[1]左玮玮,郭泓江.颈动脉CTA评估颈动脉粥样硬化狭窄程度及与血清脂蛋白相关磷脂酶A2、血管生成素样蛋白8水平的相关性分析[J].陕西医学杂志,2025,54(1):62-66.[doi:DOI:10.3969/j.issn.1000-7377.2025.01.011]
　ZUO Weiwei,GUO Hongjiang.Carotid artery CTA assessed the degree of carotid atherosclerosis stenosis and its correlation with serum Lp-PLA2 and ANCPTL8 levels[J].,2025,54(1):62-66.[doi:DOI:10.3969/j.issn.1000-7377.2025.01.011]
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颈动脉CTA评估颈动脉粥样硬化狭窄程度及与血清脂蛋白相关磷脂酶A2、血管生成素样蛋白8水平的相关性分析
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
54
期数:
2025年1期
页码:
62-66
栏目:
临床研究
出版日期:
2025-01-05

文章信息/Info

Title:
Carotid artery CTA assessed the degree of carotid atherosclerosis stenosis and its correlation with serum Lp-PLA2 and ANCPTL8 levels
作者:
左玮玮1; 2; 郭泓江3
(1.邢台医学院附属医院核医学科,河北 邢台 054000; 2.邢台市中心医院核医学科,河北 邢台 054000; 3.河北医科大学第四医院体检中心,河北 石家庄 050000)
Author(s):
ZUO Weiwei; GUO Hongjiang
(Department of Nuclear Medicine,Affiliated Hospital of Xingtai Medical College,Xingtai 054000,China)
关键词:
颈动脉粥样硬化;  计算机断层扫描血管成像;  脂蛋白相关磷脂酶A2;  血管生成素样蛋白8;  颈动脉狭窄;  相关性
Keywords:
Carotid atherosclerosis;  Computed tomography angiography;  Lipoprotein-associated phospholipase A2;  Angiopoietin-likeprotein8;  Carotid stenosis;  Correlation
分类号:
R 543.4
DOI:
DOI:10.3969/j.issn.1000-7377.2025.01.011
文献标志码:
A
摘要:
目的:探讨颈动脉计算机断层扫描血管成像(CTA)评估颈动脉粥样硬化(CAS)狭窄程度及与血清脂蛋白相关磷脂酶A2(Lp-PLA2)、血管生成素样蛋白8(ANCPTL8)水平的相关性。方法:选取颈动脉粥样硬化合并颈动脉狭窄患者155例为合并组,根据病情严重程度分为轻度组(n=50)、中度组(n=38)和重度组(n=67),另选92例单纯颈动脉粥样硬化患者为未合并组。比较不同病情严重程度颈动脉狭窄患者血清Lp-PLA2、ANCPTL8水平,多因素Logistic回归分析颈动脉粥样硬化患者合并颈动脉狭窄的危险因素,以数字减影血管造影(DSA)为金标准,分析CTA检测颈动脉狭窄程度的评估价值。结果:与DSA检测结果比较,CTA检测结果无统计学差异(P>0.05)。与轻度组比较,中度组和重度组患者血清Lp-PLA2、ANCPTL8水平显著升高(均P<0.05),与中度组患者比较,重度组患者血清Lp-PLA2、ANCPTL8水平显著升高(均P<0.05)。两组年龄、性别、吸烟史、高脂血症、血清高密度脂蛋白、低密度脂蛋白水平之间比较无统计学差异(均P>0.05),合并组患者高血压、糖尿病、冠心病患者占比、血清Lp-PLA2、ANCPTL8水平显著高于未合并组(均P<0.05)。高血压、糖尿病、冠心病、高血清Lp-PLA2、ANCPTL8水平是颈动脉粥样硬化患者合并颈动脉狭窄的危险因素(均P<0.05)。血清Lp-PLA2、ANCPTL8水平与患者颈动脉狭窄程度具有较高相关性,且与其呈正相关(均P<0.05)。结论:颈动脉CTA检测对颈动脉狭窄程度具有较高的评估价值,且血清Lp-PLA2、ANCPTL8水平与患者颈动脉狭窄程度具有较高相关性。高血压、糖尿病、冠心病、高血清Lp-PLA2、ANCPTL8水平是颈动脉粥样硬化患者合并颈动脉狭窄的危险因素。
Abstract:
Objective:To investigate the correlation of carotid artery computed tomography angiography(CTA)to the degree of carotid atherosclerosis stenosis and the levels of serum lipoprotein-associated phospholipase A2(Lp-PLA2)and angiopoietin-like protein 8(ANCPTL8).Methods:A total of 155 patients with carotid atherosclerosis combined with carotid artery stenosis were selected as the combined group,and divided into mild group(n=50),moderate group(n=38)and severe group(n=67)according to the severity of the disease,and 92 patients with simple carotid atherosclerosis were selected as the non-combined group.Serum Lp-PLA2 and ANCPTL8 levels in patients with carotid artery stenosis of different severity were compared,and the risk factors of carotid artery stenosis in patients with carotid atherosclerosis were analyzed by multivariate Logistic regression.Digital subtraction angiography(DSA)was used as the gold standard to analyze the evaluation value of CTA in detecting the degree of carotid artery stenosis.Results:Compared with DSA,CTA showed no significant difference(P>0.05).Compared with mild group,the serum levels of Lp-PLA2 and ANCPTL8 in moderate group and severe group were significantly increased(all P<0.05); compared with moderate group,the serum levels of Lp-PLA2 and ANCPTL8 in severe group were significantly increased(all P<0.05).There were no significant differences in age,sex,smoking history,hyperlipidemia,serum high density lipoprotein and low density lipoprotein levels between the two groups(all P>0.05).The proportion of patients with hypertension,diabetes,coronary heart disease,serum Lp-PLA2 and ANCPTL8 levels in the combined group were significantly higher than those in the non-combined group(all P<0.05).Hypertension,diabetes,coronary heart disease,high serum Lp-PLA2 and ANCPTL8 levels were risk factors for carotid artery stenosis in patients with carotid atherosclerosis(all P<0.05).Serum Lp-PLA2 and ANCPTL8 levels were highly correlated with the degree of carotid artery stenosis,and were negatively correlated with them(all P<0.05).Conclusion:Carotid CTA has a high value in evaluating the degree of carotid artery stenosis,and serum Lp-PLA2 and ANCPTL8 levels are highly correlated with the degree of carotid artery stenosis.Hypertension,diabetes,coronary heart disease,high serum Lp-PLA2 and ANCPTL8 levels are risk factors for carotid artery stenosis in patients with carotid atherosclerosis.

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备注/Memo

备注/Memo:
基金项目:河北省卫生健康委科研项目(20201122)
更新日期/Last Update: 2025-01-06