[1]杨思瑜,曹春蕾,徐玉善,等.超声靶向微泡破坏技术在肝细胞癌基因治疗中的应用研究进展[J].陕西医学杂志,2024,(11):1567-1570,1575.[doi:DOI:10.3969/j.issn.1000-7377.2024.11.028]
　YANG Siyu,CAO Chunlei,XU Yushan,et al.Research progress on the application of ultrasound-targeted microbubble destruction technology in gene therapy for hepatocellular carcinoma[J].,2024,(11):1567-1570,1575.[doi:DOI:10.3969/j.issn.1000-7377.2024.11.028]
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超声靶向微泡破坏技术在肝细胞癌基因治疗中的应用研究进展
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
期数:
2024年11期
页码:
1567-1570,1575
栏目:
综 述
出版日期:
2024-11-05

文章信息/Info

Title:
Research progress on the application of ultrasound-targeted microbubble destruction technology in gene therapy for hepatocellular carcinoma
作者:
杨思瑜1; 曹春蕾2; 徐玉善3; 王玉锦4; 冯仕杰5; 郑晨宏4
(1.昆明医科大学第三附属医院放射科,云南 昆明 650118; 2.解放军总医院京南医疗区丰北桥门诊部,北京 100071; 3.昆明医科大学第一附属医院内分泌科,云南 昆明 650032; 4.解放军总医院第三医学中心心内科,北京 100039; 5.昆明医科大学第二附属医院风湿免疫科,云南 昆明 650033)
Author(s):
YANG Siyu; CAO Chunlei; XU Yushan; WANG Yujin; FENG Shijie; ZHENG Chenhong
(Department of Radiology,the Third Affiliated Hospital of Kunming Medical University,Kunming 650118,China)
关键词:
肝细胞癌;  超声靶向微泡破坏技术;  基因治疗;  载体;  微泡;  转染
Keywords:
Hepatocellular carcinoma;  Ultrasound-targeted microbubble destruction technology;  Gene therapy;  Vectors;  Microbubble;  Transfection
分类号:
R 735.7
DOI:
DOI:10.3969/j.issn.1000-7377.2024.11.028
文献标志码:
A
摘要:
肝细胞癌(HCC)是常见的恶性肿瘤之一,基因治疗作为一种新型治疗手段,已经在HCC治疗中展现出巨大的潜力。近年来,超声靶向微泡破坏(UTMD)技术作为一种新型的基因递送技术,在HCC基因治疗中取得了一些重要的研究进展,从UTMD介导自杀基因、基因沉默、增加基因表达以及联合其他载体治疗等方面进行了深入研究,进而为HCC的诊断和治疗提供可靠的方法。因此,现对UTMD技术在HCC基因治疗中的应用进行综述。
Abstract:
Hepatocellular carcinoma(HCC)is one of the common malignant tumors,and gene therapy,as a novel therapeutic tool,has shown great potential in the treatment of HCC.In recent years,ultrasound-targeted microbubble disruption(UTMD)technology,as a novel gene delivery technology,has made some important research progress in HCC gene therapy,which has been studied in depth from various aspects,such as UTMD-mediated suicide genes,gene silencing,increase of gene expression,and combined with other vector therapies,which in turn provides a reliable method for the diagnosis and treatment of HCC.Therefore,this review summarizes the application of UTMD technology in HCC gene therapy.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金资助项目(82160125); 云南省科技厅科技计划项目(202201AY070001-041,202201AY070001-168); 昆明医科大学研究生教育创新基金资助项目(2023S316); 昆明医科大学校级大学生创新性实验项目(2023CXD149,2023CXD194); 昆明医科大学科技创新团队建设项目(CXTD202106)
更新日期/Last Update: 2024-11-04