[1]黄小刚,崔锦珠,覃小华,等.基于细胞焦亡探讨龙血竭治疗溃疡性结肠炎机制研究进展[J].陕西医学杂志,2024,(9):1282-1285.[doi:DOI:10.3969/j.issn.1000-7377.2024.09.028]
　HUANG Xiaogang,CUI Jinzhu,QIN Xiaohua,et al.Research progress on mechanism of dragon's blood in treatment of ulcerative colitis based on pyroptosis[J].,2024,(9):1282-1285.[doi:DOI:10.3969/j.issn.1000-7377.2024.09.028]
点击复制

基于细胞焦亡探讨龙血竭治疗溃疡性结肠炎机制研究进展
分享到：

《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
期数:
2024年9期
页码:
1282-1285
栏目:
综 述
出版日期:
2024-09-05

文章信息/Info

Title:
Research progress on mechanism of dragon's blood in treatment of ulcerative colitis based on pyroptosis
作者:
黄小刚1; 崔锦珠2; 覃小华2; 何晓金2; 段晓鑫2; 钟焕英2; 俞 渊2; 文亦磊2
(1.广西中医药大学,广西 南宁 530200; 2.广西中医药大学第一附属医院,广西 南宁 530023)
Author(s):
HUANG Xiaogang; CUI Jinzhu; QIN Xiaohua; HE Xiaojin; DUAN Xiaoxin; ZHONG Huanying; YU Yuan; WEN Yilei
(Guangxi University of Traditional Chinese Medicine,Nanning 530200,China)
关键词:
溃疡性结肠炎;  龙血竭;  细胞焦亡;  炎症;  肠道屏障;  分子机制
Keywords:
Ulcerative colitis;  Dragon's blood;  Pyroptosis;  Inflammation;  Intestinal barrier;  Molecular mechanisms
分类号:
R 574.62
DOI:
DOI:10.3969/j.issn.1000-7377.2024.09.028
文献标志码:
A
摘要:
溃疡性结肠炎(UC)是一种以黏膜免疫反应亢进和肠道上皮组织损伤为特征的慢性复发性炎症性疾病,临床上具有易复发、难痊愈、病程长、发病高等特点。UC发病机制复杂,病因尚不明确,当前常用药物不能有效缓解疾病的发展,存在一定的局限性。近年来越来越多的研究表明细胞焦亡在促进UC的发展中扮演着重要角色。细胞焦亡是一种促炎性程序性死亡,可造成结肠组织损伤难以愈合。中药龙血竭作为天然药用树脂,在防治UC上具有潜在价值,可通过多途径调控UC的发展。现基于细胞焦亡探讨龙血竭靶向治疗UC的分子机制,为龙血竭的临床应用提供理论依据。
Abstract:
Ulcerative colitis(UC)is a chronic relapsing inflammatory disease characterized by mucosal immune hyperresponsiveness and intestinal epithelial tissue damage.It is clinically characterized by easy recurrence,difficult recovery,long course of disease and high incidence.The pathogenesis of UC is complex,and the etiology is still unclear.At present,commonly used drugs cannot effectively alleviate the development of the disease,and there are certain limitations.In recent years,more and more studies have shown that pyroptosis plays an important role in promoting the development of UC.Pyroptosis is a pro-inflammatory programmed cell death that can cause colonic tissue damage to be difficult to heal.As a natural medicinal resin,dragon's blood has potential value in the prevention and treatment of UC,and can regulate the development of UC through multiple ways.This review intends to explore the molecular mechanism of dragon's blood in the targeted treatment of UC based on pyroptosis,and provide a theoretical basis for the clinical application of dragon's blood.

