[1]刘岩松,祁 烁,张 洁,等.660 nm激光照射对肥胖小鼠代谢的影响实验研究[J].陕西医学杂志,2024,(6):759-763.[doi:DOI:10.3969/j.issn.1000-7377.2024.06.008]
　LIU Yansong,QI Shuo,ZHANG Jie,et al.Effects of 660 nm laser irradiation on metabolism in obese mice[J].,2024,(6):759-763.[doi:DOI:10.3969/j.issn.1000-7377.2024.06.008]
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660 nm激光照射对肥胖小鼠代谢的影响实验研究
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
期数:
2024年6期
页码:
759-763
栏目:
基础研究
出版日期:
2024-06-05

文章信息/Info

Title:
Effects of 660 nm laser irradiation on metabolism in obese mice
作者:
刘岩松1; 祁 烁1; 张 洁2; 石颖慧2; 王铁山2
(1.北京中医药大学孙思邈医院,陕西 铜川 727031; 2.北京中医药大学生命科学学院,北京 102488)
Author(s):
LIU Yansong; QI Shuo; ZHANG Jie; SHI Yinghui; WANG Tieshan
(Sun Simiao Hospital,Beijing University of Chinese Medicine,Tongchuan 727031,China)
关键词:
肥胖;  660 nm 激光;  高脂饮食;  代谢;  小鼠;  脂肪组织
Keywords:
Obesity;  660 nm laser;  High-fat diet;  Metabolism;  Mice;  Adipose tissue
分类号:
R 589.2
DOI:
DOI:10.3969/j.issn.1000-7377.2024.06.008
文献标志码:
A
摘要:
目的:探究660 nm激光照射对肥胖小鼠代谢水平的影响。方法:24只C57BL/6J小鼠随机分成对照组(8只)和高脂饮食组(16只)。高脂饮食组成功造成肥胖模型后,再次随机分为模型组和660 nm激光照射组(PBMT组),每组8只。PBMT组以每天照射1次的频率进行干预,在此期间对照组使用正常饲料喂养,模型组和PBMT组使用高脂肪饲料喂养。观察小鼠体重、耐寒能力、空腹血糖、谷丙转氨酶(ALT)、天冬氨酸氨基转移酶(AST)、尿素氮(BUN)、肌酐(CRE)、总胆固醇(CHO)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、甘油三酯(TG)等指标变化; 测量腹股沟白色脂肪组织(iWAT)和附睾白色脂肪组织(eWAT)重量。结果:与对照组比较,模型组体重上升,耐寒能力降低,空腹血糖、ALT、AST水平升高,iWAT、eWAT重量上升(均P<0.05)。与模型组比较,PBMT组体重下降,耐寒能力提升,空腹血糖、ALT、AST水平下降,BUN水平升高,iWAT、eWAT重量下降(均P<0.05)。结论:660 nm激光照射能够降低肥胖小鼠体重,提高葡萄糖、脂质代谢水平,保护肝功能,降低血糖并减少腹部脂肪堆积。
Abstract:
Objective:To investigate the effect of 660 nm laser irradiation on metabolism in obese mice.Methods:A total of 24 C57BL/6J mice were randomly divided into control group(n=8)and high-fat diet group(n=16).After the obesity model was successfully established in the high-fat diet group,the mice were randomly divided into model group and 660 nm laser irradiation(PBMT)group,with 8 mice in each group.The PBMT group(660 nm laser irradiation)received daily irradiation,while the control group consumed a normal diet,and both the model and PBMT groups were fed a high-fat diet.The changes of body weight,cold tolerance,fasting blood glucose,ALT,AST,BUN,CRE,CHO,HDL-C,LDL-C and TG were observed.The weight of inguinal white adipose tissue(iWAT)and epididymal white adipose tissue(eWAT)were measured.Results: Compared to the control group,the model group showed an increase in body weight,decreased cold resistance,elevated levels of fasting blood glucose,ALT,and AST.Additionally,there was an increase in the weights of iWAT and eWAT(all P<0.05).Compared to the model group,the PBMT group exhibited a decrease in body weight,improved cold tolerance,decreased levels of fasting blood glucose,ALT,and AST,and increased BUN levels.Additionally,there was a reduction in the weights of iWAT and eWAT(all P<0.05).Conclusion:The 660 nm laser irradiation can reduce body weight,improve glucose and lipid metabolism,protect liver function,reduce blood glucose and reduce abdominal fat accumulation in obese mice.

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备注/Memo

备注/Memo:
基金项目:陕西省中医药中青年科技骨干人才项目(2023-ZQNY-014)
更新日期/Last Update: 2024-06-05