[1]王赓丰,崔家康,孟庆良.铁死亡在系统性红斑狼疮中的作用研究进展[J].陕西医学杂志,2024,(5):710-713.[doi:DOI:10.3969/j.issn.1000-7377.2024.05.031]
 WANG Gengfeng,CUI Jiakang,MENG Qingliang.Research progress on the role of ferrosis in systemic lupus erythematosus[J].,2024,(5):710-713.[doi:DOI:10.3969/j.issn.1000-7377.2024.05.031]
点击复制

铁死亡在系统性红斑狼疮中的作用研究进展
分享到:

《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
期数:
2024年5期
页码:
710-713
栏目:
综 述
出版日期:
2024-05-05

文章信息/Info

Title:
Research progress on the role of ferrosis in systemic lupus erythematosus
作者:
王赓丰1崔家康2孟庆良2
(1.河南中医药大学骨伤学院,河南 郑州 450002; 2.河南中医药大学第二附属医院风湿免疫科,河南 郑州 450053)
Author(s):
WANG GengfengCUI JiakangMENG Qingliang
(School of Orthopedics and Traumatology,Henan University of Chinese Medicine,Zhengzhou 450002,China)
关键词:
系统性红斑狼疮 铁死亡 中性粒细胞 淋巴细胞 巨噬细胞 铁调素
Keywords:
Systemic lupus erythematosus Ferroptosis Neutrophils Lymphocytes Macrophages Hepcidin
分类号:
R 593.24
DOI:
DOI:10.3969/j.issn.1000-7377.2024.05.031
文献标志码:
A
摘要:
系统性红斑狼疮(SLE)是一种病因不明的弥漫性结缔组织病,伴有自身抗体产生和炎症反应。铁死亡是一种以铁的过度蓄积以及脂质的过度氧化为主要特点的细胞死亡方式,其核心主要包括氨基酸代谢异常、脂质代谢异常、铁代谢异常以及其他代谢异常。目前已发现与SLE发病密切相关的多种免疫细胞与铁死亡关系紧密,铁的稳态以及维持其平衡的铁调素与SLE之间也有很强的关联。现就铁死亡的相关机制及其与SLE之间的潜在联系进行综述,并为SLE的治疗策略提供新的思路。
Abstract:
Systemic lupus erythematosus(SLE)is a diffuse connective tissue disease of unknown etiology associated with autoantibody production and inflammation.Iron death is a kind of cell death mode characterized by excessive accumulation of iron and excessive oxidation of lipids.The core of iron death mainly includes abnormal amino acid metabolism,lipid metabolism,iron metabolism and other metabolic abnormalities.At present,it has been found that a variety of immune cells closely related to SLE are closely related to iron death,and iron homeostasis and hepcidin,which maintains its balance,are also strongly related to SLE.This article reviews the mechanism of iron death and the potential relationship between iron death and SLE,and provides new ideas for the treatment of SLE.

参考文献/References:

