[1]周 琴,黄丽琼,胡丽蓉,等.超声造影参数评估子宫内膜癌患者预后价值研究[J].陕西医学杂志,2024,(8):1055-1059.[doi:DOI:10.3969/j.issn.1000-7377.2024.08.010]
　ZHOU Qin,HUANG Liqiong,HU Lirong,et al.Value of contrast-enhanced ultrasound parameters in evaluating prognosis of patients with endometrial carcinoma[J].,2024,(8):1055-1059.[doi:DOI:10.3969/j.issn.1000-7377.2024.08.010]
点击复制

超声造影参数评估子宫内膜癌患者预后价值研究
分享到：

《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
期数:
2024年8期
页码:
1055-1059
栏目:
临床研究
出版日期:
2024-08-05

文章信息/Info

Title:
Value of contrast-enhanced ultrasound parameters in evaluating prognosis of patients with endometrial carcinoma
作者:
周 琴1; 黄丽琼1; 胡丽蓉1; 程 娟2; 万永祥2
(1.成都市第一人民医院 成都市中西医结合医院,四川 成都 610041; 2.重庆医药高等专科学校附属第一医院,重庆 400060)
Author(s):
ZHOU Qin; HUANG Liqiong; HU Lirong; CHENG Juan; WAN Yongxiang
(Chengdu First People's Hospital,Chengdu 610041,China)
关键词:
子宫内膜癌;  超声造影;  到达时间;  达峰时间;  平均通过时间;  峰值强度;  预后
Keywords:
Endometrial cancer;  Contrast-enhanced ultrasound;  Arrival time;  Time to peak;  Mean transit time;  Peak intensity;  Prognosis
分类号:
R 737.33
DOI:
DOI:10.3969/j.issn.1000-7377.2024.08.010
文献标志码:
A
摘要:
目的:探讨超声造影参数在子宫内膜癌患者预后评估中的价值。方法:选取接受全子宫切除术的子宫内膜癌患者96例。术后进行随访,观察患者腹腔内是否可疑转移病灶或新发病灶,记录复发及生存情况。根据术后有无复发将患者分为复发组(29例)和未复发组(67例)。根据术后生存情况将患者分为病死组(21例)和存活组(75例)。比较不同预后患者的临床资料与超声造影参数[到达时间(AT)、达峰时间(TTP)、平均通过时间(MTT)、峰值强度(PI)]。绘制受试者工作特征(ROC)曲线分析超声造影参数对子宫内膜癌患者复发及病死风险的预测价值。结果:与未复发组相比,复发组患者超声造影参数中AT、TTP较短,MTT较长、PI较高(均P<0.05)。AT、MTT、TTP、PI及四项联合预测子宫内膜癌患者复发风险的AUC分别为0.967、0.973、0.967、0.934、0.996,预测价值较高(均P<0.05)。与存活组相比,病死组患者超声造影参数中AT、TTP较短,MTT较长、PI较高(均P<0.05)。AT、MTT、TTP、PI及四项联合预测患者病死风险的AUC均>0.9,预测价值较高(均P<0.05)。结论:超声造影参数在评估子宫内膜癌患者预后方面具有重要价值,临床可依据患者个体病情差异,优先采取超声造影及时评估患者预后。
Abstract:
Objective:To investigate the value of contrast-enhanced ultrasound parameters in prognosis assessment of patients with endometrial cancer.Methods:A total of 96 patients with endometrial cancer underwent total hysterectomy were selected.Postoperative follow-up was performed to observe whether there were suspected metastases or new lesions in the abdominal cavity,and to record recurrence and survival.The patients were divided into recurrence group(29 cases)and non-recurrence group(67 cases)according to whether there was recurrence after surgery.According to postoperative survival,the patients were divided into death group(21 cases)and survival group(75 cases).The clinical data and contrast-enhanced ultrasound parameters of patients with different prognosis were compared.Receiver operating characteristic(ROC)curve was drawn to analyze the value of contrast-enhanced ultrasound parameters in predicting the risk of recurrence and death in patients with endometrial cancer.Results:Compared with the non-recurrence group,the arrival time(AT)and time to peak(TTP)parameters of contrast-enhanced ultrasound in the recurrence group were shorter,the mean transit time(MTT)was longer and the peak intensity(PI)was higher(all P<0.05).The AUC of AT,MTT,TTP,PI and the four combined predictions of recurrence risk in patients with endometrial cancer were 0.967,0.973,0.967,0.934,0.996,respectively,and the predictive value was high(all P<0.05).Compared with the survival group,the AT and TTP parameters of contrast-enhanced ultrasound in the dead group were shorter,the MTT was longer and the PI was higher(all P<0.05).The AUC of AT,MTT,TTP,PI and the four factors combined to predict the risk of death were all > 0.9,and the predictive value was high(all P<0.05).Conclusion:Ultrasonography parameters have important values in assessing the prognosis of endometrial cancer patients,and clinical priority can be given to ultrasonography for timely assessment of patients' prognosis according to their individual differences.