参考文献/References:

[1] 李竹林,赵瑛.高强度间歇性运动联合药物治疗溃疡性结肠炎疗效及对患者细胞因子水平影响研究[J].陕西医学杂志,2019,48(7):909-912.
[2] XU D,MA R,JU Y,et al.Cholesterol sulfate alleviates ulcerative colitis by promoting cholesterol biosynthesis in colonic epithelial cells[J].Nature Communications,2022,13(1):4428.
[3] ADAMS S M,BORNEMANN P H.Ulcerative colitis[J].American Family Physician,2013,87(10):699-705.
[4] KUCHARZIK T,KOLETZKO S,KANNENGIESSER K,et al.Ulcerative colitis-diagnostic and therapeutic algorithms[J].Deutsches Arzteblatt International,2020,117(33-34):564-574.
[5] 张玲,陈尧,尹航,等.布托啡诺对白细胞介素-1β诱导的关节软骨细胞焦亡的影响及机制研究[J].陕西医学杂志,2023,52(12):1665-1669,1674.
[6] DU T,GAO J,LI P,et al.Pyroptosis,metabolism,and tumor immune microenvironment[J].Clinical and Translational Medicine,2021,11(8):e492.
[7] ZHU F,LI S,GU Q,et al.APOL1 induces pyroptosis of fibroblasts through NLRP3/Caspase-1/GSDMD signaling pathway in ulcerative colitis[J].Journal of Inflammation Research,2023,16:6385-6396.
[8] 柳沛林,周军,魏海梁,等.细胞焦亡在溃疡性结肠炎中的作用及中药治疗进展[J].世界中西医结合杂志,2023,18(11):2327-2332.
[9] 莫钧茹,覃淼,朱素梅,等.基于药效团模型的龙血竭潜在降糖活性成分筛选[J].中草药,2022,53(15):4764-4772.
[10] 肖楠,刘珊,邓玉林,等.龙血竭防护模拟失重和辐射应激损伤研究进展[J].航天医学与医学工程,2021,34(5):392-398.
[11] LIU Y,MO L,LU H,et al.Dragon blood resin ameliorates steroid-induced osteonecrosis of femoral head through osteoclastic pathways[J].Frontiers in Cell and Developmental Biology,2023,11:1202888.
[12] 高文青.Pyrin炎症小体激活的分子机制与Gasdermin E介导的细胞焦亡的研究[D].北京:中国农业大学,2018.
[13] BERTHELOOT D,LATZ E,FRANKLIN B S.Necroptosis,pyroptosis and apoptosis:an intricate game of cell death[J].Cellular & Molecular Immunology,2021,18(5):1106-1121.
[14] MAN S M,KARKI R,KANNEGANTI T D.Molecular mechanisms and functions of pyroptosis,inflammatory caspases and inflammasomes in infectious diseases[J].Immunological Reviews,2017,277(1):61-75.
[15] 樊秋月,姜永红,陈一柳.清肺通络方通过胱天蛋白酶-1/Gasdermin D蛋白细胞焦亡途径对支原体肺炎小鼠的干预机制[J].陕西中医,2023,44(4):416-420.
[16] KOVACS S B,MIAO E A.Gasdermins:effectors of pyroptosis[J].Trends in Cell Biology,2017,27(9):673-684.
[17] ZHANG D,GE F,JI J,et al.β-sitosterol alleviates dextran sulfate sodium-induced experimental colitis via inhibition of NLRP3/Caspase-1/GSDMD-mediated pyroptosis[J].Frontiers in Pharmacology,2023,14:1218477.
[18] APAZA TICONA L,RUMBERO SÁNCHEZ Á,SÁNCHEZ SÁNCHEZ-CORRAL J,et al.Anti-inflammatory,pro-proliferative and antimicrobial potential of the compounds isolated from daemonorops draco(willd.)blume[J].Journal of Ethnopharmacology,2021,268:113668.
[19] 张越,宋美芳,李海涛,等.珍稀名贵药材龙血竭基原及同属植物的DNA条形码鉴定研究[J].中国中药杂志,2021,46(9):2173-2181.
[20] SUN J,LIU J N,FAN B,et al.Phenolic constituents,pharmacological activities,quality control,and metabolism of Dracaena species:A review[J].Journal of Ethnopharmacology,2019,244:112138.
[21] LANG G Z,LI C J,GAOHU T Y,et al.Bioactive flavonoid dimers from Chinese dragon's blood,the red resin of Dracaena cochinchinensis[J].Bioorganic Chemistry,2020,97:103659.
[22] LIU Y,ZHAO X,YAO R,et al.Dragon's blood from Dracaena worldwide:Species,traditional uses,phytochemistry and pharmacology[J].The American Journal of Chinese Medicine,2021,49(6):1315-1367.
[23] FAN J Y,YI T,SZE-TO C M,et al.A systematic review of the botanical,phytochemical and pharmacological profile of Dracaena cochinchinensis,a plant source of the ethnomedicine “dragon's blood”[J].Molecules(Basel,Switzerland),2014,19(7):10650-10669.