[1] DEMIRKAN F G,DOGAN S,KALYONCU R A,et al.Systemic lupus erythematosus complicated with castleman disease:A case-based review[J].Rheumatology International,2021,41(2):475-479.
[2] LI S,HUANG Y.Ferroptosis:An iron-dependent cell death form linking metabolism,diseases,immune cell and targeted therapy[J].Clinical & Translational Oncology,2022,24(1):1-12.
[3] DIXON S J,LEMBERG K M,LAMPRECHT M R,et al.Ferroptosis:An iron-dependent form of nonapoptotic cell death[J].Cell,2012,149(5):1060-1072.
[4] STOCKWELL B R,JIANG X,GU W.Emerging mechanisms and disease relevance of ferroptosis[J].Trends in Cell Biology,2020,30(6):478-490.
[5] LEI G,ZHUANG L,GAN B.Targeting ferroptosis as a vulnerability in cancer[J].Nature Reviews Cancer,2022,22(7):381-396.
[6] 赵志,林进权,王春雨,等.铁死亡、自噬及两者关联在胃癌发生中的研究进展[J].陕西医学杂志,2023,52(9):1268-1271.
[7] LI C,DENG X,XIE X,et al.Activation of glutathione peroxidase 4 as a novel anti-inflammatory strategy[J].Frontiers in Pharmacology,2018,9:1120.
[8] 张一楠,任彩佩,吴亚俐,等.白藜芦醇通过调节铁死亡通路抑制小鼠溃疡性结肠炎相关性结肠癌实验研究[J].陕西医学杂志,2023,52(6):671-675.
[9] LAI B,WU C H,WU C Y,et al.Ferroptosis and autoimmune diseases[J].Frontiers in Immunology,2022,13:916664.
[10] 李丽琴,张鼎,袁莉,等.温阳复元方联合miR-137模拟剂调控线粒体铁死亡对脑缺血再灌注损伤大鼠的作用机制[J].陕西中医,2023,44(10):1354-1359.
[11] 陈抒鹏,王思梦,唐娜娜,等.基于浊邪与铁死亡相关性探析动脉粥样硬化之病机[J].陕西中医,2022,43(11):1589-1591.
[12] YE Z,LIU W,ZHU O Q,et al.Ferroptosis:Final destination for cancer?[J].Cell Proliferation,2020,53(3):12761.
[13] LIANG C,ZHANG X,YANG M,et al.Recent progress in ferroptosis inducers for cancer therapy[J].Advanced Materials,2019,31(51):1904197.
[14] JIANG L,KON N,LI T,et al.Ferroptosis as a p53-mediated activity during tumour suppression[J].Nature,2015,520(7545):57-62.
[15] 武秀权,吕伟豪,费晓炜,等.Parkin通过抑制神经元内铁死亡信号减轻机械性神经元损伤[J].空军军医大学学报,2022,43(5):410-414.
[16] WU J,MINIKES A M,GAO M,et al.Intercellular interaction dictates cancer cell ferroptosis via NF2-YAP signaling[J].Nature,2019,572(7769):402-406.
[17] KAGAN V E,TYURINA Y Y,SUN W Y,et al.Redox phospholipidomics of enzymatically generated oxygenated phospholipids as specific signals of programmed cell death[J].Free Radical Biology & Medicine,2020,147:231-241.
[18] GASCHLER M M,ANDIA A A,LIU H,et al.FINO2 initiates ferroptosis through GPX4 inactivation and iron oxidation[J].Nature Chemical Biology,2018,14(5):507-515.
[19] GUO X,LIU F,DENG J,et al.Electron-accepting micelles deplete reduced nicotinamide adenine dinucleotide phosphate and impair two antioxidant cascades for ferroptosis-induced tumor eradication[J].ACS Nano,2020,14(11):14715-14730.
[20] STOCKWELL B R,FRIEDMANN J P,BAYIR H,et al.Ferroptosis:A regulated cell death nexus linking metabolism,redox biology,and disease[J].Cell,2017,171(2):273-285.
