[1]黄丹丹,陈志祥,吴文龙,等.外周血红细胞分布宽度、平均血小板容积、中性粒细胞与淋巴细胞比值、血小板与淋巴细胞比值和淋巴细胞与单核细胞比值对肺癌的诊断价值研究[J].陕西医学杂志,2024,(8):1047-1050.[doi:DOI:10.3969/j.issn.1000-7377.2024.08.008]
　HUANG Dandan,CHEN Zhixiang,WU Wenlong,et al.Diagnostic value of peripheral blood RDW,MPV,NLR,PLR and LMR in lung cancer[J].,2024,(8):1047-1050.[doi:DOI:10.3969/j.issn.1000-7377.2024.08.008]
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外周血红细胞分布宽度、平均血小板容积、中性粒细胞与淋巴细胞比值、血小板与淋巴细胞比值和淋巴细胞与单核细胞比值对肺癌的诊断价值研究
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
期数:
2024年8期
页码:
1047-1050
栏目:
临床研究
出版日期:
2024-08-05

文章信息/Info

Title:
Diagnostic value of peripheral blood RDW,MPV,NLR,PLR and LMR in lung cancer
作者:
黄丹丹; 陈志祥; 吴文龙; 许 静; 安 钱
(安徽中医药高等专科学校附属芜湖市中医医院呼吸与危重症医学科,安徽 芜湖 241000)
Author(s):
HUANG Dandan; CHEN Zhixiang; WU Wenlong; XU Jing; AN Qian
(Department of Respiratory and Critical Care Medicine,Wuhu Hospital of Traditional Chinese Medicine,Anhui College of Traditional Chinese Medicine,Wuhu 241000,China)
关键词:
肺癌;  红细胞分布宽度;  平均血小板容积;  中性粒细胞与淋巴细胞比值;  血小板与淋巴细胞比值;  淋巴细胞与单核细胞比值
Keywords:
Lung cancer;  Red blood cell distribution width;  Mean platelet volume;  Neutrophil-to-lymphocyte ratio;  Platelet-to-lymphocyte ratio;  Lymphocyte-to-monocyte ratio
分类号:
R 734.2
DOI:
DOI:10.3969/j.issn.1000-7377.2024.08.008
文献标志码:
A
摘要:
目的:探讨外周血红细胞分布宽度(RDW)、平均血小板容积(MPV)、中性粒细胞与淋巴细胞比值(NLR)、血小板与淋巴细胞比值(PLR)及淋巴细胞与单核细胞比值(LMR)在肺癌中的诊断价值。方法:选取113例肺癌患者(肺癌组)和113例体检健康者(对照组)。检测两组全血细胞并计算NLR、PLR、MPV。绘制受试者工作特征(ROC)曲线分析RDW、MPV、NLR、LMR和PLR对肺癌的诊断价值。结果:肺癌组患者RDW、NLR、PLR和MPV值高于对照组,LMR低于对照组(均P<0.05)。RDW、MPV、NLR、PLR和LMR在肺癌组不同病理学亚组间比较差异无统计学意义(均P>0.05)。RDW、MPV、NLR、PLR、LMR的曲线下面积(AUC)分别为0.600、0.629、0.882、0.788、0.868,而五项联合诊断肺癌的AUC(0.933)更高(均P<0.05)。结论:肺癌患者外周血RDW、NLR、PLR和MPV升高,LMR降低,五项联合对肺癌的诊断价值较高。
Abstract:
Objective:To investigate the diagnostic value of peripheral blood RDW,MPV,NLR,PLR and LMR in lung cancer.Methods:A total of 113 patients with lung cancer(lung cancer group)and 113 healthy subjects(control group)were selected.The whole blood cells of the two groups were detected and NLR,PLR and MPV were calculated.Receiver operating characteristic(ROC)curves were drawn to analyze the diagnostic value of RDW,MPV,NLR,LMR and PLR in lung cancer.Results:RDW,NLR,PLR and MPV in lung cancer group were higher than those in control group,and LMR was lower than that in control group(all P<0.05).There was no significant difference in RDW,MPV,NLR,PLR and LMR among different pathological subgroups of lung cancer group(all P>0.05).The area under the curve(AUC)of RDW,MPV,NLR,PLR and LMR were 0.600,0.629,0.882,0.788 and 0.868,respectively,while the AUC of the combined diagnosis of lung cancer was higher(all P<0.05).Conclusion: Peripheral blood RDW,NLR,PLR and MPV are increased in patients with lung cancer,while LMR is decreased,and the combination of the five has high diagnostic value for lung cancer.