参考文献/References:

[1] BRETT M A,ATENAFU E G,SINGH N,et al.Equivalent survival of p53 mutated endometrial endometrioid carcinoma grade 3 and endometrial serous carcinoma[J].Int J Gynecol Pathol,2021,40(2):116-123.
[2] VICTOOR J,BORGHT S V,SPANS L,et al.Comprehensive immunomolecular profiling of endometrial carcinoma:A tertiary retrospective study[J].Gynecol Oncol,2021,162(3):694-701.
[3] 吕涛.实时超声弹性成像在子宫内膜癌浸润子宫肌层中的诊断价值——评《中国常见妇科恶性肿瘤诊治指南》[J].中国实验方剂学杂志,2023,29(14):238.
[4] PARK H J,JANG H Y,KIM S Y,et al.Non-enhanced magnetic resonance imaging as a surveillance tool for hepatocellular carcinoma:Comparison with ultrasound[J].J Hepatol,2020,72(4):718-724.
[5] TONG Y,SUN P,ZHOU J,et al.The association between ultrasound features and biological properties of invasive breast carcinoma is modified by age,tumor size,and the preoperative axilla status[J].J Ultrasound Med,2020,39(6):1125-1134.
[6] ERIKSSON L S E,EPSTEIN E,TESTA A C,et al.Ultrasound-based risk model for preoperative prediction of lymph-node metastases in women with endometrial cancer:Model-development study[J].Ultrasound Obstet Gynecol,2020,56(3):443-452.
[7] 张丹,李燕东,王茜,等.国际妇产科协会子宫内膜癌分期标准的修订与超声诊断的探讨[J].中国医学影像学杂志,2011,19(10):753-757.
[8] 贾丽.大蒜素对人子宫内膜癌Ishikawa细胞侵袭和迁移抑制作用的研究[J].陕西中医,2020,41(8):1042-1046.
[9] 孔维娜,李佳,赵淑华,等.代谢综合征在子宫内膜癌及其肿瘤微环境中的研究进展[J].陕西医学杂志,2023,52(11):1607-1611.
[10] LONG B,CLARKE M A,MORILLO A,et al.Ultrasound detection of endometrial cancer in women with postmenopausal bleeding:Systematic review and meta-analysis[J].Gynecol Oncol,2020,157(3):624-633.
[11] PEREONE M,BERGRAMINI A,TATEO S,et al.Transvaginal ultrasound in evaluation and follow-up of ovarian granulosa cell tumors[J].Int J Gynecol Cancer,2020,30(9):1384-1389.
[12] 臧萍萍,杨宗利.子宫内膜癌超声造影参数与盆腔淋巴结转移的相关性[J].中国医学影像技术,2020,36(12):1867-1871.
[13] 张丽,马哲洋.经腹联合经会阴超声在孕中期前置胎盘诊断中的应用价值[J].陕西中医,2021,42(1):93-94.
[14] 周璇,刘海静,白洁.经腹超声造影鉴别诊断子宫内膜病变价值及与微血管密度关系探讨[J].陕西医学杂志,2020,49(8):960-963.
