[1]贺 兰,王 健,杜燕燕.缺血缺氧性脑病新生儿血清可溶性细胞间黏附分子1、肌酸激酶同工酶、胰岛素样生长因子1检测及其与病情严重程度和预后关系研究[J].陕西医学杂志,2024,(12):1689-1692,1698.[doi:DOI:10.3969/j.issn.1000-7377.2024.12.021]
　HE Lan,WANG Jian,DU Yanyan.Serum sICAM-1,CK-MB,IGF-1 in neonates with hypoxic-ischemic encephalopathy and their relationship with disease severity and prognosis[J].,2024,(12):1689-1692,1698.[doi:DOI:10.3969/j.issn.1000-7377.2024.12.021]
点击复制

缺血缺氧性脑病新生儿血清可溶性细胞间黏附分子1、肌酸激酶同工酶、胰岛素样生长因子1检测及其与病情严重程度和预后关系研究
分享到：

《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
期数:
2024年12期
页码:
1689-1692,1698
栏目:
临床检验
出版日期:
2024-12-05

文章信息/Info

Title:
Serum sICAM-1,CK-MB,IGF-1 in neonates with hypoxic-ischemic encephalopathy and their relationship with disease severity and prognosis
作者:
贺 兰; 王 健; 杜燕燕
(北京清华长庚医院儿科,北京 102218)
Author(s):
HE Lan; WANG Jian; DU Yanyan
(Department of Pediatrics,Beijing Tsinghua Changgung Hospital,Beijing 102218,China)
关键词:
缺血缺氧性脑病;  可溶性细胞间黏附分子1;  肌酸激酶同工酶;  胰岛素样生长因子1;  预后;  影响因素;  新生儿
Keywords:
Hypoxic-ischemic encephalopathy;  Soluble intercellular adhesion molecule-1;  Creatine kinase-MB;  Insulin-1ike growth factor 1;  Prognosis;  Influencing factor;  Neonates
分类号:
R 722.1
DOI:
DOI:10.3969/j.issn.1000-7377.2024.12.021
文献标志码:
A
摘要:
目的:探讨缺血缺氧性脑病(HIE)新生儿血清可溶性细胞间黏附分子1(sICAM-1)、肌酸激酶同工酶(CK-MB)、胰岛素样生长因子1(IGF-1)与病情严重程度及预后的关系。方法:选择HIE患儿125例为HIE组,另选择健康新生儿112例为对照组,比较两组血清sICAM-1、CK-MB、IGF-1水平。根据疾病严重程度将HIE患儿分为轻、中、重度组,分析HIE患儿血清sICAM-1、CK-MB、IGF-1水平与病情严重程度的相关性。根据随访结果将HIE患儿分为预后良好组和预后不良组,比较两组临床资料。Logistic回归分析HIE患儿预后不良的影响因素。结果:HIE组血清sICAM-1、CK-MB水平高于对照组,血清IGF-1水平低于对照组(均P<0.05)。HIE患儿血清sICAM-1、CK-MB水平随病情严重程度的增加而升高,IGF-1水平则随病情严重程度的增加而降低(均P<0.05)。预后不良组患儿病情重度占比、血清sICAM-1和CK-MB水平高于预后良好组,开始治疗日龄晚于预后良好组,Apgar评分和血清IGF-1水平低于预后良好组(均P<0.05)。HIE患儿预后危险因素包括开始治疗日龄>3 d、疾病重度、高水平sICAM-1和CK-MB、低水平IGF-1(均P<0.05)。HIE患儿疾病严重程度、开始治疗日龄与血清sICAM-1、CK-MB水平呈正相关,与血清IGF-1水平呈负相关(均P<0.05)。结论:HIE患儿血清sICAM-1、CK-MB水平升高,IGF-1水平下降。HIE患儿疾病严重程度与血清sICAM-1、CK-MB水平呈正相关,与IGF-1呈负相关。
Abstract:
Objective:To investigate the serum soluble intercellular adhesion molecule-1(sICAM-1),creatine kinase isoenzyme(CK-MB),insulin-like growth factor 1(IGF-1)in neonatal with hypoxic-ischemic encephalopathy(HIE)and their relationship disease severity and prognosis.Methods:A total of 125 neonates with HIE were enrolled as the HIE group,and 112 healthy neonates were enrolled as the control group,and the serum levels of sICAM-1,CK-MB,and IGF-1 were compared between the two groups.The neonates with HIE were divided into mild,moderate,and severe groups according to the severity of the disease,and the correlations of serum levels of sICAM-1,CK-MB and IGF-1 with the severity of the disease were analyzed.According to the follow-up results,the HIE neonates were divided into good prognosis group and poor prognosis group,and the clinical data were compared between the two groups.Logistic regression was used to analyze the influencing factors for poor prognosis in neonates with HIE.Results:Serum sICAM-1 and CK-MB levels in HIE group were higher than those in control group,and serum IGF-1 levels was lower than those in control group(all P<0.05).The levels of sICAM-1 and CK-MB increased with the severity of HIE,while the level of IGF-1 decreased with the severity of HIE(all P<0.05).Compared with the good prognosis group,the poor prognosis group had a higher proportion of children with severe disease,higher serum sICAM-1 and CK-MB levels,a later age at the start of treatment,and a lower Apgar score and serum IGF-1 level(all P<0.05).The risk factors for prognosis in neonates with HIE included age >3 days at the beginning of treatment,severe disease,high levels of sICAM-1 and CK-MB,and low level of IGF-1(all P<0.05).The severity of HIE and the age at the beginning of treatment were positively correlated with the serum levels of sICAM-1 and CK-MB,and negatively correlated with the serum level of IGF-1(all P<0.05).Conclusion:The levels of serum sICAM-1 and CK-MB in HIE neonates increased,while IGF-1 decreased.The severity of disease in HIE neonates was positively correlated with the levels of serum sICAM-1 and CK-MB,and negatively correlated with IGF-1.

