[1]朱雪莲,乔 飞,穆耶赛尔·马合木提,等.帕金森病患者血铜蓝白水平与黑质铁沉积相关性分析[J].陕西医学杂志,2024,(7):940-943.[doi:DOI:10.3969/j.issn.1000-7377.2024.07.016]
　ZHU Xuelian,QIAO Fei,MUYESAIR Mahemuti,et al.Correlation analysis between ceruloplasmin level and iron deposition in substantia nigra in patients with Parkinson's disease[J].,2024,(7):940-943.[doi:DOI:10.3969/j.issn.1000-7377.2024.07.016]
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帕金森病患者血铜蓝白水平与黑质铁沉积相关性分析
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
期数:
2024年7期
页码:
940-943
栏目:
临床研究
出版日期:
2024-07-05

文章信息/Info

Title:
Correlation analysis between ceruloplasmin level and iron deposition in substantia nigra in patients with Parkinson's disease
作者:
朱雪莲1; 乔 飞1 ; 穆耶赛尔·马合木提1; 孙锦平2; 张 煜3
(1.新疆生产建设兵团第四师医院神经内科,新疆 伊宁 835000; 2.青岛大学附属医院平度院区急诊门诊,山东 青岛 266700; 3.上海交通大学医学院附属新华医院神经内科,上海200092)
Author(s):
ZHU Xuelian; QIAO Fei; MUYESAIR Mahemuti; SUN Jinping; ZHANG Yu
(Department of Neurology,Fourth Division Hospital of Xinjiang Production and Construction Corps,Yining 835000,China)
关键词:
帕金森病;  低铜蓝蛋白血症;  黑质;  铁沉积;  相关性;  经磁敏感加权成像
Keywords:
Parkinson's disease;  Hypoceruloplasminemia;  Substantia nigra;  Iron deposition;  Correlation;  Susceptibility-weighted imaging
分类号:
R 741
DOI:
DOI:10.3969/j.issn.1000-7377.2024.07.016
文献标志码:
A
摘要:
目的:探讨帕金森病(PD)患者血铜蓝蛋白水平与黑质铁沉积的相关性。方法:回顾性分析收治的107例PD患者临床资料,所有患者均检测血浆铜蓝蛋白(Cp)水平,据其水平分成对照组(Cp≥0.25 g/L)52例与观察组(Cp<0.25 g/L)45例。运用PD统一评分量表第三部分(UPDRS-Ⅲ)、Hoehn Yahr(H-Y)分级评估患者疾病状况,所有患者均接受经磁敏感加权成像检查,观察两组不同脑区相位值变化,并分析Cp水平与H-Y分级及Cp水平与UPDRS-Ⅲ评分、相位值的相关性。结果:观察组SN相位值低于对照组,UPDRS-Ⅲ评分及Cp低于对照组,差异有统计学意义(均P<0.05); 中晚期H-Y分级患者UPDRS-Ⅲ评分低于对照组,差异有统计学意义(P<0.05)。Spearmna相关性分析,SN相位值与Cp水平、UPDRS-Ⅲ评分均呈正相关(均P<0.05),而Cp、SN相位值与H-Y分级不具有相关性(均P>0.05)。结论:PD患者Cp水平与黑质铁沉积密切相关,PD患者血浆Cp越低,黑质铁沉积越严重。
Abstract:
Objective:To investigate the correlation between ceruloplasmin(Cp)level and iron deposition in the substantia nigra in patients with Parkinson's disease(PD).Methods:The clinical data of 107 patients with PD were analyzed retrospectively.According to Cp level,the patients were divided into control group(Cp level ≥0.25 g/L,52 cases)and observation group(Cp level <0.25 g/L,45 cases).The patients' condition was evaluated using the Unified Parkinson's Disease Rating Scale-part Ⅲ(UPDRS-Ⅲ)and Hoehn-Yahr(H-Y)grading.All patients received susceptibility-weighted imaging examination and the changes in phase values of different brain regions in the two groups were analyzed.The correlation between Cp level and H-Y grading,as well as the correlation between Cp level and UPDRS-Ⅲ score and phase value were analyzed.Results:The SN phase value of the observation group was lower than that of the control group,and the UPDRS-Ⅲ score and Cp were lower than those of the control group(all P<0.05).The UPDRS-Ⅲ score of patients with advanced H-Y grade was lower than that of the control group(P<0.05).Spearmna correlation analysis found that SN phase value was positively correlated with Cp level and UPDRS-Ⅲ scores(all P<0.05),Cp and SN phase value were not correlated with H-Y grading(all P>0.05).Conclusion:Cp level is closely related to iron deposition in the substantia nigra in patients with PD.The lower the Cp level,the more severe the iron deposition in substantia nigra.

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备注/Memo

备注/Memo:
基金项目:兵团财政科技计划项目(S2022CD198)
更新日期/Last Update: 2024-07-04