[15] JIA H,YAN D,XIAO Q,et al.Correlations of ultrasonic features with severity of liver cancer and p16 expression in patients with liver cancer[J].Neoplasma,2019,66(1):149-154.
[16] FILIACI V L,MALLEN A R,LESLIE K K,et al.Mutated p53 portends improvement in outcomes when bevacizumab is combined with chemotherapy in advanced/recurrent endometrial cancer:An NRG oncology study[J].Gynecol Oncol,2021,161(1):113-121.
[17] ZHENG W,LI Q,ZOU X B,et al.Evaluation of contrast-enhanced US LI-RADS version 2017:Application on 2020 liver nodules in patients with hepatitis B infection[J].Radiology,2020,294(2):299-307.
[18] COBO-ABERT M,DIAZ-FEIJOO B,BRADBURY M,et al.Diagnostic performance of transvaginal ultrasound and magnetic resonance imaging for the preoperative evaluation of low-grade endometrioid endometrial carcinoma:A single-center prospective comparative study[J].Ultrasound Obstet Gynecol,2021,58(3):469-475.
[19] CHEN L,ZENG X,JI B,et al.Improving dynamic contrast-enhanced MRI of the lung using motion-weighted sparse reconstruction:Initial experiences in patients[J].Magn Reson Imaging,2020,68:36-44.
[20] CHEN L,ZENG X,WU Y,et al.A study of the correlation of perfusion parameters in high-resolution GRASP MRI with microvascular density in lung cancer[J].J Magn Reson Imaging,2019,49(4):1186-1194.
[21] SHI L,ZHANG Y,NIE K,et al.Machine learning for prediction of chemoradiation therapy response in rectal cancer using pre-treatment and mid-radiation multi-parametric MRI[J].Magn Reson Imaging,2019,61:33-40.
[22] 侯晓霞,贾亮,罗婷,等.经阴道彩色多普勒超声参数与子宫内膜癌患者病理特征及预后的关系[J].疑难病杂志,2022,21(8):784-788.
[23] 王立淑,于腾飞,徐云,等.超声造影在子宫内膜恶性病变诊断中的价值[J].中华超声影像学杂志,2022,31(3):226-230.
[24] 陈寸,吉文倩,刘伟,等.经阴道超声测量子宫内膜厚度对老年患者子宫内膜癌的诊断作用[J].中国老年学杂志,2020,40(19):4106-4108.
[25] 赵映琴,徐嘉,黄弋庭,等.经阴道三维超声和MRI在子宫内膜癌患者术前评估中的一致性分析[J].影像科学与光化学,2020,38(6):1018-1022.
[26] 车月玫,骆文香,董晓红,等.经阴道彩色多普勒超声联合CT对子宫内膜癌的诊断效能[J].影像科学与光化学,2020,38(5):910-913.

相似文献/References:

