[1]施 静,潘溢丹.慢性阻塞性肺疾病急性加重患者高分辨率CT肺血管参数与肺功能、病情严重程度及预后相关性分析[J].陕西医学杂志,2024,(12):1649-1653.[doi:DOI:10.3969/j.issn.1000-7377.2024.12.012]
　SHI Jing,PAN Yidan.Correlation between pulmonary vascular parameters on HRCT and lung function,disease severity and prognosis in patients with AECOPD[J].,2024,(12):1649-1653.[doi:DOI:10.3969/j.issn.1000-7377.2024.12.012]
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慢性阻塞性肺疾病急性加重患者高分辨率CT肺血管参数与肺功能、病情严重程度及预后相关性分析
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
期数:
2024年12期
页码:
1649-1653
栏目:
临床研究
出版日期:
2024-12-05

文章信息/Info

Title:
Correlation between pulmonary vascular parameters on HRCT and lung function,disease severity and prognosis in patients with AECOPD
作者:
施 静1; 潘溢丹2
(1.上海健康医学院附属崇明医院呼吸内科,上海 202150; 2.上海健康医学院附属崇明医院神经内科,上海 202150)
Author(s):
SHI Jing; PAN Yidan
(Department of Respiratory Medicine,Chongming Hospital,Shanghai Health Medical College,Shanghai 202150,China)
关键词:
慢性阻塞性肺疾病急性加重;  高分辨率CT;  肺血管参数;  肺功能;  疾病严重程度;  预后
Keywords:
AECOPD;  HRCT;  Pulmonary vascular parameters;  Pulmonary function;  Severity of illness;  Prognosis
分类号:
R 563.9
DOI:
DOI:10.3969/j.issn.1000-7377.2024.12.012
文献标志码:
A
摘要:
目的:探讨慢性阻塞性肺疾病急性加重(AECOPD)患者高分辨率CT(HRCT)肺血管参数与肺功能、病情严重程度及预后的相关性。方法:选取AECOPD患者138例为AECOPD组,按疾病严重程度分组轻度组(48例)、中度组(44例)和重度组(46例)。另选同期体检健康者42例为对照组。比较AECOPD组与对照组HRCT肺血管参数和肺功能指标,分析HRCT肺血管参数与肺功能的相关性。比较不同病情程度AECOPD患者HRCT肺血管参数。随访1年后,根据预后情况分为预后不良组和预后良好组,分析AECOPD患者预后影响因素。结果:与对照组比较,AECOPD组横截面<5 mm2肺小血管面积百分比(%CSA<5)、用力肺活量(FVC)、第1秒用力呼气容积(FEV1)及FEV1/FVC下降,主肺动脉直径与主动脉直径比值(PA/A)增加(均P<0.05)。%CSA<5与肺功能指标呈正相关,PA/A与肺功能指标呈负相关(均P<0.05)。轻度组与中度组%CSA<5高于重度组(均P<0.05),但两组比较无统计学差异(P>0.05)。与预后良好组比较,预后不良组重度病情占比和PA/A升高,%CSA<5降低(均P<0.05)。AECOPD患者预后不良的危险因素包括重度AECOPD、低%CSA<5和高PA/A(均P<0.05)。结论:AECOPD患者肺血管参数与肺功能和病情严重程度密切相关,且肺血管参数能够有效评估患者预后情况。
Abstract:
Objective:To investigate the correlation between pulmonary vascular parameters on HRCT and pulmonary function,disease severity and prognosis in AECOPD patients.Methods:A total of 138 patients with AECOPD were selected as the AECOPD group,and were divided into mild group(48 cases),moderate group(44 cases)and severe group(46 cases)according to the severity of the disease.A total of 42 healthy people in the same period were selected as the control group.The pulmonary vascular parameters on HRCT and pulmonary function indexes were compared between two groups,and the correlation between pulmonary vascular parameters on HRCT and pulmonary function was analyzed.The pulmonary vascular parameters on HRCT of AECOPD patients with different severity of disease were compared.After 1 year of follow-up,AECOPD patients were divided into poor prognosis group and good prognosis group,and the prognostic factors of AECOPD patients were analyzed.Results:Compared with the control group,%CSA <5,FVC,FEV1 and FEV1/FVC were decreased,and PA/A was increased in the AECOPD group(all P<0.05).%CSA <5 was positively correlated with pulmonary function indexes,and PA/A was negatively correlated with pulmonary function indexes(all P<0.05).Compared with severe group,the%CSA <5 in mild group and moderate group was higher(all P<0.05).There was no significant difference in PA/A among the three groups(P>0.05).Compared with the good prognosis group,the proportion of severe disease and PA/A were increased,and%CSA <5 was decreased in the poor prognosis group(all P<0.05).The risk factors for poor prognosis in AECOPD patients included severe AECOPD,low%CSA <5,and high PA/A(all P<0.05).Conclusion:Pulmonary vascular parameters and lung function in patients with AECOPD and disease severity are closely related,and pulmonary vascular parameters can effectively evaluate patients prognosis.

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备注/Memo

备注/Memo:
基金项目:上海市卫生健康委员会医学科学研究课题(2020FH63)
更新日期/Last Update: 2024-12-05