[1]刘 冰,霍会永,赵聪慧,等.数字减影血管造影引导下神经介入取栓术对急性脑梗死患者血管内皮功能及血清血栓素 A2、CXC趋化因子配体16水平的影响[J].陕西医学杂志,2025,54(1):88-92.[doi:DOI:10.3969/j.issn.1000-7377.2025.01.017]
　LIU Bing,HUO Huiyong,ZHAO Conghui,et al.Effects of asd-guided interventional thrombophilia on vascular endothelial function and serum levels of TXA2 and CXCL16 in patients with acute cerebral infarction[J].,2025,54(1):88-92.[doi:DOI:10.3969/j.issn.1000-7377.2025.01.017]
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数字减影血管造影引导下神经介入取栓术对急性脑梗死患者血管内皮功能及血清血栓素 A2、CXC趋化因子配体16水平的影响
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
54
期数:
2025年1期
页码:
88-92
栏目:
临床研究
出版日期:
2025-01-05

文章信息/Info

Title:
Effects of asd-guided interventional thrombophilia on vascular endothelial function and serum levels of TXA2 and CXCL16 in patients with acute cerebral infarction
作者:
刘 冰; 霍会永; 赵聪慧; 刘晓霞; 刘佳佳; 张文超
(邯郸市中心医院神经内科,河北 邯郸 056001)
Author(s):
LIU Bing; HUO Huiyong; ZHAO Conghui; LIU Xiaoxia; LIU Jiajia; ZHANG Wenchao
(Department of Neurology,Handan Central Hospital,Handan 056001,China)
关键词:
脑梗死;  数字减影血管造影引导下神经介入取栓术;  血管内皮功能;  血栓素 A2;  CXC 趋化因子配体16;  神经功能
Keywords:
Cerebral infarction;  DSA guided nerve interventional thrombectomy;  Vascular endothelial function;  TXA2;  CXCL16;  Neurological function
分类号:
R 743
DOI:
DOI:10.3969/j.issn.1000-7377.2025.01.017
文献标志码:
A
摘要:
目的:探讨数字减影血管造影(DSA)引导下神经介入取栓术对急性脑梗死患者血管内皮功能及血栓素 A2(TXA2)、CXC 趋化因子配体16(CXCL16)水平的影响。方法:选择急性脑梗死患者122例,通过治疗计划不同分为观察组(n=68)与对照组(n=54)。对照组方案为阿替普酶(rt-PA)静脉溶栓,观察组为DSA引导下的神经介入取栓术; 比较两组患者临床疗效、血清CXCL16、TXA2水平、神经功能和日常生活能力、内皮细胞功能、凝血及血管再通情况。结果:观察组、对照组总有效率分别为91.17%、70.37%(均P<0.05)。经治疗,观察组血清CXCL16、TXA2水平与对照组比较明显降低(均P<0.05)。观察组患者美国国立卫生研究院卒中评分量表(NIHSS)、改良Rankin量表(mRS)评分与对照组比较明显降低(均P<0.05),日常生活能力指数(BI)评分有所提高(P<0.05)。治疗后,观察组血清内皮素-1(ET-1)、TXB2水平明显降低,NO水平升高(均P<0.05),与对照组比较,观察组患者PV、FIB、PAR水平明显降低(均P<0.05)。观察组、对照组血管再通率分别为85.29%、62.96%(均P<0.05)。结论:急性脑梗死患者应用DSA引导下神经介入取栓术可以快速清除病变血管血栓,恢复血流灌注,血管内皮功能改善,降低血清TXA2、CXCL16水平。
Abstract:
Objective:To determine the effects of lower nerve intervention thrombotomy guided by subtraction digital angiography(DSA)on vascular endothelial function and levels of thrombothrombin A2(TXA2)and chemokine-cxc-16 ligande(CXCL16)in patients with acute cerebral infarction.Methods:Sixty-one patients with acute cerebral infarction were selected and assigned to the control group(n=27)and observation group(n=34)depending on the treatment.The control protocol was venous thrombosis with alteplase(rt-Pa)and the observation group,interventional neurological thrombosis guided by DSA; Comparison of levels of CXCL16,TXA2,neurological function and daily living ability,clinical efficacy,endothelial cell function,blood clotting and vascular recollection between the two groups.Results:The total effective rate of observation group and control group was 91.17% and 70.37%,respectively(all P<0.05).Observation group was treated by plasma CXCL16,TXA2 levels significantly decreased compared with control group(all P<0.05).The NIHSS and mRS Scores in the observation group were significantly lower than those in the control group(all P<0.05),while BI scores were increased(P<0.05).After treatment,the serum ET-1 and TXB2 levels in the observation group were significantly decreased,and the level of NO was increased(all P<0.05).Compared with the control group,the levels of PV,FIB and PAR in the observation group were significantly decreased after treatment(all P<0.05).The recanalization rates of the observation group and the control group were 85.26% and 62.96%,respectively(all P<0.05).Conclusion:DSA guided lower nerve intervention thrombotomy in patients with acute cerebral infarction can rapidly eliminate thrombosis from the diseased vessel,restore blood flow perfusion,restore vascular endothelial function and reduce serum levels of TXA2 and CXCL16,which is appropriate for clinical use.

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备注/Memo

备注/Memo:
基金项目:河北省邯郸市科学技术研究与发展计划项目(19422083009-22)
更新日期/Last Update: 2025-01-06