[1]冯苗苗,曹秋雨.miR335在子宫内膜癌患者血清中的表达及检测临床意义[J].陕西医学杂志,2019,(2):252.
　FENG Miaomiao,CAO Qiuyu..The expression and significance of miR335 in serum of patients with endometrial carcinoma[J].,2019,(8):252.
[2]刘家利,谢小军.子宫内膜癌组织HIF-1α、血清CA125水平在患者病情与疾病预后评估中的价值[J].陕西医学杂志,2019,(6):800.
[3]张晓勇.宫腔镜辅助下分段诊刮术与单纯分段诊刮术诊断子宫内膜癌价值比较[J].陕西医学杂志,2019,(8):1045.
　ZHANG Xiaoyong..Comparison of hysteroscopy assisted dilatation and curettage and traditional dilatation  and curettage in the diagnosis of endometrial carcinoma[J].,2019,(8):1045.
[4]吴 明,张欣玉△,石 锋,等.超声造影联合CT检查对甲状腺良恶性结节的鉴别诊断研究[J].陕西医学杂志,2020,49(3):333.
　WU Ming,ZHANG Xinyu,SHI Feng,et al.Differential diagnosis of benign and malignant thyroid nodules by contrast-enhanced ultrasound combined with CT[J].,2020,49(8):333.
[5]王双龙,吕 镔△,李 龙,等.超声造影参数成像在甲状腺微小乳头状癌鉴别诊断中的应用价值*[J].陕西医学杂志,2020,49(5):599.
　WANG Shuanglong,LV Bin,LI Long,et al.The value of parametric imaging of contrast-enhanced ultrasound in differential diagnosis of papillary thyroidmicrocarcinoma[J].,2020,49(8):599.
[6]周 璇,刘海静,白 洁△.经腹超声造影鉴别诊断子宫内膜病变价值及与微血管密度关系探讨*[J].陕西医学杂志,2020,49(8):960.[doi:DOI:10.3969/j.issn.1000-7377.2020.08.012]
　ZHOU Xuan,LIU Haijing,BAI Jie..Value of transabdominal contrast-enhanced ultrasonography in the differential diagnosis of endometrial lesions and its relationship with microvessel density[J].,2020,49(8):960.[doi:DOI:10.3969/j.issn.1000-7377.2020.08.012]
[7]李春艳,李忠原△.基于超声组学的甲状腺结节良恶性预测关键技术研究[J].陕西医学杂志,2020,49(9):1134.[doi:DOI:10.3969/j.issn.1000-7377.2020.09.020]
　LI Chunyan,LI Zhongyuan..Study on the key technique of benign and malignant thyroid nodule prediction based on ultrasomics[J].,2020,49(8):1134.[doi:DOI:10.3969/j.issn.1000-7377.2020.09.020]
[8]芦 霄,秦海英,张 悦,等.超声引导下微创消融治疗子宫腺肌症疗效评估[J].陕西医学杂志,2021,50(1):32.[doi:DOI:10.3969/j.issn.1000-7377.2021.01.008]
　LU Xiao,QIN Haiying,ZHANG Yue,et al.Evaluation of ultrasound-guided minimally invasive ablation of adenomyosis[J].,2021,50(8):32.[doi:DOI:10.3969/j.issn.1000-7377.2021.01.008]
[9]徐 珊,程 珂,刘鹏宇.子宫内膜癌组织血管紧张素(1-7)、miR-106b表达与患者临床病理分期相关性研究[J].陕西医学杂志,2022,51(5):621.[doi:DOI:10.3969/j.issn.1000-7377.2022.05.025]
　XU Shan,Cheng Ke,LIU Pengyu.Correlation between the expression of angiotensin(1-7),miR-106b in endometrial cancer tissue and clinicopathological stage of patients[J].,2022,51(8):621.[doi:DOI:10.3969/j.issn.1000-7377.2022.05.025]
[10]都 燕,代 佳.血清细胞角蛋白19片段、α-烯醇化酶检测在子宫内膜癌诊断及病情严重程度评估中的价值[J].陕西医学杂志,2023,52(2):212.[doi:DOI:10.3969/j.issn.1000-7377.2023.02.022]
　DU Yan,DAI Jia.Value of serum cytokeratin 19 fragment and α-enolase detection in diagnosis and severity assessment of endometrial carcinoma[J].,2023,52(8):212.[doi:DOI:10.3969/j.issn.1000-7377.2023.02.022]

备注/Memo

备注/Memo:
基金项目:四川省医学科研课题(S18063)
更新日期/Last Update: 2024-08-08