参考文献/References:

[1] LUGLI L,GARETTI E,GOFFREDO B M,et al.Continuous fentanyl infusion in newborns with hypoxic-ischemic encephalopathy treated with therapeutic hypothermia:Background,aims,and study protocol for time-concentration profiles[J].Biomedicines,2023,11(9):2395.
[2] 马昕,纪婷.血清可溶性细胞间黏附分子1和凝血指标检测对卵巢子宫内膜异位囊肿患者腹腔镜卵巢囊肿剔除术后复发的预测价值[J].陕西医学杂志,2023,52(2):208-211,216.
[3] 宋奕,肖蕾萍,张嘉玲.血清sLOX-1、VILIP-1和脑红蛋白在新生儿缺氧缺血性脑病病情和预后判断中的价值[J].检验医学与临床,2023,20(1):67-71.
[4] 张国城,金晓星,王晓菲,等.脾神经刺激对大鼠心肌缺血再灌注后心电活动异常的保护作用[J].中华老年心脑血管病杂志,2022,24(11):1193-1196.
[5] 黄亮星,贺东红.脑出血患者神经内分泌因子表达水平与脑出血量及认知功能相关性研究[J].陕西医学杂志,2020,49(4):439-441,509.
[6] 干烨,郑迎爱,李双,等.特发性中枢性性早熟女童的血清胰岛素样生长因子-1肌酐尿酸与黄体生成素骨龄的关系[J].中国妇幼保健,2023,38(13):2382-2385.
[7] 母得志.新生儿缺氧缺血性脑病的诊断和治疗[J].实用儿科临床杂志,2011,26(14):1144-1147.
[8] 张鹏.缺氧缺血性脑病新生儿血清髓鞘碱性蛋白、神经元特异性烯醇化酶水平与病情严重程度相关性分析及预后评估价值[J].陕西医学杂志,2021,50(6):720-722.
[9] KORF J M,MCCULLOUGH L D,CARETTI V.A narrative review on treatment strategies for neonatal hypoxic ischemic encephalopathy[J].Transl Pediatr,2023,12(8):1552-1571.
[10] MALAN R,VANDERLINDE J,KRITZINGER A,et al.Evolution of feeding and developmental outcomes in infants with moderate hypoxic-ischemic encephalopathy:A pilot study[J].Neonatal Netw,2023,42(5):264-275.
[11] 王春南,张瑜.电针结合振动训练对缺氧缺血性脑病患儿运动功能的影响[J].陕西中医,2023,44(8):1145-1149.
[12] 欧阳福连,黄郁波,黄涛,等.咪达唑仑对新生缺氧缺血性脑病小鼠脑皮质神经元凋亡的影响[J].中国临床药理学杂志,2023,39(6):834-838.
[13] 王树国.参附注射液治疗新生儿缺氧缺血性脑病36例[J].陕西中医,2012,33(11):1457-1458.
[14] 田鹏,张沥文,杨莎.缺氧缺血性脑病新生儿血清CK-MB、cTnI水平与NABA评分的相关性[J].中国计划生育学杂志,2022,30(12):2852-2855.
[15] 乔正梅,葛君琍,张雷.C-反应蛋白、肌酸激酶、肌酸激酶同工酶、乳酸脱氢酶及神经元特异性烯醇化酶在新生儿缺氧缺血性脑病中的临床价值[J].中国卫生检验杂志,2022,32(2):230-233.