参考文献/References:

[1] 刘丽,武愫斌.双氧化酶成熟因子2基因检测在肺癌患者淋巴结转移及预后预测中的价值研究[J].陕西医学杂志,2022,51(8):1029-1032.
[2] MANTOVANI A,ALLAVENA P,SICA A,et al.Cancer related inflammation[J].Nature,2008,454:436-444.
[3] 张栓宝,严宁娟,张燕平.复方斑蝥胶囊对非小细胞肺癌患者围术期血清炎症因子及免疫功能的影响[J].陕西中医,2019,40(7):890-892.
[4] BALKWILL F,MANTOVANI A.Inflammation and cancer:Back to Virchow?[J].Lancet,2001,357:539-545.
[5] KALEMKERIAN G P,LOO B W,AKERLEY W,et al.NCCN guidelines insights:Small cell lung cancer,version 2.2018[J].J Natl Compr Canc Netw,2018,16(10):1171-1182.
[6] YUAN Y,ZHONG H,YE L,et al.Prognostic value of pretreatment platelet counts in lung cancer:A systematic review and meta-analysis[J].BMC Pulmonary Medicine,2020,20(1):1-11.
[7] ELLINGSEN T S,LAPPEGARD J,SKJELBAKKEN T,et al.Impact of red cell distribution width on future risk of cancer and allcause mortality among cancer patients-the Tromsø Study[J].Haematologica,2015,100(10):e387-e389.
[8] XU W Y,YANG X B,WANG W Q,et al.Prognostic impact of the red cell distribution width in esophageal cancer patients:A systematic review and meta-analysis[J].World J Gastroenterol,2018,24(19):2120-2129.
[9] YAZICI P,DEMIR U,BOZKURT E,et al.The role of red cell distribution width in the prognosis of patients with gastric cancer[J].Cancer Biomarkers,2017,18(1):19-25.
[10] KOMA Y,ONISHI A,MATSUOKA H,et al.Increased red blood cell distribution width associates with cancer stage and prognosis in patients with lung cancer[J].PLoS One,2013,8(11):e80240.
[11] LIPPI G,PLEBANI M.Red blood cell distribution width(RDW)and human pathology.One size fits all[J].Clin Chem Lab Med,2014,52(9):1247-1249.
[12] ARGILES J M.Cancer-associated malnutrition[J].Eur J Oncol Nurs,2005,9(2):s39-s50.
[13] MONTAGNANA M,DANESE E.Red cell distribution width and cancer[J].Ann Transl Med,2016,4(20):399.
[14] 刘海涛,衣秀秀,田建辉.肺癌中西医抗凝治疗研究进展[J].陕西中医,2020,41(1):127-130.
[15] LEE Y,KIM S H,HAN J Y,et al.Early neutrophil-to lymphocyte ratio reduction as a surrogate marker of prognosis in never smokers with advanced lung adenocarcinoma receiving gefitinib or standard chemotherapy as first-line therapy[J].J Cancer Res Clin Oncol,2012,138:2009-2016.
[16] PETRIE H T,KLASSEN L W,KAY H D.Inhibition of human cytotoxic T lymphocyte activity in vitro by autologous peripheral blood granulocytes[J].J Immunol,1985,134:230-234.
[17] OHASHI R,TAKAHASHI K,MIURA K,et al.Prognostic factors in patients with inoperable non-small cell lung cancer-an analysis of long-term survival patients[J].Gan To Kagaku Ryoho,2006,33(11):1595-1602.
[18] CONDEELIS J,POLLARD J W.Macrophages:Obligate partners for tumor cell migration,invasion,and metastasis[J].Cell,2006,124(2):263-266.
[19] 周晓云,王琛,顾若琪,等.白蛋白、D-二聚体、中性粒细胞、血小板淋巴细胞比值及血小板计数对社区获得性肺炎严重程度的诊断价值[J].陕西医学杂志,2024,53(1):104-108.
[20] GOUBRAN H A,BURNOUF T,RADOSEVIC M,et al.The platelet-cancer loop[J].Eur J Intern Med,2013,24:393-400.
[21] 李君艳,陈国荣.肺癌患者凝血指标与临床特征的关系[J].陕西医学杂志,2019,48(6):718-721.
[22] 任东峰,孙国芳.六君祛痰解毒汤联合化疗治疗非小细胞肺癌疗效及对患者血管内皮生长因子的影响[J].陕西中医,2020,41(1):63-65.
[23] BENOY I,SALGADO R,COLPAERT C,et al.Serum interleukin 6,plasma VEGF,serum VEGF,and VEGF platelet load in breast cancer patients[J].Clin Breast Cancer,2002,2(4):311-315.
[24] WIESNER T,BUGL S,MAYER F,et al.Differential changes in platelet VEGF,Tsp,CXCL12,and CXCL4 in patients with metastatic cancer[J].Clin Exp Metastasis,2010,27(3):141-149.
[25] BAMBACE N M,HOLMES C E.The platelet contribution to cancer progression[J].Thromb Haemost,2011,9(2):237-249.
[26] 雷鸣,杨丽,胡太华,等.非小细胞肺癌远处转移与血小板参数变化的相关性分析[J].国际检验医学杂志,2015,36(6):729-730.
[27] MANGALPALLY K K,SIQUEIROS-GARCIA A,VADUGANATHAN M.Platelet activation patterns in plateletsize sub-populations:Differential responses to aspirin in vitro[J].J Thromb Thrombolysis,2010,30(3):251-262.
[28] 刘玲佩.肺癌患者血小板的检测及相关性研究[J].亚太传统医药,2011,7(7):92-93.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金区域创新联合基金资助项目(U20A20398); 安徽省芜湖市科技项目(2022CG36)
更新日期/Last Update: 2024-08-08