[21] DOLL S,PRONETH B,TYURINA Y Y,et al.ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition[J].Nature Chemical Biology,2017,13(1):91-98.
[22] D'HERDE K,KRYSKO D V.Ferroptosis:Oxidized PEs trigger death[J].Nature Chemical Biology,2017,13(1):4-5.
[23] BERSUKER K,HENDRICKS J M,LI Z,et al.The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis[J].Nature,2019,575(7784):688-692.
[24] PIRES I S,BERTHIAUME F,PALMER A F.Engineering therapeutics to detoxify hemoglobin,heme,and iron[J].Annual Review of Biomedical Engineering,2023,25:1-21.
[25] PISKIN E,CIANCIOSI D,GULEC S,et al.Iron absorption:Factors,limitations,and improvement methods[J].ACS Omega,2022,7(24):20441-20456.
[26] GULEC S,ANDERSON G J,COLLINS J F.Mechanistic and regulatory aspects of intestinal iron absorption[J].American Journal of Physiology,2014,307(4):397-409.
[27] ZHANG F,TAO Y,ZHANG Z,et al.Metalloreductase Steap3 coordinates the regulation of iron homeostasis and inflammatory responses[J].Haematologica,2012,97(12):1826-1835.
[28] DRAKESMITH H,NEMETH E,GANZ T.Ironing out ferroportin[J].Cell Metabolism,2015,22(5):777-787.
[29] 黎淼,何琪,曾嘉旭,等.骨科相关疾病发生发展中的铁超载[J].中国组织工程研究,2023,27(17):2723-2728.
[30] BILLESBOLLE C B,AZUMAYA C M,KRETSCH R C,et al.Structure of hepcidin-bound ferroportin reveals iron homeostatic mechanisms[J].Nature,2020,586(7831):807-811.
[31] RAMEY G,DESCHEMIN J C,DUREL B,et al.Hepcidin targets ferroportin for degradation in hepatocytes[J].Haematologica,2010,95(3):501-504.
[32] PATEL P,KARCH J.Regulation of cell death in the cardiovascular system[J].International Review of Cell and Molecular Biology,2020,353:153-209.
[33] IMAI H,MATSUOKA M,KUMAGAI T,et al.Lipid peroxidation-dependent cell death regulated by GPx4 and ferroptosis[J].Current Topics in Microbiology and Immunology,2017,403:143-170.
[34] MAHAJAN A,HERRMANN M,MUNOZ L E.Clearance deficiency and cell death pathways:A model for the pathogenesis of SLE[J].Frontiers in Immunology,2016,7:35.
[35] LIEW P X,KUBES P.The neutrophil's role during health and disease[J].Physiological Reviews,2019,99(2):1223-1248.
[36] ZHAO M,LI M Y,GAO X F,et al.Downregulation of BDH2 modulates iron homeostasis and promotes DNA demethylation in CD4+T cells of systemic lupus erythematosus[J].Clinical Immunology,2018,187:113-121.
[37] MATSUSHITA M,FREIGANG S,SCHNEIDER C,et al.T cell lipid peroxidation induces ferroptosis and prevents immunity to infection[J].The Journal of Experimental Medicine,2015,212(4):555-568.
[38] GAMMELLA E,CORRENTI M,CAIRO G,et al.Iron availability in tissue microenvironment:The key role of ferroportin[J].International Journal of Molecular Sciences,2021,22(6):472-477.

