[1]廖崇皓,徐岸楠,李世瑶,等.血清壳多糖酶3样蛋白1和几丁质酶1在脓毒症新生儿中的表达变化及其临床价值研究[J].陕西医学杂志,2024,(3):368-371,376.[doi:DOI:10.3969/j.issn.1000-7377.2024.03.017]
　LIAO Chonghao,XU Annan,LI Shiyao,et al.Expression changes of serum chitosinase 3-like protein 1 and chitinase 1 in neonatal sepsis and their clinical value[J].,2024,(3):368-371,376.[doi:DOI:10.3969/j.issn.1000-7377.2024.03.017]
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血清壳多糖酶3样蛋白1和几丁质酶1在脓毒症新生儿中的表达变化及其临床价值研究
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
期数:
2024年3期
页码:
368-371,376
栏目:
临床研究
出版日期:
2024-03-05

文章信息/Info

Title:
Expression changes of serum chitosinase 3-like protein 1 and chitinase 1 in neonatal sepsis and their clinical value
作者:
廖崇皓; 徐岸楠; 李世瑶; 肖宗丽
(重庆市开州区人民医院新生儿科,重庆 405400)
Author(s):
LIAO Chonghao; XU Annan; LI Shiyao; XIAO Zongli
(Department of Neonatology,the People's Hospital of Kaizhou District,Chongqing 405400,China)
关键词:
脓毒症;  新生儿;  壳多糖酶3样蛋白1;  几丁质酶1;  预后;  预测价值
Keywords:
Sepsis;  Newborn;  Chitosinase 3-like protein 1;  Chitinase 1;  Prognosis;  Predictive value
分类号:
R 722.1
DOI:
DOI:10.3969/j.issn.1000-7377.2024.03.017
文献标志码:
A
摘要:
目的:探讨血清壳多糖酶3样蛋白1(CHI3L1)和几丁质酶1(CHIT1)在脓毒症新生儿中的表达变化及临床价值。方法:选取新生儿脓毒症95例为脓毒症组,根据病情严重程度分为严重脓毒症组(65例)和脓毒症休克组(30例)。选取健康新生儿65例为对照组。检测血清CHI3L1和CHIT1水平以及白细胞计数、中性粒细胞计数、肿瘤坏死因子-α(TNF-α)、白细胞介素-4(IL-4)、降钙素原(PCT)、C-反应蛋白(CRP)。分析血清CHI3L1、CHIT1水平与白细胞和中性粒细胞计数、TNF-α、IL-4、PCT、CRP的相关性。绘制受试者工作特征(ROC)曲线分析血清CHI3L1、CHIT1水平对脓毒症患儿预后的预测价值。结果:脓毒症组血清CHI3L1、CHIT1水平高于对照组(均P<0.05)。脓毒症休克组患儿血清CHI3L1和CHIT1水平、中性粒细胞计数、TNF-α、IL-4、PCT、CRP高于严重脓毒症组(均P<0.05)。脓毒症患儿血清CHI3L1、CHIT1水平与中性粒细胞计数、TNF-α、IL-4、PCT及CRP呈正相关(均P<0.05)。95例脓毒症患儿中病死15例,存活80例,病死组血清CHI3L1、CHIT1水平高于存活组(均P<0.05)。血清CHI3L1、CHIT1水平对脓毒症患儿预后均有一定的预测价值,且两者联合预测价值更高(均P<0.05)。结论:脓毒症新生儿血清CHI3L1和CHIT1水平升高,与病情严重程度及不良预后有关,两者联合对脓毒症新生儿的预后具有较高的预测价值。
Abstract:
Objective:To investigate the expression changes of serum chitinase 3-like protein 1(CHI3L1)and chitinase 1(CHIT1)in neonatal sepsis and their clinical value.Methods:Ninety-five cases of neonatal sepsis were selected as sepsis group and divided into severe sepsis group(65 cases)and septic shock group(30 cases)according to the severity of the disease.A total of 65 healthy newborns were selected as control group.Serum CHI3L1 and CHIT1 levels,leukocyte count,neutrophil count,TNF-α,IL-4,PCT,and CRP were measured.The correlations of serum CHI3L1 and CHIT1 levels with leukocyte and neutrophil count,TNF-α,IL-4,PCT and CRP were analyzed.ROC curve was drawn to analyze the prognostic value of serum CHI3L1 and CHIT1 levels in children with sepsis.Results:The levels of CHI3L1 and CHIT1 in sepsis group were higher than those in control group(all P<0.05).Serum CHI3L1 and CHIT1 levels,neutrophil count,TNF-α,IL-4,PCT and CRP in sepsis shock group were higher than those in severe sepsis group(all P<0.05).Serum CHI3L1 and CHIT1 levels were positively correlated with neutrophil count,TNF-α,IL-4,PCT and CRP in children with sepsis(all P<0.05).Among the 95 children with sepsis,15 children died and 80 survived.Serum CHI3L1 and CHIT1 levels in the dead group were higher than those in the surviving group(all P<0.05).Serum CHI3L1 and CHIT1 levels had a certain predictive value for the prognosis of children with sepsis,and their combined predictive value was higher(all P<0.05).Conclusion:Serum levels of CHI3L1 and CHIT1 are increased in newborns with sepsis,and are related to the severity of the disease and poor prognosis.The combination of the two has a high predictive value for the prognosis of neonates with sepsis.

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备注/Memo

备注/Memo:
基金项目:重庆市自然科学基金资助面上项目(CSTC2019JCYJ-MXMX051208)
更新日期/Last Update: 2024-03-05