[16] 张婷,徐水亮.血清sLOX-1、cTnI及CK-MB检测在缺氧缺血性脑病诊断中的价值[J].国际检验医学杂志,2021,42(10):1223-1227.
[17] BALTAZAR-LARA R,ÁVILA-MENDOZA J,MARTÍNEZ-MORENO C G,et al.Neuroprotective effects of growth hormone(GH)and insulin-like growth factor type 1(IGF-1)after hypoxic-ischemic injury in chicken cerebellar cell cultures[J].Int J Mol Sci,2020,22(1):256.
[18] 卢艳辉,刘振奎,王雅莉,等.血清胰岛素样生长因子1、白介素17、白介素23水平与新生儿缺氧缺血性脑病患儿疾病严重程度及预后的关系研究[J].实用心脑肺血管病杂志,2022,30(4):67-71.
[19] 刘莉,陈光耀,张玉,等.神经节苷脂联合胞磷胆碱及亚低温疗法对新生儿缺氧缺血性脑病血清VEGF、sICAM-1水平及预后的影响[J].医学综述,2020,26(4):823-828.
[20] XING Z,ZHEN T,JIE F,et al.Early toll-like receptor 4 inhibition improves immune dysfunction in the hippocampus after hypoxic-ischemic brain damage[J].Int J Med Sci,2022,19(1):142-151.
[21] 黄玉维,冯金明,韦清华.新生儿缺氧缺血性脑病血清8-OHDG、NSE、sICAM-1、ADM水平变化与病情的关系[J].山东医药,2018,58(18):64-66.
[22] 雷玉琳,冯琴,熊伶俐,等.新生儿缺血缺氧性脑病患儿cTnI、CK-MB、IL-6及hs-CRP表达水平及意义[J].西部医学,2023,35(5):745-749.
[23] 武楠,陈婷,林丽星.缺氧缺血性脑病中胰岛素样生长因子-1的研究进展[J].临床儿科杂志,2017,35(11):868-872.
[24] 王聪颖,张帆.宫内窘迫新生儿发生缺氧缺血性脑病风险的列线图预测模型建立[J].中华全科医学,2023,21(3):369-373..
[25] 陈晓.新生儿缺氧缺血性脑病的亚低温治疗临床疗效及预后危险因素分析[D].济南:山东大学,2020.
[26] 刘克宇,王会民,张重梅.血清可溶性细胞间黏附分子-1和神经元特异性烯醇化酶检测在新生儿缺氧缺血性脑病的诊断价值[J].国际检验医学杂志,2011,32(12):1330-1331.

相似文献/References:

[1]马 昕,纪 婷.血清可溶性细胞间黏附分子1和凝血指标检测对卵巢子宫内膜异位囊肿患者腹腔镜卵巢囊肿剔除术后复发的预测价值[J].陕西医学杂志,2023,52(2):208.[doi:DOI:10.3969/j.issn.1000-7377.2023.02.021]
　MA Xin,JI Ting.Predictive value of serum soluble intercellular adhesion molecule 1 and coagulation indexes for recurrence after laparoscopic ovarian cyst excision in patients with ovarian endometriosis[J].,2023,52(12):208.[doi:DOI:10.3969/j.issn.1000-7377.2023.02.021]

备注/Memo

备注/Memo:
基金项目:北京市自然科学基金资助项目(2023FH1369)
更新日期/Last Update: 2024-12-05