相似文献/References:

[1]李 赟.系统性红斑狼疮患者血清补体C5a和红细胞沉降率检测及临床意义[J].陕西医学杂志,2020,49(1):52.
 LI Yun..Expression of serum C5a and ESR in patients with systemic lupus erythematosus and its clinical significance[J].,2020,49(5):52.
[2]张彦平,贺军涛△,殷 鉴,等.尿液免疫球蛋白轻链检测对系统性红斑狼疮肾脏损伤的诊断价值*[J].陕西医学杂志,2020,49(9):1172.[doi:DOI:10.3969/j.issn.1000-7377.2020.09.030]
 ZHANG Yanping,HE Juntao,YIN Jian,et al.Diagnostic value of urine U-kap and U-lam detection in renalinjury of systemic lupus erythematosus[J].,2020,49(5):1172.[doi:DOI:10.3969/j.issn.1000-7377.2020.09.030]
[3]刘湘慧,斯 韬,梁 婷,等.铁死亡发生机制及其在肝细胞癌中的作用研究进展[J].陕西医学杂志,2023,52(3):354.[doi:DOI:10.3969/j.issn.1000-7377.2023.03.025]
 LIU Xianghui,SI Tao,LIANG Ting,et al.Mechanism of ferroptosis and its role in hepatocellular carcinoma[J].,2023,52(5):354.[doi:DOI:10.3969/j.issn.1000-7377.2023.03.025]
[4]赵 志,林进权,王春雨,等.铁死亡、自噬及两者关联在胃癌发生中的研究进展[J].陕西医学杂志,2023,52(9):1268.[doi:DOI:10.3969/j.issn.1000-7377.2023.09.036]
 ZHAO Zhi,LIN Jinquan,WANG Chunyu,et al.Research progress on ferroptosis,autophagy and their correlation in gastric cancer[J].,2023,52(5):1268.[doi:DOI:10.3969/j.issn.1000-7377.2023.09.036]
[5]付永涛,王莉平,郭金明,等.羟氯喹通过Toll样受体4/核因子-κB信号通路对系统性红斑狼疮小鼠肺损伤的影响[J].陕西医学杂志,2023,52(11):1483.[doi:DOI:10.3969/j.issn.1000-7377.2023.11.007]
 FU Yongtao,WANG Liping,GUO Jinming,et al.Effect of hydroxychloroquine on lung injury in mice with systemic lupus erythematosus via TLR4/NF-κB signaling pathway[J].,2023,52(5):1483.[doi:DOI:10.3969/j.issn.1000-7377.2023.11.007]
[6]李 玥,陈俊逾.姜黄醇对大鼠抑郁的改善作用及机制实验研究[J].陕西医学杂志,2024,(3):303.[doi:DOI:10.3969/j.issn.1000-7377.2024.03.003]
 LI Yue,CHEN Junyu.Improving effect and mechanism of curcumol on depressed rats[J].,2024,(5):303.[doi:DOI:10.3969/j.issn.1000-7377.2024.03.003]
[7]杨加宁,张立然.沉默信息调节因子1/叉头框蛋白O1信号通路调控铁死亡对多囊卵巢综合征大鼠卵巢颗粒细胞的影响实验研究[J].陕西医学杂志,2024,(8):1035.[doi:DOI:10.3969/j.issn.1000-7377.2024.08.006]
 YANG Jianing,ZHANG Liran.Effect of silent information regulator 1/forkhead box protein O1 signaling pathway on ovarian granulosa cells in rats with polycystic ovary syndrome by regulating ferroptosis[J].,2024,(5):1035.[doi:DOI:10.3969/j.issn.1000-7377.2024.08.006]
[8]李 丽,蒋芙蓉,赵丽英,等.血清肿瘤坏死因子受体相关因子3和卵泡抑素样蛋白1检测对系统性红斑狼疮患者吗替麦考酚酯治疗无效的预测价值[J].陕西医学杂志,2024,(9):1254.[doi:DOI:10.3969/j.issn.1000-7377.2024.09.022]
 LI Li,JIANG Furong,ZHAO Liying,et al.Predictive value of serum TRAF3 and FSTL1 levels in patients with systemic lupus erythematosus for failure to respond to mycophenolate mofetil treatment[J].,2024,(5):1254.[doi:DOI:10.3969/j.issn.1000-7377.2024.09.022]
[9]王玲玲,詹宇威,杨 舟.系统性红斑狼疮合并感染患者淋巴细胞亚群、PLR、NLR、MLR水平变化及检测意义[J].陕西医学杂志,2024,(11):1487.[doi:DOI:10.3969/j.issn.1000-7377.2024.11.010]
[10]曾胜澜,梁健芬,邢俊娥,等.铁死亡在药物性肝损伤中的作用机制及治疗研究进展[J].陕西医学杂志,2024,(12):1718.[doi:DOI:10.3969/j.issn.1000-7377.2024.12.027]
 ZENG Shenglan,LIANG Jianfen,XING Jun'e,et al.Research progress on mechanism and treatment of ferroptosis in drug-induced liver injury[J].,2024,(5):1718.[doi:DOI:10.3969/j.issn.1000-7377.2024.12.027]

备注/Memo

备注/Memo:
基金项目:国家自然科学基金资助项目(81874456)
更新日期/Last Update: 2024-05-06