[1]王忠瑜,季艳霞,赵艳争,等.环状RNA ciRS-7在结直肠癌中的表达变化及其与患者临床病理特征和预后关系研究[J].陕西医学杂志,2024,(3):412-415.[doi:DOI:10.3969/j.issn.1000-7377.2024.03.027]
　WANG Zhongyu,JI Yanxia,ZHAO Yanzheng,et al.Expression change of circular RNA ciRS-7 in colorectal cancer and its relationship with clinicopathological features and prognosis of patients[J].,2024,(3):412-415.[doi:DOI:10.3969/j.issn.1000-7377.2024.03.027]
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环状RNA ciRS-7在结直肠癌中的表达变化及其与患者临床病理特征和预后关系研究
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
期数:
2024年3期
页码:
412-415
栏目:
临床病理
出版日期:
2024-03-05

文章信息/Info

Title:
Expression change of circular RNA ciRS-7 in colorectal cancer and its relationship with clinicopathological features and prognosis of patients
作者:
王忠瑜; 季艳霞; 赵艳争; 张伟光; 杨慧敏
(邯郸市中心医院,河北 邯郸 056008)
Author(s):
WANG Zhongyu; JI Yanxia; ZHAO Yanzheng; ZHANG Weiguang; YANG Huimin
(Handan Central Hospital,Handan 056008,China)
关键词:
结直肠癌;  环状RNA ciRS-7;  临床病理特征;  总生存期;  危险因素;  预后
Keywords:
Colorectal cancer;  Circular RNA ciRS-7;  Clinicopathologic feature;  Overall survival;  Risk factor;  Prognosis
分类号:
R 735.3
DOI:
DOI:10.3969/j.issn.1000-7377.2024.03.027
文献标志码:
A
摘要:
目的:探讨环状RNA ciRS-7在结直肠癌(CRC)中的表达变化及其与患者临床病理特征和预后的关系。方法:纳入CRC患者120例,通过手术获取癌组织和癌旁组织。比较癌组织与癌旁组织ciRS-7表达水平。分析ciRS-7表达水平与患者不同临床病理特征的关系。绘制Kaplan-Meier曲线并采用Log-Rank检验分析ciRS-7高低表达水平与患者总生存期(OS)的关系。采用Cox回归分析CRC患者OS的影响因素。结果:癌组织中ciRS-7表达水平高于癌旁组织(P<0.05)。ciRS-7表达水平与肿瘤直径、T分期、N分期、TNM分期有关(均P<0.05)。ciRS-7表达水平与患者OS呈负相关(P<0.05)。ciRS-7高表达、病理低/中分化、T3和T4分期是患者OS的独立危险因素(均P<0.05)。结论:ciRS-7在CRC患者中高表达,与癌症进展和不良预后有关。ciRS-7高表达是患者OS的独立危险因素。
Abstract:
Objective:To explore the expression change of circular RNA ciRS-7 in colorectal cancer(CRC)and its relationship with clinicopathological features and prognosis of patients.Methods:A total of 120 CRC patients were prospectively enrolled,and cancer tissues and adjacent tissues were obtained by surgery.The expression level of ciRS-7 in cancer tissues and adjacent tissues was compared.The relationship between ciRS-7 expression level and different clinicopathological features of patients was analyzed.Kaplan-Meier curve was drawn and Log-Rank test was used to analyze the relationship between ciRS-7 expression level and overall survival(OS)of patients.Cox regression was used to analyze the influencing factors of OS in CRC patients.Results:The expression level of ciRS-7 in cancer tissues was higher than that in adjacent tissues(P<0.05).The expression level of ciRS-7 was correlated with tumor diameter,T stage,N stage and TNM stage(all P<0.05).The expression level of ciRS-7 was negatively correlated with OS of patients(P<0.05).High ciRS-7 expression,low/moderate pathological differentiation,T3 and T4 staging were independent risk factors for OS in patients.Conclusion:ciRS-7 is highly expressed in CRC patients and is associated with cancer progression and poor prognosis.High expression of ciRS-7 is an independent risk factor for OS in patients.

参考文献/References:

