[1]刘丽莹,朱 影,毛国顺,等.过敏性紫癜患儿预后影响因素及其预测价值研究[J].陕西医学杂志,2024,(3):382-385.[doi:DOI:10.3969/j.issn.1000-7377.2024.03.020]
　LIU Liying,ZHU Ying,MAO Guoshun,et al.Prognostic influencing factors and their predictive value of children with Henoch-Schnlein purpura[J].,2024,(3):382-385.[doi:DOI:10.3969/j.issn.1000-7377.2024.03.020]
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过敏性紫癜患儿预后影响因素及其预测价值研究
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
期数:
2024年3期
页码:
382-385
栏目:
临床研究
出版日期:
2024-03-05

文章信息/Info

Title:
Prognostic influencing factors and their predictive value of children with Henoch-Schönlein purpura
作者:
刘丽莹1; 朱 影1; 毛国顺1; 胡国生1; 王艳娟2
(1.阜阳市人民医院儿科,安徽 阜阳 236000; 2.芜湖市第一人民医院儿科,安徽 芜湖 241000)
Author(s):
LIU Liying; ZHU Ying; MAO Guoshun; HU Guosheng; WANG Yanjuan
(Department of Pediatrics,Fuyang People's Hospital,Fuyang 236000,China)
关键词:
过敏性紫癜;  儿童;  影响因素;  预后;  预测价值
Keywords:
Henoch-Schö; nlein purpura;  Children;  Influencing factors;  Prognosis;  Predictive value
分类号:
R 725.5
DOI:
DOI:10.3969/j.issn.1000-7377.2024.03.020
文献标志码:
A
摘要:
目的:探讨过敏性紫癜(HSP)患儿预后的影响因素及其预测价值。方法:选取HSP患儿150例为研究对象。根据患儿治疗后有无复发分为预后不良组(47例)和预后良好组(103例)。比较两组患儿一般资料及生化指标(白细胞计数、血小板计数、血清总蛋白、乳酸脱氢酶、碱性磷酸酶、C-反应蛋白、免疫球蛋白A)。分析HSP患儿预后的影响因素及其对患儿预后不良的预测价值。结果:预后不良组皮疹反复发作、初次发病伴肾损害和呼吸道感染比例高于预后良好组(均P<0.05)。预后不良组血小板计数、C-反应蛋白及免疫球蛋白A水平高于预后良好组(均P<0.05)。皮疹反复发作、初次发病伴肾损害、呼吸道感染、血小板计数、C-反应蛋白及免疫球蛋白A为HSP患儿预后的独立影响因素(均P<0.05)。皮疹反复发作、呼吸道感染、血小板计数、C-反应蛋白及免疫球蛋白A对HSP患儿预后不良具有预测价值(均P<0.05)。结论:皮疹反复发作、初次发病伴肾损害、呼吸道感染、血小板计数、C-反应蛋白及免疫球蛋白A为HSP患儿预后的独立影响因素。除初次发病伴肾损害指标外,其余指标对HSP患儿预后不良具有一定预测价值。
Abstract:
Objective:To explore the prognostic influencing factors and their predictive value of children with Henoch-Schönlein purpura(HSP ).Methods:A total of 150 children with HSP were selected as the study objects.The children were divided into poor prognosis group(47 cases)and good prognosis group(103 cases)according to recurrence or not after treatment.General data and biochemical indicators(white blood cell count,platelet count,and serum total protein,lactate dehydrogenase,alkaline phosphatase,C-reactive protein,immunoglobulin A)were compared between the two groups.The prognostic influencing factors and their predictive value for poor prognosis of children with HSP were analyzed.Results:The proportion of recurrent rash,initial onset with kidney damage and respiratory tract infection in the poor prognosis group were higher than those in the good prognosis group(all P<0.05).The levels of platelet count,C-reactive protein and immunoglobulin A in the poor prognosis group were higher than those in the good prognosis group(all P<0.05).Recurrent rash,initial onset with kidney damage,respiratory tract infection,platelet count,C-reactive protein and immunoglobulin A were the independent prognostic factors of HSP children(all P<0.05).Recurrent rash,respiratory tract infection,platelet count,C-reactive protein and immunoglobulin A had predictive values for poor prognosis of HSP children(all P<0.05).Conclusion:Recurrent rash,initial onset with renal damage,respiratory tract infection,platelet count,C-reactive protein and immunoglobulin A are the independent prognostic factors of HSP children.In addition to the indicator of initial onset with kidney damage,the other indicators have certain predictive value for poor prognosis of HSP children.

