[1]秦 汉,于长鸿,王继宏.间充质干细胞治疗跟腱病机制研究进展[J].陕西医学杂志,2024,(9):1290-1293.[doi:DOI:10.3969/j.issn.1000-7377.2024.09.030]
　QIN Han,YU Changhong,WANG Jihong.Research progress on mechanisms of mesenchymal stem cell therapy for achilles tendinopathy[J].,2024,(9):1290-1293.[doi:DOI:10.3969/j.issn.1000-7377.2024.09.030]
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间充质干细胞治疗跟腱病机制研究进展
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
期数:
2024年9期
页码:
1290-1293
栏目:
综 述
出版日期:
2024-09-05

文章信息/Info

Title:
Research progress on mechanisms of mesenchymal stem cell therapy for achilles tendinopathy
作者:
秦 汉1; 2; 于长鸿1; 2; 王继宏1
(1.内蒙古医科大学第二附属医院,内蒙古 呼和浩特 010010; 2.内蒙古医科大学,内蒙古 呼和浩特 010059)
Author(s):
QIN Han; YU Changhong; WANG Jihong
(The Second Affiliated Hospital of Inner Mongolia Medical University,Hohhot 010010,China)
关键词:
跟腱病;  间充质干细胞;  肌腱愈合;  外泌体;  免疫调节
Keywords:
Achilles tendinopathy;  Mesenchymal stem cells;  Tendon healing;  Exosomes;  Immunomodulation
分类号:
R 686.1
DOI:
DOI:10.3969/j.issn.1000-7377.2024.09.030
文献标志码:
A
摘要:
跟腱病(AT)无论是通过保守疗法还是手术疗法,都无法完全恢复跟腱的自然成分、组织构造和机械性能。间充质干细胞(MSCs)能够向肌腱组织方向分化,并通过发挥其免疫调控、细胞外基质重塑和血管生成的功能,促进肌腱的愈合。在肌腱的再生和修复过程中,MSCs起着关键的作用,并且具有广阔的应用潜力。现对MSCs在治疗AT中的作用机制进行阐述,以期为AT的研究和治疗提供思路。
Abstract:
Achilles tendinopathy(AT)is unable to fully restore the natural composition,organization,and mechanical properties of the Achilles tendon,either through conservative or surgical therapies.Mesenchymal stem cells(MSCs)are able to differentiate toward tendon tissue and promote tendon healing by exerting their functions of immunomodulation,extracellular matrix remodeling,and angiogenesis.MSCs play a key role in tendon regeneration and repair and have a broad potential for application.In this paper,we review the mechanism of action of MSCs in the treatment of AT and hope to shed light on AT research and treatment.

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备注/Memo

备注/Memo:
基金项目:内蒙古自然科学基金资助项目(2020MS08118); 内蒙古自治区科技计划项目(2021GG0206,2022YFSH0032); 内蒙古自治区公立医院高水平临床专科发展科技项目(2023SGGZ141)
更新日期/Last Update: 2024-09-04