[1]冯敏娟,蔡东阁,李 虹.转录因子7-like 2在宫颈癌中表达水平及其与顺铂化疗敏感性关系研究[J].陕西医学杂志,2024,(10):1335-1339.[doi:DOI:10.3969/j.issn.1000-7377.2024.10.008]
　FENG Minjuan,CAI Dongge,LI Hong.Expression level of transcription factor 7-like 2 in cervical cancer and its relationship with cisplatin chemotherapy sensitivity[J].,2024,(10):1335-1339.[doi:DOI:10.3969/j.issn.1000-7377.2024.10.008]
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转录因子7-like 2在宫颈癌中表达水平及其与顺铂化疗敏感性关系研究
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
期数:
2024年10期
页码:
1335-1339
栏目:
临床研究
出版日期:
2024-10-05

文章信息/Info

Title:
Expression level of transcription factor 7-like 2 in cervical cancer and its relationship with cisplatin chemotherapy sensitivity
作者:
冯敏娟1; 蔡东阁1; 李 虹2
(1.西安交通大学第二附属医院妇产科,陕西 西安 710004; 2陕西省人民医院妇产科,陕西 西安 710068)
Author(s):
FENG Minjuan; CAI Dongge; LI Hong
(Department of Obstetrics and Gynecology,the Second Affiliated Hospital of Xi'an Jiaotong University,Xi'an 710004,China)
关键词:
宫颈癌;  化疗;  顺铂;  转录因子7-like 2;  预后;  耐药性
Keywords:
Cervical cancer;  Chemotherapy;  Cisplatin;  Transcription factor 7-like 2;  Prognosis;  Drug resistance
分类号:
R 737.33
DOI:
DOI:10.3969/j.issn.1000-7377.2024.10.008
文献标志码:
A
摘要:
目的:探究转录因子7-like 2(TCF7L2)在宫颈癌患者中表达水平及其与顺铂化疗敏感性的相关性。方法:收集68例宫颈癌患者(观察组)和68例体检正常者(对照组)为研究对象。留取两组晨起静脉血样用于血清TCF7L2和β-catenin表达水平测定。分析血清中TCF7L2和β-catenin与患者临床特征及顺铂化疗敏感性的关系。结果:观察组患者血清TCF7L2和β-catenin表达水平显著高于对照组(均P<0.05)。观察组患者FIGO分期Ⅳa期、肿瘤低分化者血清中TCF7L2、β-catenin表达水平明显高于FIGO分期Ⅱb期、Ⅲ期和肿瘤高分化者,FIGO分期Ⅲ期明显高于FIGO分期Ⅱb期,出现淋巴转移者高于无淋巴转移者(均P<0.05); 同时顺铂化疗不敏感者血清TCF7L2、β-catenin表达水平明显高于敏感者(均P<0.05)。Logistic回归分析显示,血清中TCF7L2、β-catenin高表达是顺铂化疗不敏感的危险因素(均P<0.05)。结论:宫颈癌患者中TCF7L2异常高表达,且其高表达可能是导致患者顺铂化疗耐药的原因之一。
Abstract:
Objective:To investigate the expression level of transcription factor 7-like 2(TCF7L2)in patients with cervical cancer and its correlation with cisplatin chemotherapy sensitivity.Methods:A total of 68 patients with cervical cancer(observation group)and 68 patients with normal physical examination(control group)were collected as research objects.The expression levels of serum TCF7L2 and β-catenin were measured by morning venous blood samples from two groups.The relationship of serum TCF7L2 and β-catenin with clinical features and cisplatin sensitivity was analyzed.Results:The expression levels of serum TCF7L2 and β-catenin in observation group were significant in control group(all P<0.05).The serum expression levels of TCF7L2 and β-catenin in patients with FIGO stage Ⅳa and low tumor differentiation were significantly higher than those of patients with FIGO stage Ⅱb and Ⅲ and patients with high tumor differentiation,the expression levels of TCF7L2 and β-catenin in patients with FIGO stage Ⅲ were significantly higher than those of patients with FIGO stage Ⅱb,and the expression levels of TCF7L2 and β-catenin in patients with lymphatic metastasis were higher than those without lymphatic metastasis(all P<0.05).At the same time,the expression levels of TCF7L2 and β-catenin in patients with insensitive cisplatin chemotherapy were significantly higher than those of sensitive patients(all P<0.05).Logistic regression analysis showed that the high expressions of TCF7L2 and β-catenin were risk factor for insensitivity to cisplatin chemotherapy(all P<0.05).Conclusion:The abnormal high expression of TCF7L2 in patients with cervical cancer may be one of the reasons leading to cisplatin resistance.

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备注/Memo

备注/Memo:
基金项目:陕西省重点研发基金资助项目(2021SF-201)
更新日期/Last Update: 2024-10-08