[24] LIN Y,XIONG W,XIAO S,et al.Pharmacoproteomics reveals the mechanism of Chinese dragon's blood in regulating the RSK/TSC2/mTOR/ribosome pathway in alleviation of DSS-induced acute ulcerative colitis[J].Journal of Ethnopharmacology,2020,263:113221.
[25] 刘瑶,张昕,刘玉娇,等.龙血竭降低尾吊模拟失重小鼠溃疡性结肠炎易感性[J].航天医学与医学工程,2021,34(5):354-360.
[26] 高辉.龙血竭散灌肠联合复方谷氨酰胺肠溶胶囊辅助治疗溃疡性结肠炎临床疗效观察[J].医学理论与实践,2023,36(8):1315-1317.
[27] 钱鑫,叶小峰,陶以理.益气清热解毒化瘀汤对溃疡性结肠炎的影响[J].长春中医药大学学报,2023,39(7):750-753.
[28] 叶可,李家新,梅芳.龙血竭散灌肠联合美沙拉嗪口服治疗溃疡性结肠炎的疗效评价[J].贵州医药,2017,41(7):709-711.
[29] OWCZAREK D,CIBOR D,GOWACKI M K,et al.Inflammatory bowel disease:Epidemiology,pathology and risk factors for hypercoagulability[J].World Journal of Gastroenterology,2014,20(1):53-63.
[30] ROLFES V,RIBEIRO L S,HAWWARI I,et al.Platelets fuel the inflammasome activation of innate immune cells[J].Cell Reports,2020,31(6):107615.
[31] JANKER L,SCHUSTER D,BORTEL P,et al.Multiomics-empowered deep phenotyping of ulcerative colitis identifies biomarker signatures reporting functional remission states[J].Journal of Crohn's & Colitis,2023,17(9):1514-1527.
[32] 王卫国.龙血竭散灌肠联合柳氮磺吡啶肠溶片治疗溃疡性结肠炎的临床研究[J].现代药物与临床,2018,33(6):1419-1423.
[33] 崔晓娟,奉建芳,陈颖,等.基于网络药理学分析龙血竭缓解实验性溃疡性结肠炎小鼠结肠黏膜损伤的作用机制[J].中草药,2019,50(16):3872-3879.
[34] LEVINSON T,WASSERMAN A.C-reactive protein velocity(CRPv)as a new biomarker for the early detection of acute infection/inflammation[J].International Journal of Molecular Sciences,2022,23(15):8100.
[35] UGUCCIONI M,GIONCHETTI P,ROBBIANI D F,et al.Increased expression of IP-10,IL-8,MCP-1,and MCP-3 in ulcerative colitis[J].The American Journal of Pathology,1999,155(2):331-336.
[36] LI K,YAO S,LIU S,et al.Genetic polymorphisms of interleukin 8 and risk of ulcerative colitis in the Chinese population[J].Clinica Chimica Acta,2009,405(1-2):30-34.
[37] HUANG B,LANG X,LI X.The role of IL-6/JAK2/STAT3 signaling pathway in cancers[J].Frontiers in Oncology,2022,12:1023177.
[38] TONG L,HAO H,ZHANG Z,et al.Milk-derived extracellular vesicles alleviate ulcerative colitis by regulating the gut immunity and reshaping the gut microbiota[J].Theranostics,2021,11(17):8570-8586.
[39] NAKASE H,SATO N,MIZUNO N,et al.The influence of cytokines on the complex pathology of ulcerative colitis[J].Autoimmunity Reviews,2022,21(3):103017.
[40] SCHAUFELBERGER H D,UHR M R,MCGUCKIN C,et al.Platelets in ulcerative colitis and Crohn's disease express functional interleukin-1 and interleukin-8 receptors[J].European Journal of Clinical Investigation,1994,24(10):656-663.
[41] UHLIG H H,SCHWERD T,KOLETZKO S,et al.The diagnostic approach to monogenic very early onset inflammatory bowel disease[J].Gastroenterology,2014,147(5):990-1007.e3.
[42] LARABI A,BARNICH N,NGUYEN H T T.New insights into the interplay between autophagy,gut microbiota and inflammatory responses in IBD[J].Autophagy,2020,16(1):38-51.
[43] 雷娜,雷兰平,吴容,等.芍药汤合龙血竭对溃疡性结肠炎大鼠的效应机制[J].中华中医药学刊,2023,41(9):53-58,266-267.
[44] ZHAO G,LI J,WANG J,et al.Aquaporin 3 and 8 are down-regulated in TNBS-induced rat colitis[J].Biochemical and Biophysical Research Communications,2014,443(1):161-166.
[45] 屈映,张书信,傅丽元,等.荆芥、防风对溃疡性结肠炎大鼠结肠黏膜AQP4和AQP8表达的影响[J].中国中药杂志,2020,45(15):3719-3725.

