[1]曾胜澜,梁健芬,邢俊娥,等.铁死亡在药物性肝损伤中的作用机制及治疗研究进展[J].陕西医学杂志,2024,(12):1718-1720，1725.[doi:DOI:10.3969/j.issn.1000-7377.2024.12.027]
　ZENG Shenglan,LIANG Jianfen,XING Jun'e,et al.Research progress on mechanism and treatment of ferroptosis in drug-induced liver injury[J].,2024,(12):1718-1720，1725.[doi:DOI:10.3969/j.issn.1000-7377.2024.12.027]
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铁死亡在药物性肝损伤中的作用机制及治疗研究进展
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
期数:
2024年12期
页码:
1718-1720，1725
栏目:
综 述
出版日期:
2024-12-05

文章信息/Info

Title:
Research progress on mechanism and treatment of ferroptosis in drug-induced liver injury
作者:
曾胜澜1; 梁健芬1; 邢俊娥1; KHAMSAEN Suebsak2(泰国); 毛德文1
(1.广西中医药大学第一附属医院,广西 南宁 530023; 2.帕尧大学,泰国 帕尧 56000)
Author(s):
ZENG Shenglan; LIANG Jianfen; XING Jun'e; KHAMSAEN Suebsak; MAO Dewen
(First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine,Nanning 530023,China)
关键词:
药物性肝损伤;  急性肝衰竭;  铁死亡;  铁过载;  谷胱甘肽过氧化物酶4;  氧化应激
Keywords:
Drug-induced liver injury;  Acute liver failure;  Ferroptosis;  Iron overload;  Glutathione peroxidase 4;  Oxidative stress
分类号:
R 575
DOI:
DOI:10.3969/j.issn.1000-7377.2024.12.027
文献标志码:
A
摘要:
铁死亡是一种不同于细胞凋亡、细胞焦亡、坏死和自噬的细胞死亡非典型形式,其发生机制与细胞膜上的磷脂分子被过氧化破坏有关。急性肝衰竭(ALF)病死率高且医疗花费大,而药物性肝损伤(DILI)是引起ALF的重要原因。近年研究发现,与铁死亡有关的氧化还原失衡、铁过载和脂质过氧化在DILI中发挥作用。现对铁死亡在DILI中的作用机制进行综述,并总结目前一些基于铁死亡治疗DILI的研究进展。
Abstract:
Ferroptosis is an atypical form of cell death different from apoptosis,pyroptosis,necrosis and autophagy,and its mechanism is related to the destruction of phospholipid molecules on the cell membrane by peroxidation.Acute liver failure(ALF)has a high mortality rate and high medical cost,and drug-induced liver injury(DILI)is an important cause of ALF.Recent studies have found that redox imbalance,iron overload and lipid peroxidation related to ferroptosis play a role in DILI.This article reviews the mechanism of ferroptosis in DILI,and summarizes some current research progress of ferroptosis-based therapy for DILI.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金资助项目(82274434); 国家中医药管理局高水平中医药重点学科建设项目(ZYYZDXK-2023166)
更新日期/Last Update: 2024-12-05