[1] JAIN S,MAQUE J,GALOOSIAN A,et al.Optimal strategies for colorectal cancer screening[J].Curr Treat Options Oncol,2022,23(4):474-493.
[2] 朱绍华,何创业,赵芯.圆柱瘤蛋白、白细胞介素-6、白细胞介素-8在结直肠癌及癌前病变中的表达差异及其与患者临床病理特征的关系[J].陕西医学杂志,2022,51(12):1602-1606.
[3] 郑佳露,郑金洲,顾贤.藤龙补中汤联合化疗治疗晚期结直肠癌疗效研究[J].陕西中医,2023,44(8):1042-1046.
[4] 中华医学会肿瘤学分会,国家卫生健康委员会医政司.中国结直肠癌诊疗规范(2023版)[J].协和医学杂志,2023,14(4):706-733.
[5] LIU H,ZENG Z,ZHANG H,et al.Morbidity,mortality,and pathologic outcomes of transanal versus laparoscopic total mesorectal excision for rectal cancer short-term outcomes from a multicenter randomized controlled trial[J].Ann Surg,2023,277(1):1-6.
[6] 孟祥彩,刘洋,武玉,等.黄芩素在伊立替康抑制结肠癌细胞增殖中的作用研究[J].陕西中医,2022,43(12):1682-1685.
[7] 胡旭昊,孟昆,狄茂军.结直肠癌患者手术前后淋巴细胞与单核细胞比值动态变化及其对预后的预测价值[J].陕西医学杂志,2023,52(6):719-722,727.
[8] 侯志娟,文普帅.转移性结直肠癌患者总生存期的相关新基因APOH、KNG1和FGG[J].中国医科大学学报,2023,52(2):126-131.
[9] ZHAO P,MA G,MA L.Circ-0000479 promotes proliferation,invasion,migration and inflammation and inhibits apoptosis of rheumatoid arthritis fibroblast-like synoviocytes via miR-766/FKBP5 axis[J].J Orthop Surg Res,2023,18(1):220-228.
[10] XU S,LUO C,CHEN D,et al.CircMMD reduction following tumor treating fields inhibits glioblastoma progression through FUBP1/FIR/DVL1 and miR-15b-5p/FZD6 signaling[J].J Exp Clin Cancer Res,2023,42(1):64-76.
[11] 依力哈木?买买提,钟锴,艾合散?卡马力,等.环状RNA circ-0020123靶向调控微小RNA-145影响胰腺癌细胞SW-1990增殖、侵袭与转移实验研究[J].陕西医学杂志,2023,52(9):1140-1144.
[12] HUANG H,WEI L,QIN T,et al.Circular RNA ciRS-7 triggers the migration and invasion of esophageal squamous cell carcinoma via miR-7/KLF4 and NF-κB signals[J].Cancer Biol Ther,2019,20(1):73-80.
[13] SU C,HAN Y,ZHANG H,et al.CiRS-7 targeting miR-7 modulates the progression of non-small cell lung cancer in a manner dependent on NF-κB signaling[J].J Cell Mol Med,2018,22(6):3097-3107.
[14] LI R C,KE S,MENG F K,et al.CiRS-7 promotes growth and metastasis of esophageal squamous cell carcinoma via regulation of miR-7/HOXB13[J].Cell Death Dis,2018,9(8):838.
[15] CHEN J,YANG J,FEI X,et al.CircRNA ciRS-7:A novel oncogene in multiple cancers[J].Int J Biol Sci,2021,17(1):379-389.
[16] WENG W,WEI Q,TODEN S,et al.Circular RNA ciRS-7 a promising prognostic biomarker and a potential therapeutic target in colorectal cancer[J].Clin Cancer Res,2017,23(14):3918-3928.
[17] 马卫国,高云,王伟,等.环状RNA ciRS-7、circ-0058514和circ-Foxo3在食管鳞癌患者癌组织与血清中的表达及意义[J].中国肿瘤,2021,30(5):393-400.
[18] 安欣,崔志利,魏娉,等.环状RNA ciRS-7和EGFR在子宫内膜癌组织中的表达水平[J].河北医学,2019,25(8):1321-1325.
[19] ZHAO K,YE F,GAO P,et al.Circular RNA ciRS-7 promotes laryngeal squamous cell carcinoma development by inducing TGM3 hypermethylation via miR-432-5p/DNMT3B axis[J].Pathol Res Pract,2022,240:154193.
[20] MAO W,WANG K,XU B,et al.CiRS-7 is a prognostic biomarker and potential gene therapy target for renal cell carcinoma[J].Mol Cancer,2021,20(1):142-151.
[21] ZHOU Y,MAO X,PENG R,et al.CircRNAs in hepatocellular carcinoma:Characteristic,functions and clinical significance[J].Int J Med Sci,2022,19(14):2033-2043.
[22] 孟令娇,丁平安,巨英超,等.环状RNA ciRS-7在三阴性乳腺癌中的表达及其对细胞侵袭和迁移的影响[J].肿瘤防治研究,2019,46(3):233-238.
[23] 孟令娇,丁平安,刘思桦,等.微RNA-1299在三阴性乳腺癌中的表达及其对乳腺癌细胞迁移和侵袭的影响[J].肿瘤,2018,38(11):1022-1030.
[24] ZHANG Z,WANG Y,ZHANG Y,et al.The function and mechanisms of action of circular RNAs in urologic cancer[J].Molecular Cancer,2023,22(1):61.
[25] MENG L,LIU S,DING P,et al.Circular RNA ciRS-7 inhibits autophagy of ESCC cells by functioning as miR-1299 sponge to target EGFR signaling[J].J Cell Biochem,2020,121(2):1039-1049.

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备注/Memo

备注/Memo:
基金项目:河北省科技计划项目(162777222); 河北省医学科学研究课题(20220523)
更新日期/Last Update: 2024-03-05