathway[J].,2023,52(2):1468.[doi:DOI:10.3969/j.issn.1000-7377.2023.11.004]
[9]唐 剑,陈双华,何 凌.骨髓间充质干细胞来源外泌体对大鼠脊髓损伤的改善作用及对脊髓组织胞浆型磷脂酶A2、水通道蛋白4和水通道蛋白9的影响实验研究[J].陕西医学杂志,2023,52(12):1654.[doi:DOI:10.3969/j.issn.1000-7377.2023.12.006]
　TANG Jian,CHEN Shuanghua,HE Ling.Improvement effects of BMSCs-derived exosomes on spinal cord injury in rats and its effects on cytosolic phospholipase A2,aquaporin 4 and aquaporin 9 in spinal cord tissues[J].,2023,52(2):1654.[doi:DOI:10.3969/j.issn.1000-7377.2023.12.006]
[10]秦 汉,于长鸿,王继宏.间充质干细胞治疗跟腱病机制研究进展[J].陕西医学杂志,2024,(9):1290.[doi:DOI:10.3969/j.issn.1000-7377.2024.09.030]
　QIN Han,YU Changhong,WANG Jihong.Research progress on mechanisms of mesenchymal stem cell therapy for achilles tendinopathy[J].,2024,(2):1290.[doi:DOI:10.3969/j.issn.1000-7377.2024.09.030]

备注/Memo

备注/Memo:
[基金项目]国家自然科学基金资助项目(81300484); 广东省基础与应用基础研究基金资助项目(2022A1515010849)
更新日期/Last Update: 2025-02-04