相似文献/References:

[1]李竹林,赵 瑛.高强度间歇性运动联合药物治疗溃疡性结肠炎疗效及对患者细胞因子水平影响研究*[J].陕西医学杂志,2019,(7):909.
　LI Zhulin,ZHAO Ying..Therapeutic effect of high-intensity intermittent exercise combined with drugs on ulcerative colitis and its effect on cytokine levels in patients[J].,2019,(9):909.
[2]陈玉林,董甲庆△.复方谷氨酰胺颗粒与肠内营养治疗溃疡性结肠炎临床研究[J].陕西医学杂志,2020,49(1):115.
　CHEN Yulin,DONG Jiaqing..Clinical study of compound glutamine granules and enteral nutrition in the treatment of ulcerative colitis[J].,2020,49(9):115.
[3]安 敏,高振军.美沙拉秦长期治疗对溃疡性结肠炎患者结肠黏膜癌相关基因表达的影响[J].陕西医学杂志,2021,50(4):485.[doi:DOI:10.3969/j.issn.1000-7377.2021.04.027]
[4]付 静,刘小婷,孙 婷,等.陕产七叶一枝花对小鼠溃疡性结肠炎的治疗作用及机制实验研究[J].陕西医学杂志,2024,(9):1161.[doi:DOI:10.3969/j.issn.1000-7377.2024.09.002]
　FU Jing,LIU Xiaoting,SUN Ting,et al.Therapeutic effect and mechanism of Paris polyphylla Sm. from Shaanxi on ulcerative colitis in mice[J].,2024,(9):1161.[doi:DOI:10.3969/j.issn.1000-7377.2024.09.002]
[5]池文婕,靳改玲,王佳敏,等.溃疡性结肠炎患者结肠黏膜组织叉头框转录因子M1、核因子-κΒ mRNA表达与病情严重程度关系研究[J].陕西医学杂志,2024,(9):1264.[doi:DOI:10.3969/j.issn.1000-7377.2024.09.024]
　CHI Wenjie,JIN Gailing,WANG Jiamin,et al.Relationship between expression of FoxM1,NF-κΒ mRNA in colonic mucosal tissue of patients with ulcerative colitis and severity of the disease[J].,2024,(9):1264.[doi:DOI:10.3969/j.issn.1000-7377.2024.09.024]
[6]袁芸菲,刘清娥,李 森,等.桔梗多糖经血小板衍生生长因子受体/血管内皮生长因子受体途径调控巨噬细胞对溃疡性结肠炎模型小鼠黏膜损伤的改善作用及机制研究[J].陕西医学杂志,2025,54(3):301.[doi:DOI:10.3969/j.issn.1000-7377.2025.03.003]
　YUAN Yunfei,LIU Qing'e,LI Sen,et al.Effect and mechanism of platycodon grandiflorum polysaccharides regulating macrophages through PDGF/VEGF receptor pathway in improving mucosal damage in ulcerative colitis model mice[J].,2025,54(9):301.[doi:DOI:10.3969/j.issn.1000-7377.2025.03.003]

备注/Memo

备注/Memo:
基金项目:国家自然科学基金资助项目(82160880); 广西壮族自治区卫生健康委员会自筹经费科研课题(Z20200288); 广西中医药大学“岐黄工程”高层次人才团队培育项目(202411)
更新日期/Last Update: 2024-09-04