[1]王莉云,王会丽,盛国芳,等.奥西替尼二线治疗EGFR T790M突变非小细胞肺癌脑转移临床研究[J].陕西医学杂志,2024,(7):962-965.[doi:DOI:10.3969/j.issn.1000-7377.2024.07.021]
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奥西替尼二线治疗EGFR T790M突变非小细胞肺癌脑转移临床研究
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
期数:
2024年7期
页码:
962-965
栏目:
药物与临床
出版日期:
2024-07-05

文章信息/Info

作者:
王莉云王会丽盛国芳孙艳平曹艳芳
(承德市中心医院心胸介入血管外科,河北 承德 067000)
关键词:
奥西替尼 EGFR T790M突变 非小细胞肺癌 脑转移 二线治疗 不良反应
分类号:
R 734.2
DOI:
DOI:10.3969/j.issn.1000-7377.2024.07.021
文献标志码:
A
摘要:
目的:研究奥西替尼二线治疗EGFR T790M突变非小细胞肺癌(NSCLC)脑转移的临床疗效。方法:前瞻性选择一线治疗失败的EGFR T790M突变非小细胞肺癌脑转移患者100例。采用随机数字表法分为两组,各50例,观察组采用奥西替尼方案治疗,对照组采用培美曲塞+顺铂方案治疗。比较两组的治疗效果﹑脑转移肿瘤直径变化﹑血清肿瘤标志物及血管内皮生长因子(VEGF)水平及不良反应。结果:与对照组比较,观察组客观缓解率(68.0%与30.0%)及疾病控制率(88.0%与70.0%)明显较高(均P<0.05); 治疗后与对照组比较,观察组患者脑部肿瘤直径明显缩小,血清癌胚抗原(CEA)、神经特异性烯醇化酶(NSE)、VEGF水平明显降低,无进展生存期明显延长(均P<0.05); 两组腹泻、皮疹、骨髓抑制、恶心呕吐等不良反应发生率比较差异有统计学意义(均P<0.05)。结论:奥西替尼二线治疗EGFR T790M突变NSCLC脑转移可有效控制肿瘤进展,安全可行。

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备注/Memo

备注/Memo:
基金项目:河北省医学科学研究重点课题(20211664)
更新日期/Last Update: 2024-07-04