参考文献/References:

[1] HINES A M,MURPHY N,MULLIN C,et al.Henoch-Schönlein purpura presenting post COVID-19 vaccination[J].Vaccine,2021,39(33):4571-4572.
[2] 李根,马翠.过敏性紫癜患儿外周血微小RNA-155、Toll样受体2、Toll样受体4、氧化应激指标表达水平与Th17/Treg平衡的关系[J].陕西医学杂志,2023,52(3):301-304.
[3] EL-HASBANI G,TAHER A T,JAWAD A S M,et al.Henoch-Schönlein purpura:Another COVID-19 complication[J].Pediatr Dermatol,2021,38(5):1359-1360.
[4] 沈克彦.紫仙丹对过敏性紫癜患儿β2微球蛋白、尿微量白蛋白的影响[J].陕西中医,2020,41(10):1382-1384.
[5] 陈治峰,王丽,杜娟,等.益气化斑方治疗过敏性紫癜疗效及对患儿Gd-IgA1、NF-κB水平的影响[J].陕西中医,2019,40(2):237-240.
[6] 王晓亮,赵光宇.过敏性紫癜患儿血清基质金属蛋白酶-13、白细胞介素-9和肿瘤坏死因子-α表达水平变化及意义[J].陕西医学杂志,2022,51(1):92-95.
[7] 尹东豪,郭亚丽,曹童童,等.动物蛋白饮食对过敏性紫癜患儿预后的影响分析[J].中国当代儿科杂志,2021,23(9):927-932.
[8] NIKOLAISHVILI M,PAZHAVA A,DI-LERNIA V.Viral infections may be associated with Henoch-Schönlein purpura[J].J Clin Med,2023,12(2):697.
[9] 张艳,宋晓彤,王云,等.过敏性紫癜患儿复发的影响因素及IgE、IgA水平对其预测价值[J].分子诊断与治疗杂志,2021,13(12):2034-2037.
[10] 胡亚美,江载芳.诸福棠实用儿科学[M].8版.北京:人民卫生出版社,2015:773-774.
[11] WANG K,SUN X,JING S,et al.Development and validation of nomogram prediction model for severe kidney disease in children with Henoch-Schönlein purpura:A prospective analysis of two independent cohorts-forecast severe kidney disease outcome in 2480 hospitalized Henoch-Schönlein purpura children[J].Front Immunol,2022,13:999491.
[12] XIE Y,DENG Q,GUO M,et al.Proanthocyanidins:A novel approach to Henoch-Schonlein purpura through balancing immunity and arresting oxidative stress via TLR4/MyD88/NF-κB signaling pathway(Review)[J].Exp Ther Med,2023,25(6):300.
[13] Oñate I,ORTIZ M,SUSO A,et al.IgA vasculitis with nephritis(Henoch-Schönlein purpura)after COVID-19:A case series and review of the literature[J].Nefrologia(Engl Ed),2022,42(4):481-489.
[14] AL-EED A.Henoch-Schönlein purpura in Saudi Arabia:Characteristics and rare vital organ involvement[J].Minerva Pediatr(Torino),2021,73(4):363-370.
[15] 朱小波,范海燕,刘金祥.山莨菪碱结合孟鲁司特治疗过敏性紫癜患儿的临床研究及复发的危险因素分析[J].实用医学杂志,2021,37(3):385-389.
[16] HAMMAD H,KRAUSZ J,BARCAN M,et al.Adult Henoch-Schönlein purpura:Comprehensive assessment of demographic,clinical,and histopathological features as predictors for systemic involvement[J].Dermatology,2023,239(4):609-615.
[17] CHIBA T,OKADA S,KONDO Y,et al.Henoch-Schonlein purpura after cardiac device removal for staphylococcus aureus infective endocarditis[J].Circ J,2022,86(4):722.
[18] 吴盈盈,叶欢欢,周海燕.小儿过敏性紫癜复发的危险因素分析和风险预测模型构建[J].中国妇幼保健,2022,37(22):4214-4218.
[19] 卢毅,李玉芬,逯晓妮,等.D-二聚体和血小板与淋巴细胞计数比值与儿童过敏性紫癜性肾炎发病的研究进展[J].中国当代医药,2022,29(16):44-48.
[20] 肖飞,杨威,周芳.血小板及白细胞计数水平对过敏性紫癜患儿肾损伤的预测价值[J].中国中西医结合肾病杂志,2023,24(2):161-163.
[21] 马晓铮,王莹莹,刘琳琳.血清超敏C反应蛋白及胱抑素C在小儿过敏性紫癜早期肾损伤检测中的应用价值[J].当代医学,2022,28(21):155-157.
[22] 江敏.血清C反应蛋白检测在小儿过敏性紫癜诊断中的应用价值[J].中国实用医药,2021,16(20):98-100.
[23] 江雅静,宋丹阳,李金玲.血液及炎症指标对过敏性紫癜患儿复发风险的预测价值[J].中国实验血液学杂志,2023,31(3):837-842.
[24] 余丽娟,汤玉霞,余竹春,等.IL-17、IgA、IgE在过敏性紫癜患儿中的表达及影响患儿复发的危险因素分析[J].现代预防医学,2023,50(1):86-90.
[25] 杨建伟.外周血免疫球蛋白及抗心磷脂抗体水平检测对紫癜性肾炎患儿预后评估的价值分析[J].国际医药卫生导报,2020,26(20):3100-3103.

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备注/Memo

备注/Memo:
基金项目:安徽省自然科学基金资助项目(2108085MH262)
更新日期/Last Update: 2024-03-05